(Q34701875)

4 August 2017

title

Inefficient TLR4/MD-2 heterotetramerization by monophosphoryl lipid A (English)

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4 August 2017

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Carolyn R Casella

1

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4 August 2017

Thomas C Mitchell

series ordinal

2

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4 August 2017

language of work or name

English

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publication date

26 April 2013

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4 August 2017

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4 August 2017

volume

8

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4 August 2017

issue

4

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4 August 2017

page(s)

e62622

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Creative Commons Attribution 4.0 International

4 August 2017

copyright license

start time

26 April 2013

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Human TLR4 polymorphism D299G/T399I alters TLR4/MD-2 conformation and response to a weak ligand monophosphoryl lipid A.

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NMR studies of hexaacylated endotoxin bound to wild-type and F126A mutant MD-2 and MD-2·TLR4 ectodomain complexes

7 July 2018

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Selective TRIF-dependent signaling by a synthetic toll-like receptor 4 agonist.

7 July 2018

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Different dimerisation mode for TLR4 upon endosomal acidification?

7 July 2018

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CD14 controls the LPS-induced endocytosis of Toll-like receptor 4

7 July 2018

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Genome-wide expression profiling and mutagenesis studies reveal that lipopolysaccharide responsiveness appears to be absolutely dependent on TLR4 and MD-2 expression and is dependent upon intermolecular ionic interactions

7 July 2018

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Toll-like receptors and their crosstalk with other innate receptors in infection and immunity

7 July 2018

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Mechanism of impaired NLRP3 inflammasome priming by monophosphoryl lipid A.

7 July 2018

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MyD88-dependent SHIP1 regulates proinflammatory signaling pathways in dendritic cells after monophosphoryl lipid A stimulation of TLR4.

7 July 2018

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7 July 2018

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Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling

7 July 2018

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Lipopolysaccharide-binding protein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells

7 July 2018

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Selective activation of the p38 MAPK pathway by synthetic monophosphoryl lipid A.

7 July 2018

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Comparison of the immunogenicity and safety of Cervarix and Gardasil human papillomavirus (HPV) cervical cancer vaccines in healthy women aged 18-45 years

7 July 2018

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7 July 2018

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The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex

7 July 2018

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Putting endotoxin to work for us: monophosphoryl lipid A as a safe and effective vaccine adjuvant

7 July 2018

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Roles for LPS-dependent interaction and relocation of TLR4 and TRAM in TRIF-signaling

7 July 2018

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Novel roles in human MD-2 of phenylalanines 121 and 126 and tyrosine 131 in activation of Toll-like receptor 4 by endotoxin

7 July 2018

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7 July 2018

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Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran

7 July 2018

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The vaccine adjuvant monophosphoryl lipid A as a TRIF-biased agonist of TLR4.

7 July 2018

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Specific high affinity interactions of monomeric endotoxin.protein complexes with Toll-like receptor 4 ectodomain

7 July 2018

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Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3637451

Regulatory roles for MD-2 and TLR4 in ligand-induced receptor clustering

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3637451

Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3637451

Cutting edge: TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not toll/IL-1 receptor domain-containing adaptor-inducing IFN-beta (TRIF)-dependent pathway in TLR signaling

7 July 2018

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Taking a Toll on human disease: Toll-like receptor 4 agonists as vaccine adjuvants and monotherapeutic agents

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3637451

Lipid A antagonist, lipid IVa, is distinct from lipid A in interaction with Toll-like receptor 4 (TLR4)-MD-2 and ligand-induced TLR4 oligomerization

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3637451

TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3637451

Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3...

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3637451

Lipopolysaccharide interaction with cell surface Toll-like receptor 4-MD-2: higher affinity than that with MD-2 or CD14.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3637451

Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3637451

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3637451

IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3637451

The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3637451

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3637451

A prophylactic hepatitis B vaccine with a novel adjuvant system

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3637451

Cutting edge: repurification of lipopolysaccharide eliminates signaling through both human and murine toll-like receptor 2.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3637451

Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3637451

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3637451

An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3637451

Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3637451

MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3637451

Lipopolysaccharide and monophosphoryl lipid A differentially regulate interleukin-12, gamma interferon, and interleukin-10 mRNA production in murine macrophages.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3637451

Toll-like receptor 4, but not toll-like receptor 2, is a signaling receptor for Escherichia and Salmonella lipopolysaccharides.

7 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0062622

The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascades

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0062622

Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0062622

Analysis of a monophosphoryl lipid A immunostimulant preparation from Salmonella minnesota R595 by high-performance liquid chromatography.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0062622

Cutting edge: cell surface expression and lipopolysaccharide signaling via the toll-like receptor 4-MD-2 complex on mouse peritoneal macrophages

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3637451

Safety and immunogenicity of a hepatitis B vaccine formulated with a novel adjuvant system

26 October 2018

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12 December 2020

Unresponsiveness of MyD88-deficient mice to endotoxin

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12 December 2020

The low-toxicity versions of LPS, MPL adjuvant and RC529, are efficient adjuvants for CD4+ T cells

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12 December 2020

Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes

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12 December 2020

Monophosphoryl lipid A activates both human dendritic cells and T cells

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0062622

Identifiers

DOI

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4 August 2017

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4 August 2017

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