(Q34718197)

English

Simvastatin represses protein synthesis in the muscle-derived C₂C₁₂ cell line with a concomitant reduction in eukaryotic initiation factor 2B expression

scientific article

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scholarly article

1 reference

Europe PubMed Central

4 August 2017

Simvastatin represses protein synthesis in the muscle-derived C₂C₁₂ cell line with a concomitant reduction in eukaryotic initiation factor 2B expression (English)

1 reference

Europe PubMed Central

4 August 2017

1 reference

based on heuristic

inferred from title

author name string

Alexander P Tuckow

1

1 reference

Europe PubMed Central

4 August 2017

Sarah J Jefferson

2

1 reference

Europe PubMed Central

4 August 2017

Scot R Kimball

3

1 reference

Europe PubMed Central

4 August 2017

Leonard S Jefferson

4

1 reference

Europe PubMed Central

4 August 2017

publication date

11 January 2011

1 reference

Europe PubMed Central

4 August 2017

American Journal of Physiology - Endocrinology and Metabolism

1 reference

Europe PubMed Central

4 August 2017

300

1 reference

Europe PubMed Central

4 August 2017

E564-70

1 reference

Europe PubMed Central

4 August 2017

3

1 reference

Europe PubMed Central

4 August 2017

Ectopic expression of eIF2Bepsilon in rat skeletal muscle rescues the sepsis-induced reduction in guanine nucleotide exchange activity and protein synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064004

7 July 2018

Lovastatin induces VSMC differentiation through inhibition of Rheb and mTOR.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064004

7 July 2018

Meta-analysis of comparative efficacy of increasing dose of Atorvastatin versus Rosuvastatin versus Simvastatin on lowering levels of atherogenic lipids (from VOYAGER).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064004

7 July 2018

Does simvastatin cause more myotoxicity compared with other statins?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064004

7 July 2018

Rosuvastatin inhibits norepinephrine-induced cardiac hypertrophy via suppression of Gh.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064004

7 July 2018

Immunomodulatory and anti-inflammatory activities of statins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064004

7 July 2018

Statin-induced muscle damage and atrogin-1 induction is the result of a geranylgeranylation defect

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064004

7 July 2018

Managing statin myopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064004

7 July 2018

Reduced eukaryotic initiation factor 2Bepsilon-subunit expression suppresses the transformed phenotype of cells overexpressing the protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064004

7 July 2018

Activation of the mammalian target of rapamycin complex 1 is both necessary and sufficient to stimulate eukaryotic initiation factor 2Bvarepsilon mRNA translation and protein synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064004

7 July 2018

Statin induced myotoxicity: the lactone forms are more potent than the acid forms in human skeletal muscle cells in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064004

7 July 2018

Phosphorylation of eIF2alpha in response to 26S proteasome inhibition is mediated by the haem-regulated inhibitor (HRI) kinase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064004

7 July 2018

A novel mechanism for the control of translation initiation by amino acids, mediated by phosphorylation of eukaryotic initiation factor 2B.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064004

7 July 2018

The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064004

7 July 2018

Pleiotropic effects of statins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064004

7 July 2018

The proteasome inhibitor, MG132, promotes the reprogramming of translation in C2C12 myoblasts and facilitates the association of hsp25 with the eIF4F complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064004

7 July 2018

Mutations causing childhood ataxia with central nervous system hypomyelination reduce eukaryotic initiation factor 2B complex formation and activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064004

7 July 2018

Defective translational control facilitates vesicular stomatitis virus oncolysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064004

7 July 2018

Statin-associated myopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064004

7 July 2018

Characterization of the initiation factor eIF2B and its regulation in Drosophila melanogaster

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064004

7 July 2018

Glycogen synthase kinase-3 is the predominant insulin-regulated eukaryotic initiation factor 2B kinase in skeletal muscle.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064004

7 July 2018

Regulation of eukaryotic initiation factor eIF2B: glycogen synthase kinase-3 phosphorylates a conserved serine which undergoes dephosphorylation in response to insulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064004

7 July 2018

A novel interaction between adrenergic receptors and the alpha-subunit of eukaryotic initiation factor 2B

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064004

7 July 2018

The catalytic mechanism of guanine nucleotide exchange factor action and competitive inhibition by phosphorylated eukaryotic initiation factor 2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064004

7 July 2018

Hydrophobic statins induce autophagy in cultured human rhabdomyosarcoma cells

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00383.2010

21 January 2018

Selective inhibition of growth of tuberous sclerosis complex 2 null cells by atorvastatin is associated with impaired Rheb and Rho GTPase function and reduced mTOR/S6 kinase activity

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00383.2010

21 January 2018

History of the cholesterol hypothesis in Britain

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00383.2010

21 January 2018

Phosphorylation of eukaryotic translation initiation factor 2Bepsilon by glycogen synthase kinase-3beta regulates beta-adrenergic cardiac myocyte hypertrophy.

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00383.2010

21 January 2018

Age-related deficit in load-induced skeletal muscle growth

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00383.2010

21 January 2018

Atorvastatin slows the progression of cardiac remodeling in mice with pressure overload and inhibits epidermal growth factor receptor activation

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00383.2010

21 January 2018

Blunted Akt/FOXO signalling and activation of genes controlling atrophy and fuel use in statin myopathy

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00383.2010

21 January 2018

HMG-CoA reductase inhibitor fluvastatin prevents angiotensin II-induced cardiac hypertrophy via Rho kinase and inhibition of cyclin D1.

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00383.2010

21 January 2018

Lovastatin effect in rat neuroblasts of the CNS: inhibition of cap-dependent translation

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00383.2010

21 January 2018

Changes in ubiquitin proteasome pathway gene expression in skeletal muscle with exercise and statins.

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00383.2010

21 January 2018

Altered expression of eukaryotic initiation factor 2B in skeletal muscle during sepsis.

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00383.2010

21 January 2018

Simvastatin attenuates hypertrophic responses induced by cardiotrophin-1 via JAK-STAT pathway in cultured cardiomyocytes

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00383.2010

21 January 2018

Phosphorylation of eukaryotic initiation factor 2 during physiological stresses which affect protein synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21224482

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro myotoxicity of the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, pravastatin, lovastatin, and simvastatin, using neonatal rat skeletal myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21224482

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Itraconazole drastically increases plasma concentrations of lovastatin and lovastatin acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/21224482

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of cholesterol synthesis by squalene synthase inhibitors does not induce myotoxicity in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/21224482

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Implication of eIF2B rather than eIF4E in the regulation of global protein synthesis by amino acids in L6 myoblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/21224482

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of the alpha-subunit of the eukaryotic initiation factor-2 (eIF2alpha) reduces protein synthesis and enhances apoptosis in response to proteasome inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/21224482

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Simvastatin reduces insulin-like growth factor-1 signaling in differentiating C2C12 mouse myoblast cells in an HMG-CoA reductase inhibition-independent manner

1 reference

https://pubmed.ncbi.nlm.nih.gov/21224482

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduction of protein synthesis and statin-induced cardiomyocyte cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/21224482

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1152/AJPENDO.00383.2010

1 reference

Europe PubMed Central

4 August 2017

1 reference

Europe PubMed Central

4 August 2017

1 reference

Europe PubMed Central

4 August 2017

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