(Q34719637)

4 August 2017

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title

Perspectives on mammalian cardiovascular aging: humans to molecules (English)

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4 August 2017

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1

Edward G Lakatta

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4 August 2017

Steven J Sollott

2

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4 August 2017

1 August 2002

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Comparative Biochemistry and Physiology. Part A: Molecular and Integrative Physiology

4 August 2017

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4 August 2017

132

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4 August 2017

4

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4 August 2017

699-721

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Myocyte cell loss and myocyte cellular hyperplasia in the hypertrophied aging rat heart

4 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

TGF-beta induces bimodal proliferation of connective tissue cells via complex control of an autocrine PDGF loop

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Prevention of ischemia-induced ventricular fibrillation by omega 3 fatty acids

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Transforming growth factor-beta in disease: the dark side of tissue repair

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Age-dependent changes in the beta-adrenoceptor-G-protein(s)-adenylyl cyclase system in human right atrium.

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Aging, cardiac proenkephalin mRNA and enkephalin peptides in the Fisher 344 rat

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Nitric oxide, atrial natriuretic peptide, and cyclic GMP inhibit the growth-promoting effects of norepinephrine in cardiac myocytes and fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Angiotensin II induces fibronectin expression associated with cardiac fibrosis in the rat

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Detection of hydroxyl radical in the mitochondria of ischemic-reperfused myocardium by trapping with salicylate

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Thyroid hormone influences beta myosin heavy chain (beta MHC) expression

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Changes in myosin isoenzymes, ATPase activity, and contraction duration in rat cardiac muscle with aging can be modulated by thyroxine

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Collagen accumulation in heart ventricles as a function of growth and aging

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Characterization of promoter elements of the rabbit cardiac sarcoplasmic reticulum Ca(2+)-ATPase gene required for expression in cardiac muscle cells

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Impact of age on the cardiovascular response to dynamic upright exercise in healthy men and women.

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Role of the extracellular matrix in age-related modifications of the rat aorta. Ultrastructural, morphometric, and enzymatic evaluations

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Studies of sarcoplasmic reticulum function and contraction duration in young adult and aged rat myocardium

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Chemiluminescent real time imaging of post-ischemic oxygen free radicals formation in livers isolated from young and old rats

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Echocardiographic assessment of a normal adult aging population

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Analysis of thyroid hormone effects on myosin heavy chain gene expression in cardiac and soleus muscles using a novel dot-blot mRNA assay.

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Modulation of dihydropyridine-sensitive calcium channels in heart cells by fish oil fatty acids

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Elucidating the molecular mechanism of the permeability transition pore and its role in reperfusion injury of the heart

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Bioenergetics in aging

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Aging and arteriosclerosis. I. Development of myointimal hyperplasia after endothelial injury

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Aortic endothelial and subendothelial cells in experimental hypertension and aging

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Aging-induced up-regulation of nuclear binding activities of oxidative stress responsive NF-kB transcription factor in mouse cardiac muscle.

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Inhibition of NADH-linked mitochondrial respiration by 4-hydroxy-2-nonenal

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Cardiovascular effects of aging. Interrelationships of aortic, left ventricular, and left atrial function

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Hormonal modulation of a gene injected into rat heart in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Diminished inotropic response of aged myocardium to catecholamines

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Deficient neuroendocrine regulation of the cardiovascular system with advancing age in healthy humans

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Cardiovascular regulatory mechanisms in advanced age.

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Increased expression of matrix metalloproteinase-2 in the thickened intima of aged rats

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Impaired cell shortening and relengthening with increased pacing frequency are intrinsic to the senescent mouse cardiomyocyte

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Expression of sarcoplasmic reticulum Ca(2+)-ATPase and calsequestrin genes in rat heart during ontogenic development and aging.

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Myocardial retinoid X receptor, thyroid hormone receptor, and myosin heavy chain gene expression in the rat during adult aging

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Cardiac reperfusion injury: aging, lipid peroxidation, and mitochondrial dysfunction

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Declines in mitochondrial respiration during cardiac reperfusion: age-dependent inactivation of alpha-ketoglutarate dehydrogenase

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Production of transforming growth factor beta 1 during repair of arterial injury

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Evidence for an age-related dysfunction in the antiproliferative response to transforming growth factor-beta in vascular smooth muscle cells

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Dietary fish oil prevents ventricular fibrillation following coronary artery occlusion and reperfusion

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Reversal of the arrhythmogenic effects of long-term saturated fatty acid intake by dietary n-3 and n-6 polyunsaturated fatty acids.

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Dietary lipid modulation of ventricular fibrillation threshold in the marmoset monkey

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

The influence of age and dietary fat in an animal model of sudden cardiac death

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Influence of dietary lipids on arrhythmias and infarction after coronary artery ligation in rats.

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Decrease in the rate of RNA and protein synthesis and degradation in the myocardium under long-term compensatory hyperfunction and on aging

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Differential expression of metalloproteinase and tissue inhibitor of metalloproteinase genes in aged human fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

A calcineurin-dependent transcriptional pathway for cardiac hypertrophy

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Influence of mitochondrial radical formation on energy-linked respiration

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Gender differences and aging: effects on the human heart

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Cardiomyopathy of the aging human heart. Myocyte loss and reactive cellular hypertrophy

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Intracellular calcium transients and developed tension in rat heart muscle. A mechanism for the negative interval-strength relationship

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Omega 3 polyunsaturated fatty acid modulates dihydropyridine effects on L-type Ca2+ channels, cytosolic Ca2+, and contraction in adult rat cardiac myocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Structure and function changes in the endocrine pancreas of aging rats with reference to the modulating effects of exercise and caloric restriction

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Basal and stimulated plasma atrial natriuretic peptide (ANP) concentrations and cardiac ANP contents in old and young rats

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Aging of the vascular wall and atherogenesis: role of the elastin-laminin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Cardiac performance in the unanesthetized senescent male rat.

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Rapamycin selectively inhibits angiotensin II-induced increase in protein synthesis in cardiac myocytes in vitro. Potential role of 70-kD S6 kinase in angiotensin II-induced cardiac hypertrophy

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Decrease with senescence in the norepinephrine-induced phosphorylation of myofilament proteins in isolated rat cardiac myocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Changes in superoxide radical and lipid peroxide formation in the brain, heart and liver during the lifetime of the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Forskolin activation of adenylate cyclase in rat myocardium with age: effects of guanine nucleotide analogs

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Restoration of diastolic function in senescent rat hearts through adenoviral gene transfer of sarcoplasmic reticulum Ca(2+)-ATPase.

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Activation of 72-kDa type IV collagenase/gelatinase by normal fibroblasts in collagen lattices is mediated by integrin receptors but is not related to lattice contraction

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Effects of age on c-fos and c-myc gene expression in response to hemodynamic stress in isolated, perfused rat hearts

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Effects of age, sex, and breeding status on the rat heart

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Alteration of growth responses in established cardiac pressure overload hypertrophy in rats with aortic banding

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Ca2+-Mg2+ ATPase of mouse cardiac sarcoplasmic reticulum is affected by membrane n-6 and n-3 polyunsaturated fatty acid content

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

The calcium uptake of the rat heart sarcoplasmic reticulum is altered by dietary lipid

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Effects of age and aerobic capacity on arterial stiffness in healthy adults

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Kappa and delta opioid receptor stimulation affects cardiac myocyte function and Ca2+ release from an intracellular pool in myocytes and neurons

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Resting and active mechanical properties of trabeculae carneae from aged male rats

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Clenbuterol induces cardiac hypertrophy with normal functional, morphological and molecular features

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Age-associated changes in beta-adrenergic modulation on rat cardiac excitation-contraction coupling

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Age-associated reductions in cardiac beta1- and beta2-adrenergic responses without changes in inhibitory G proteins or receptor kinases

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Mechanical properties of myocardium from hypertrophied rat hearts. A comparison between hypertrophy induced by senescence and by aortic banding

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

Reactive oxygen species (ROS)-induced ROS release: a new phenomenon accompanying induction of the mitochondrial permeability transition in cardiac myocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1095-6433%2802%2900124-1

7 January 2021

10.1016/S1095-6433(02)00124-1

Identifiers

DOI

1 reference

4 August 2017

1 reference

PubMed ID

12095857