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Protein aggregation in Huntington's disease.
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12106904
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12106904%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
review article
1 reference
stated in
Europe PubMed Central
title
Protein aggregation in Huntington's disease
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12106904
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12106904%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
main subject
Huntington's disease
0 references
protein aggregation
1 reference
based on heuristic
inferred from title
author
Guylaine Hoffner
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12106904
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12106904%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
Philippe Djian
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12106904
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12106904%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
author name string
Guylaine Hoffner
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12106904
retrieved
4 August 2017
Philippe Djian
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12106904
retrieved
4 August 2017
publication date
1 April 2002
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12106904
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12106904%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
published in
Biochimie
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12106904
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12106904%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
volume
84
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12106904
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12106904%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
issue
4
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12106904
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12106904%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
page(s)
273-278
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12106904
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12106904%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
cites work
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901398-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901398-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901398-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human genetic diseases due to codon reiteration: relationship to an evolutionary mechanism
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901398-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Glutamine repeats as polar zippers: their possible role in inherited neurodegenerative diseases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901398-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Incorporation of glutamine repeats makes protein oligomerize: implications for neurodegenerative diseases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901398-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901398-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901398-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Formic acid dissolves aggregates of an N-terminal huntingtin fragment containing an expanded polyglutamine tract: applying to quantification of protein components of the aggregates
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901398-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Amyloid formation by mutant huntingtin: threshold, progressivity and recruitment of normal polyglutamine proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901398-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Amyloid-like inclusions in Huntington's disease.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901398-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transglutaminase aggregates huntingtin into nonamyloidogenic polymers, and its enzymatic activity increases in Huntington's disease brain nuclei
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901398-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transglutaminase activity in rat brain: characterization, distribution, and changes with age.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901398-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differential expression of multiple transglutaminases in human brain. Increased expression and cross-linking by transglutaminases 1 and 2 in Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901398-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Neurodegenerative diseases and transglutaminase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901398-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Peptides containing glutamine repeats as substrates for transglutaminase-catalyzed cross-linking: relevance to diseases of the nervous system
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901398-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tissue transglutaminase-catalyzed formation of high-molecular-weight aggregates in vitro is favored with long polyglutamine domains: a possible mechanism contributing to CAG-triplet diseases.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901398-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transglutaminase-catalyzed inactivation of glyceraldehyde 3-phosphate dehydrogenase and alpha-ketoglutarate dehydrogenase complex by polyglutamine domains of pathological length
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901398-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transglutaminase action imitates Huntington's disease: selective polymerization of Huntingtin containing expanded polyglutamine.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901398-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
N(epsilon)-(gamma-L-glutamyl)-L-lysine (GGEL) is increased in cerebrospinal fluid of patients with Huntington's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901398-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tissue transglutaminase does not contribute to the formation of mutant huntingtin aggregates
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901398-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Intranuclear neuronal inclusions in Huntington's disease and dentatorubral and pallidoluysian atrophy: correlation between the density of inclusions and IT15 CAG triplet repeat length
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901398-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Huntington's disease intranuclear inclusions contain truncated, ubiquitinated huntingtin protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901398-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901398-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901398-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901398-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identities of sequestered proteins in aggregates from cells with induced polyglutamine expression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901398-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901398-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901398-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901398-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901398-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901398-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Impairment of the ubiquitin-proteasome system by protein aggregation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901398-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901398-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A cellular model that recapitulates major pathogenic steps of Huntington's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901398-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901398-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutant protein in Huntington disease is resistant to proteolysis in affected brain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901398-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification and localization of huntingtin in brain and human lymphoblastoid cell lines with anti-fusion protein antibodies
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901398-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Huntingtin is present in the nucleus, interacts with the transcriptional corepressor C-terminal binding protein, and represses transcription
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901398-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901398-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Aggresomes: a cellular response to misfolded proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901398-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Intracellular aggregation of polypeptides with expanded polyglutamine domain is stimulated by stress-activated kinase MEKK1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901398-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0300-9084(02)01398-6
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12106904
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12106904%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
PubMed publication ID
12106904
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12106904
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12106904%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
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