(Q34741545)

4 August 2017

1 reference

title

The genetic basis of variability in drug responses (English)

1 reference

4 August 2017

1

Dan M Roden

1 reference

4 August 2017

Alfred L George

2

1 reference

4 August 2017

1 January 2002

1 reference

Nature Reviews Drug Discovery

4 August 2017

1 reference

4 August 2017

1

1 reference

4 August 2017

37-44

1 reference

4 August 2017

1

1 reference

https://scigraph.springernature.com/pub.10.1038/nrd705

4 August 2017

0 references

cites work

Monitoring of adverse drug events in hospitals

1 reference

Adverse drug events in hospitalized patients. Excess length of stay, extra costs, and attributable mortality.

31 March 2020

1 reference

Incidence and costs of adverse drug reactions during hospitalisation: computerised monitoring versus stimulated spontaneous reporting.

31 March 2020

1 reference

Postmarketing surveillance and adverse drug reactions: current perspectives and future needs.

31 March 2020

1 reference

Potential role of pharmacogenomics in reducing adverse drug reactions: a systematic review

31 March 2020

1 reference

Genetic control of isoniazid metabolism in man

31 March 2020

1 reference

Pharmacogenomics: translating functional genomics into rational therapeutics

31 March 2020

1 reference

Pharmacogenetics and the practice of medicine

31 March 2020

1 reference

Pharmacogenetics and adverse drug reactions

31 March 2020

1 reference

Effect of acetylator phenotype on the rate at which procainamide induces antinuclear antibodies and the lupus syndrome

31 March 2020

1 reference

Polymorphisms of N-acetyltransferase genes

31 March 2020

1 reference

Polymorphic hydroxylation of Debrisoquine in man.

31 March 2020

1 reference

Defective N-oxidation of sparteine in man: A new pharmacogenetic defect

31 March 2020

1 reference

Role of P450IID6, the target of the sparteine-debrisoquin oxidation polymorphism, in the metabolism of imipramine

31 March 2020

1 reference

The role of genetically determined polymorphic drug metabolism in the beta-blockade produced by propafenone

31 March 2020

1 reference

Oxidation phenotype--a major determinant of metoprolol metabolism and response

31 March 2020

1 reference

Molecular mechanisms of genetic polymorphisms of drug metabolism

31 March 2020

1 reference

Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications

31 March 2020

1 reference

Effect of genetic differences in omeprazole metabolism on cure rates for Helicobacter pylori infection and peptic ulcer

31 March 2020

1 reference

Methyltransferase pharmacogenetics

31 March 2020

1 reference

Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects

31 March 2020

1 reference

Genetic Aspects of Succinylcholine Sensitivity

31 March 2020

1 reference

Tricyclic antidepressant plasma levels after fluoxetine addition.

31 March 2020

1 reference

Inhibition of P-glycoprotein-mediated drug transport: A unifying mechanism to explain the interaction between digoxin and quinidine [seecomments]

31 March 2020

1 reference

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors

31 March 2020

1 reference

Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

31 March 2020

1 reference

Identification of functionally variant MDR1 alleles among European Americans and African Americans

31 March 2020

1 reference

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

31 March 2020

1 reference

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression.

31 March 2020

1 reference

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

31 March 2020

1 reference

Orphan receptor promiscuity in the induction of cytochromes p450 by xenobiotics

31 March 2020

1 reference

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

31 March 2020

1 reference

Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR

31 March 2020

1 reference

Humanized xenobiotic response in mice expressing nuclear receptor SXR.

31 March 2020

1 reference

Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease

31 March 2020

1 reference

A common polymorphism associated with antibiotic-induced cardiac arrhythmia

31 March 2020

1 reference

Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment

31 March 2020

1 reference

KVLQT1 C-terminal missense mutation causes a forme fruste long-QT syndrome

31 March 2020

1 reference

Evidence for a cardiac ion channel mutation underlying drug-induced QT prolongation and life-threatening arrhythmias

31 March 2020

1 reference

An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels

31 March 2020

1 reference

ACE (I/D) genotype as a predictor of the magnitude and duration of the response to an ACE inhibitor drug (enalaprilat) in humans

31 March 2020

1 reference

Pharmacogenetic interactions between beta-blocker therapy and the angiotensin-converting enzyme deletion polymorphism in patients with congestive heart failure

31 March 2020

1 reference

Genetic Control of Drug Levels in Man: Antipyrine

31 March 2020

1 reference

Functional discovery via a compendium of expression profiles

31 March 2020

1 reference

A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms

31 March 2020

1 reference

Haplotype variation and linkage disequilibrium in 313 human genes

31 March 2020

1 reference

Notes from the SNP vs. haplotype front

31 March 2020

1 reference

Human thiopurine methyltransferase pharmacogenetics. Kindred with a terminal exon splice junction mutation that results in loss of activity

31 March 2020

1 reference

Genetic polymorphism of thiopurine methyltransferase and its clinical relevance for childhood acute lymphoblastic leukemia

31 March 2020

1 reference

Ethical and legal implications of pharmacogenomics

31 March 2020

1 reference

Consent and privacy in pharmacogenetic testing.

31 March 2020

1 reference

Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure

31 March 2020

1 reference

Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the survival and ventricular enlargement trial. The SAVE Investigators

31 March 2020

1 reference

Black Americans have an increased rate of angiotensin converting enzyme inhibitor-associated angioedema

31 March 2020

1 reference

Recurrent angiotensin-converting enzyme inhibitor--associated angioedema

31 March 2020

1 reference

Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)

31 March 2020

1 reference

Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group

31 March 2020

1 reference

HMG-CoA reductase inhibitors and myotoxicity

31 March 2020

1 reference

Genetic variation as a guide to drug development

31 March 2020

1 reference

The effects of genetic polymorphisms of CYP2C9 and CYP2C19 on phenytoin metabolism in Japanese adult patients with epilepsy: studies in stereoselective hydroxylation and population pharmacokinetics

31 March 2020

1 reference

Mephenytoin hydroxylation deficiency in Caucasians: frequency of a new oxidative drug metabolism polymorphism

31 March 2020

1 reference

Stereoselective disposition of carvedilol is determined by CYP2D6

31 March 2020

1 reference

Hypotensive response to debrisoquine and hydroxylation phenotype

31 March 2020

1 reference

Reduced thiopurine methyltransferase activity and development of side effects of azathioprine treatment in patients with rheumatoid arthritis

31 March 2020

1 reference

The effect of polymorphisms of the beta(2)-adrenergic receptor on the response to regular use of albuterol in asthma

31 March 2020

1 reference

Novel polymorphisms in promoter region of atp binding cassette transporter gene and plasma lipids, severity, progression, and regression of coronary atherosclerosis and response to therapy

31 March 2020

1 reference

The Role of a Common Variant of the Cholesteryl Ester Transfer Protein Gene in the Progression of Coronary Atherosclerosis

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRD705

1 reference

4 August 2017

1 reference

PubMed ID

12119608