(Q34747143)

4 August 2017

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title

Mitochondria and ceramide: intertwined roles in regulation of apoptosis (English)

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4 August 2017

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1 reference

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4

Yusuf A Hannun

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4 August 2017

Helene Birbes

1

1 reference

PubMed ID

12123710

4 August 2017

Samer El Bawab

series ordinal

2

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PubMed ID

12123710

4 August 2017

Lina M Obeid

series ordinal

3

1 reference

4 August 2017

1 January 2002

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Advances in Enzyme Regulation

4 August 2017

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4 August 2017

42

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4 August 2017

113-129

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Ceramide signalling and the immune response

4 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Early transitory rise in intracellular pH leads to Bax conformation change during ceramide-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

FAS activation induces dephosphorylation of SR proteins; dependence on the de novo generation of ceramide and activation of protein phosphatase 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Cytokine response modifier A (CrmA) inhibits ceramide formation in response to tumor necrosis factor (TNF)-alpha: CrmA and Bcl-2 target distinct components in the apoptotic pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

p53-dependent ceramide response to genotoxic stress

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

IAP family proteins--suppressors of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Biochemical characterization of the reverse activity of rat brain ceramidase. A CoA-independent and fumonisin B1-insensitive ceramide synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Molecular cloning and characterization of a human mitochondrial ceramidase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Direct Effect of Ceramide on the Mitochondrial Electron Transport Chain Leads to Generation of Reactive Oxygen Species

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Regulated targeting of BAX to mitochondria.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Regulation of protein kinase C by sphingosine and lysosphingolipids

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Ceramide in the eukaryotic stress response

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Functions of ceramide in coordinating cellular responses to stress

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

The biochemistry of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Effect of chemically well-defined sphingosine and its N-methyl derivatives on protein kinase C and src kinase activities

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Bcl-2 phosphorylation required for anti-apoptosis function

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Involvement of yeast sphingolipids in the heat stress response of Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Translocation of SAPK/JNK to mitochondria and interaction with Bcl-x(L) in response to DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Phosphatidic acid is a potent and selective inhibitor of protein phosphatase 1 and an inhibitor of ceramide-mediated responses

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Molecular cloning and characterization of a full-length complementary DNA encoding human acid ceramidase. Identification Of the first molecular lesion causing Farber disease

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Ceramide and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Agents that reverse multidrug resistance, tamoxifen, verapamil, and cyclosporin A, block glycosphingolipid metabolism by inhibiting ceramide glycosylation in human cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Ceramide inactivates cellular protein kinase Calpha

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Activation of the de novo biosynthesis of sphingolipids mediates angiotensin II type 2 receptor-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Cytochrome c deficiency causes embryonic lethality and attenuates stress-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Ataxia telangiectasia-mutated gene product inhibits DNA damage-induced apoptosis via ceramide synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Expression of glucosylceramide synthase, converting ceramide to glucosylceramide, confers adriamycin resistance in human breast cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Inhibition of the neutral magnesium-dependent sphingomyelinase by glutathione

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Cardiolipin provides specificity for targeting of tBid to mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Mitochondrial translocation of protein kinase C delta in phorbol ester-induced cytochrome c release and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Regulation of phospholipase C delta1 by sphingosine

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Enzymes of ceramide biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Conversion of dihydroceramide to ceramide occurs at the cytosolic face of the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Ceramide induces apoptosis via CPP32 activation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Programmed cell death induced by ceramide

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Sphingosine kinase: a mediator of vital cellular functions

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Acid sphingomyelinase-deficient mice mimic the neurovisceral form of human lysosomal storage disease (Niemann-Pick disease).

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

The proapoptotic BH3-only protein bim is expressed in hematopoietic, epithelial, neuronal, and germ cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Functional consequences of the sustained or transient activation by Bax of the mitochondrial permeability transition pore

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Involvement of de novo ceramide biosynthesis in lymphotoxin-induced oligodendrocyte death

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Stereoselectivity of induction of the retinoblastoma gene product (pRb) dephosphorylation by D-erythro-sphingosine supports a role for pRb in growth suppression by sphingosine

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Sphingomyelin-derived lipids differentially regulate the extracellular signal-regulated kinase 2 (ERK-2) and c-Jun N-terminal kinase (JNK) signal cascades in airway smooth muscle

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Sphingosine 1-phosphate signalling in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

The differential regulation of cyclic AMP by sphingomyelin-derived lipids and the modulation of sphingolipid-stimulated extracellular signal regulated kinase-2 in airway smooth muscle

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Implication of mitochondrial hydrogen peroxide generation in ceramide-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Ceramide mediates the apoptotic response of WEHI 231 cells to anti-immunoglobulin, corticosteroids and irradiation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

c-Jun is a downstream target for ceramide-activated protein phosphatase in A431 cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Ceramide induces cytochrome c release from isolated mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2A

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Suppression of bcl-2 gene expression by sphingosine in the apoptosis of human leukemic HL-60 cells during phorbol ester-induced terminal differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Different effects of sphingosine, R59022 and anionic amphiphiles on two diacylglycerol kinase isozymes purified from porcine thymus cytosol

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Characterization of acidic and neutral sphingomyelinase activities in crude extracts of HL-60 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Partial purification and characterization of sphingosine N-acyltransferase (ceramide synthase) from bovine liver mitochondrion-rich fraction.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Proapoptotic BH3-only Bcl-2 family members induce cytochrome c release, but not mitochondrial membrane potential loss, and do not directly modulate voltage-dependent anion channel activity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

prICE: a downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Sphingolipid metabolism and cell growth regulation.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Functions of a new family of sphingosine-1-phosphate receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Ceramidase Deficiency in Farber's Disease (Lipogranulomatosis)

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Molecular characterization of mitochondrial apoptosis-inducing factor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Molecular cloning of the full-length cDNA encoding mouse neutral ceramidase. A novel but highly conserved gene family of neutral/alkaline ceramidases

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Sphingomyelin breakdown and cell fate

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Caspases: enemies within

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Assessment of the extracellular and intracellular actions of sphingosine 1-phosphate by using the p42/p44 mitogen-activated protein kinase cascade as a model

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Heat-induced elevation of ceramide in Saccharomyces cerevisiae via de novo synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Involvement of de novo ceramide biosynthesis in tumor necrosis factor-alpha/cycloheximide-induced cerebral endothelial cell death.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Bcl-2 interrupts the ceramide-mediated pathway of cell death.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Expression of neutral sphingomyelinase identifies a distinct pool of sphingomyelin involved in apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Kinase suppressor of Ras is ceramide-activated protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

Akt regulates cell survival and apoptosis at a postmitochondrial level

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900026-7

7 January 2021

10.1016/S0065-2571(01)00026-7

Identifiers

DOI

1 reference

4 August 2017

1 reference

PubMed ID

12123710