(Q34768821)

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Animal models of epilepsy for the development of antiepileptogenic and disease-modifying drugs. A comparison of the pharmacology of kindling and post-status epilepticus models of temporal lobe epilepsy

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Europe PubMed Central

4 August 2017

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Europe PubMed Central

Animal models of epilepsy for the development of antiepileptogenic and disease-modifying drugs. A comparison of the pharmacology of kindling and post-status epilepticus models of temporal lobe epilepsy (English)

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Europe PubMed Central

4 August 2017

status epilepticus

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author name string

Wolfgang Löscher

1

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Europe PubMed Central

4 August 2017

publication date

1 June 2002

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Europe PubMed Central

4 August 2017

Epilepsy Research

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Europe PubMed Central

4 August 2017

50

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Europe PubMed Central

4 August 2017

105-123

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Europe PubMed Central

4 August 2017

1-2

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Europe PubMed Central

4 August 2017

Vigabatrin protects against hippocampal damage but is not antiepileptogenic in the lithium-pilocarpine model of temporal lobe epilepsy

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Causes of epilepsy: contributions of the Rochester epidemiology project.

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Pharmacological characterization of the 6 Hz psychomotor seizure model of partial epilepsy

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Advances in the medical treatment of epilepsy

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Comparison of valproate and phenobarbital treatment after status epilepticus in rats.

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Anticonvulsant action and long-term effects of gabapentin in the immature brain

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Is epilepsy a progressive disease? The neurobiological consequences of epilepsy

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Delayed sclerosis, neuroprotection, and limbic epileptogenesis after status epilepticus in the rat.

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Effects of the novel antiepileptic drug levetiracetam on spontaneous recurrent seizures in the rat pilocarpine model of temporal lobe epilepsy

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Progression of spontaneous seizures after status epilepticus is associated with mossy fibre sprouting and extensive bilateral loss of hilar parvalbumin and somatostatin-immunoreactive neurons.

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Tiagabine prevents seizures, neuronal damage and memory impairment in experimental status epilepticus.

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Neuroprotective effect of remacemide hydrochloride in a perforant pathway stimulation model of status epilepticus in the rat.

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Effect of lamotrigine treatment on status epilepticus-induced neuronal damage and memory impairment in rat.

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Chronic elevation of brain GABA levels beginning two days after status epilepticus does not prevent epileptogenesis in rats

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Seizure recurrence after a 1st unprovoked seizure: an extended follow-up

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Cognitive functions after pilocarpine-induced status epilepticus: changes during silent period precede appearance of spontaneous recurrent seizures

1 reference

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Kindling increases the sensitivity of rats to adverse effects of certain antiepileptic drugs

1 reference

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Use of epileptic animals for adverse effect testing

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Effects of conventional antiepileptic drugs in a model of spontaneous recurrent seizures in rats

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Suppression of pilocarpine-induced status epilepticus and the late development of epilepsy in rats

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Blockade of pilocarpine- or kainate-induced mossy fiber sprouting by cycloheximide does not prevent subsequent epileptogenesis in rats

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Supragranular mossy fiber sprouting is not necessary for spontaneous seizures in the intrahippocampal kainate model of epilepsy in the rat.

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Animal models of intractable epilepsy

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Pharmacology of glutamate receptor antagonists in the kindling model of epilepsy

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New visions in the pharmacology of anticonvulsion

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Current status and future directions in the pharmacotherapy of epilepsy

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Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations

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Responses to NMDA receptor antagonists altered by epileptogenesis

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Strategies in antiepileptic drug development: is rational drug design superior to random screening and structural variation?

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Critical re-evaluation of previous preclinical strategies for the discovery and the development of new antiepileptic drugs.

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New horizons in the development of antiepileptic drugs

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Is amygdala kindling in rats a model for drug-resistant partial epilepsy?

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Does prolonged implantation of depth electrodes predispose the brain to kindling?

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Kindling alters the anticonvulsant efficacy of phenytoin in Wistar rats

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Topiramate reduces neuronal injury after experimental status epilepticus.

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Chronic electrode implantation entails epileptiform field potentials in rat hippocampal slices, similarly to amygdala kindling.

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Effects of diazepam and diphenylhydantoin on elicited and spontaneous seizures in kindled rats: a double dissociation.

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Effects of vigabatrin treatment on status epilepticus-induced neuronal damage and mossy fiber sprouting in the rat hippocampus.

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Phenobarbital and MK-801, but not phenytoin, improve the long-term outcome of status epilepticus

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Kindling: basic mechanisms and clinical validity

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Does antiepileptic drug therapy prevent the development of "chronic" epilepsy?

1 reference

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Antiepileptogenic effects of conventional anticonvulsants in the kindling model of epilespy

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1 reference

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Do seizures cause neuronal damage in rat amygdala kindling?

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Outcome of childhood status epilepticus and lengthy febrile convulsions: findings of national cohort study

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Identifiers

10.1016/S0920-1211(02)00073-6

1 reference

Europe PubMed Central

4 August 2017

1 reference

Europe PubMed Central

4 August 2017

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