(Q34774416)

4 August 2017

title

Development and characterization of pepducins as Gs-biased allosteric agonists (English)

1 reference

4 August 2017

1 reference

Michel Bouvier

6

0 references

Brian Kobilka

7

object named as

Brian K Kobilka

1 reference

4 August 2017

4

Reynold A Panettieri

1 reference

4 August 2017

Richard Carr

1

1 reference

4 August 2017

Yang Du

2

1 reference

4 August 2017

Julie Quoyer

3

1 reference

4 August 2017

Jay M Janz

5

1 reference

4 August 2017

Jeffrey L Benovic

8

1 reference

4 August 2017

language of work or name

English

0 references

publication date

13 November 2014

1 reference

Journal of Biological Chemistry

4 August 2017

published in

1 reference

4 August 2017

volume

289

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4 August 2017

issue

52

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4 August 2017

page(s)

35668-35684

1 reference

Contemporary use of β-blockers: clinical relevance of subclassification

4 August 2017

cites work

1 reference

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Role of β-arrestins and arrestin domain-containing proteins in G protein-coupled receptor trafficking

7 July 2018

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Minireview: More than just a hammer: ligand "bias" and pharmaceutical discovery.

7 July 2018

1 reference

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Quantification of ligand bias for clinically relevant β2-adrenergic receptor ligands: implications for drug taxonomy.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276837

Regulation of β2-adrenergic receptor function by conformationally selective single-domain intrabodies.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276837

Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276837

The β-blocker Nebivolol Is a GRK/β-arrestin biased agonist

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276837

Interactions of the α-subunits of heterotrimeric G-proteins with GPCRs, effectors and RGS proteins: a critical review and analysis of interacting surfaces, conformational shifts, structural diversity and electrostatic potentials

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276837

The dynamic process of β(2)-adrenergic receptor activation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276837

Ligand-specific interactions modulate kinetic, energetic, and mechanical properties of the human β2 adrenergic receptor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276837

Turning receptors on and off with intracellular pepducins: new insights into G-protein-coupled receptor drug development

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276837

Biased signaling pathways in β2-adrenergic receptor characterized by 19F-NMR.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276837

Activation mechanism of the β2-adrenergic receptor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276837

Age and risks of FDA-approved long-acting β₂-adrenergic receptor agonists

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276837

Crystal structure of the β2 adrenergic receptor-Gs protein complex

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276837

Evolution of β-blockers: from anti-anginal drugs to ligand-directed signalling

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276837

β(2) -adrenoceptor agonists: current and future direction

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276837

Structure of a nanobody-stabilized active state of the β(2) adrenoceptor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276837

Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276837

20-HETE mediates ozone-induced, neutrophil-independent airway hyper-responsiveness in mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276837

Both hematopoietic-derived and non-hematopoietic-derived {beta}-arrestin-2 regulates murine allergic airway disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276837

The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276837

Beta-arrestins specifically constrain beta2-adrenergic receptor signaling and function in airway smooth muscle

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276837

beta-arrestin-biased agonism at the beta2-adrenergic receptor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276837

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276837

GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276837

Crystal structure of the human beta2 adrenergic G-protein-coupled receptor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276837

A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276837

Structural analogues of smoothened intracellular loops as potent inhibitors of Hedgehog pathway and cancer cell growth

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276837

Seven transmembrane receptors: something old, something new.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276837

Probing the activation-promoted structural rearrangements in preassembled receptor-G protein complexes.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276837

Targeting G protein-coupled receptor signaling in asthma

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276837

Role of the G protein-coupled receptor kinase site serine cluster in beta2-adrenergic receptor internalization, desensitization, and beta-arrestin translocation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276837

High-throughput screening of G protein-coupled receptor antagonists using a bioluminescence resonance energy transfer 1-based beta-arrestin2 recruitment assay

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276837

Real-time monitoring of receptor and G-protein interactions in living cells.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276837

Characterization of agonist stimulation of cAMP-dependent protein kinase and G protein-coupled receptor kinase phosphorylation of the beta2-adrenergic receptor using phosphoserine-specific antibodies

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276837

Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276837

Beta-arrestin-2 regulates the development of allergic asthma

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276837

Activation and inhibition of G protein-coupled receptors by cell-penetrating membrane-tethered peptides

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276837

Salmeterol-induced desensitization, internalization and phosphorylation of the human beta2-adrenoceptor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276837

Subtype-specific intracellular trafficking of alpha2-adrenergic receptors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276837

A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276837

Inverse agonist activity of beta-adrenergic antagonists.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276837

Negative antagonists promote an inactive conformation of the beta 2-adrenergic receptor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276837

beta-Arrestin: a protein that regulates beta-adrenergic receptor function

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276837

Cardioprotective effects of carvedilol, a novel beta adrenoceptor antagonist with vasodilating properties, in anaesthetised minipigs: comparison with propranolol

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276837

The Salmeterol Multicenter Asthma Research Trial: a comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol

7 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.618819

Pepducin-based intervention of thrombin-receptor signaling and systemic platelet activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.618819

Activation of human monocytes by a formyl peptide receptor 2-derived pepducin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.618819

Induction of pro-angiogenic signaling by a synthetic peptide derived from the second intracellular loop of S1P3 (EDG3).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.618819

Mechanisms of acute desensitization of the beta2AR-adenylyl cyclase pathway in human airway smooth muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.618819

Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.618819

Coupling ligand structure to specific conformational switches in the beta2-adrenoceptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.618819

Nebivolol and metoprolol for treating migraine: an advance on beta-blocker treatment?

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276837

A human airway smooth muscle cell line that retains physiological responsiveness

26 October 2018

1 reference

12 December 2020

Specific activation of Gs by synthetic peptides corresponding to an intracellular loop of the beta-adrenergic receptor

1 reference

12 December 2020

Cardioprotective potential of carvedilol

1 reference

12 December 2020

Visualization of agonist-induced sequestration and down-regulation of a green fluorescent protein-tagged beta2-adrenergic receptor

1 reference

12 December 2020

Reversing systemic inflammatory response syndrome with chemokine receptor pepducins

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M114.618819

1 reference

release_cstq3bk4hbde7mzxuz7kuabuga

4 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/cstq3bk4hbde7mzxuz7kuabuga

24 November 2022

mapped directly with Wikidata item

PMC publication ID

4276837

1 reference

4 August 2017

1 reference