(Q34785752)

4 August 2017

RAF inhibitor-induced KSR1/B-RAF binding and its effects on ERK cascade signaling (English)

1 reference

4 August 2017

Melissa M McKay

1

1 reference

4 August 2017

Daniel A Ritt

series ordinal

2

1 reference

4 August 2017

Deborah K Morrison

series ordinal

3

1 reference

4 August 2017

language of work or name

English

0 references

publication date

31 March 2011

1 reference

4 August 2017

1 reference

4 August 2017

21

1 reference

4 August 2017

563-568

1 reference

4 August 2017

7

1 reference

Gatekeeper mutations mediate resistance to BRAF-targeted therapies.

4 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075323

RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075323

Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075323

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075323

Impact of feedback phosphorylation and Raf heterodimerization on normal and mutant B-Raf signaling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075323

A dimerization-dependent mechanism drives RAF catalytic activation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075323

KSR2 is a calcineurin substrate that promotes ERK cascade activation in response to calcium signals

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075323

Signaling dynamics of the KSR1 scaffold complex

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075323

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075323

CK2 Is a component of the KSR1 scaffold complex that contributes to Raf kinase activation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075323

The molecular scaffold KSR1 regulates the proliferative and oncogenic potential of cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075323

Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075323

Solution structure and functional analysis of the cysteine-rich C1 domain of kinase suppressor of Ras (KSR)

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075323

Identification of B-KSR1, a novel brain-specific isoform of KSR1 that functions in neuronal signaling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075323

Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075323

Identification of constitutive and ras-inducible phosphorylation sites of KSR: implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpression

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075323

Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075323

KSR, a novel protein kinase required for RAS signal transduction

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075323

Caspase-dependent cleavage disrupts the ERK cascade scaffolding function of KSR1.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075323

Activation of c-Raf-1 by Ras and Src through different mechanisms: activation in vivo and in vitro

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075323

10.1016/J.CUB.2011.02.033

26 October 2018

Identifiers

DOI

1 reference

4 August 2017

1 reference

4 August 2017

1 reference