(Q34795775)

4 August 2017

title

Protective role of olesoxime against wild-type α-synuclein-induced toxicity in human neuronally differentiated SHSY-5Y cells (English)

1 reference

4 August 2017

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C Gouarné

1

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4 August 2017

J Tracz

2

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4 August 2017

M Giraudon Paoli

3

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4 August 2017

V Deluca

4

1 reference

4 August 2017

M Seimandi

5

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4 August 2017

G Tardif

6

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4 August 2017

M Xilouri

7

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4 August 2017

L Stefanis

8

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4 August 2017

T Bordet

9

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4 August 2017

R M Pruss

10

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4 August 2017

language of work or name

English

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publication date

1 December 2014

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British Journal of Pharmacology

4 August 2017

published in

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4 August 2017

volume

172

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4 August 2017

issue

1

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4 August 2017

page(s)

235-245

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describes a project that uses

4 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4280980/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS.

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8 July 2018

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Olesoxime prevents microtubule-targeting drug neurotoxicity: selective preservation of EB comets in differentiated neuronal cells.

8 July 2018

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Olesoxime (cholest-4-en-3-one, oxime): analgesic and neuroprotective effects in a rat model of painful peripheral neuropathy produced by the chemotherapeutic agent, paclitaxel

8 July 2018

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Inducible over-expression of wild type alpha-synuclein in human neuronal cells leads to caspase-dependent non-apoptotic death

8 July 2018

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8 July 2018

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Specific antinociceptive activity of cholest-4-en-3-one, oxime (TRO19622) in experimental models of painful diabetic and chemotherapy-induced neuropathy

8 July 2018

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8 July 2018

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Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain

8 July 2018

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Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis

8 July 2018

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Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

8 July 2018

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alpha-Synuclein budding yeast model: toxicity enhanced by impaired proteasome and oxidative stress

8 July 2018

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alpha-Synuclein locus triplication causes Parkinson's disease

8 July 2018

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alpha-synuclein promotes mitochondrial deficit and oxidative stress

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Olesoxime (TRO19622): A Novel Mitochondrial-Targeted Neuroprotective Compound

8 July 2018

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Alpha-synuclein alters proteasome function, protein synthesis, and stationary phase viability.

21 January 2018

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21 January 2018

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Selenomethionine prevents degeneration induced by overexpression of wild-type human alpha-synuclein during differentiation of neuroblastoma cells

21 January 2018

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Olesoxime accelerates myelination and promotes repair in models of demyelination.

21 January 2018

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Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death.

21 January 2018

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Inositol stereoisomers stabilize an oligomeric aggregate of Alzheimer amyloid beta peptide and inhibit abeta -induced toxicity.

21 January 2018

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Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity

21 January 2018

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21 January 2018

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21 January 2018

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A phase II−III trial of olesoxime in subjects with amyotrophic lateral sclerosis

21 January 2018

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21 January 2018

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Multiple agents rescue PC12 cells from serum-free cell death by translation- and transcription-independent mechanisms

21 January 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/25220617

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Olesoxime delays muscle denervation, astrogliosis, microglial activation and motoneuron death in an ALS mouse model

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25220617

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1111/BPH.12939

1 reference

4 August 2017

1 reference

4 August 2017

1 reference