(Q34800544)

4 August 2017

title

The heparin-binding domain of IGFBP-2 has insulin-like growth factor binding-independent biologic activity in the growing skeleton (English)

1 reference

4 August 2017

1 reference

5

Ernesto Canalis

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Mary L. Bouxsein

6

object named as

Mary L Bouxsein

1 reference

4 August 2017

Masanobu Kawai

1

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4 August 2017

Anne C Breggia

2

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4 August 2017

Victoria E DeMambro

3

1 reference

4 August 2017

Xinchun Shen

4

1 reference

4 August 2017

Ernesto Canalis

5

1 reference

4 August 2017

Wesley G Beamer

7

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4 August 2017

David R Clemmons

8

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4 August 2017

Clifford J Rosen

9

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4 August 2017

language of work or name

English

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publication date

3 March 2011

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4 August 2017

number of pages

11

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Journal of Biological Chemistry

inferred from page(s)

published in

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4 August 2017

volume

286

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4 August 2017

issue

16

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4 August 2017

page(s)

14670-14680

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Antidiabetic effects of IGFBP2, a leptin-regulated gene

4 August 2017

cites work

1 reference

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Angiopoietin-like 5 and IGFBP2 stimulate ex vivo expansion of human cord blood hematopoietic stem cells as assayed by NOD/SCID transplantation

8 July 2018

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Insulin growth factor-binding protein 2 is a candidate biomarker for PTEN status and PI3K/Akt pathway activation in glioblastoma and prostate cancer

8 July 2018

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IGF-II and IGFBP-2 differentially regulate PTEN in human breast cancer cells

8 July 2018

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8 July 2018

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Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity

8 July 2018

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IGF-binding protein-2 protects against the development of obesity and insulin resistance

8 July 2018

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PTEN-deficient intestinal stem cells initiate intestinal polyposis

8 July 2018

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Functional interaction between peroxisome proliferator-activated receptor gamma and beta-catenin

8 July 2018

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Molecular bases of the regulation of bone remodeling by the canonical Wnt signaling pathway.

8 July 2018

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Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase

8 July 2018

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PTEN-induction in U251 glioma cells decreases the expression of insulin-like growth factor binding protein-2.

8 July 2018

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Insulin-like growth factor binding protein-2 binding to extracellular matrix plays a critical role in neuroblastoma cell proliferation, migration, and invasion

8 July 2018

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Regulation of osteoblastogenesis and bone mass by Wnt10b

8 July 2018

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Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling

8 July 2018

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Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2.

8 July 2018

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8 July 2018

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Circulating levels of IGF-1 directly regulate bone growth and density

8 July 2018

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Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta-catenin

8 July 2018

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Inhibition of adipogenesis by Wnt signaling

8 July 2018

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Insulin-like growth factor binding protein 2 is a growth inhibitory protein conserved in zebrafish

8 July 2018

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The insulin-like growth factor-binding protein (IGFBP) superfamily

8 July 2018

1 reference

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Basic fibroblast growth factor induces proteolysis of secreted and cell membrane-associated insulin-like growth factor binding protein-2 in human neuroblastoma cells

8 July 2018

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Insulin-like growth factor system abnormalities in hepatitis C-associated osteosclerosis. Potential insights into increasing bone mass in adults

8 July 2018

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Insulin-like growth factor binding protein-2 binds to cell surface proteoglycans in the rat brain olfactory bulb.

8 July 2018

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Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

8 July 2018

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Insulin-like growth factors and their binding proteins: biological actions

8 July 2018

1 reference

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Elevated levels of insulin-like growth factor-binding protein-2 in the serum of prostate cancer patients

8 July 2018

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Growth inhibition in giant growth hormone transgenic mice by overexpression of insulin-like growth factor-binding protein-2.

8 July 2018

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Subcutaneous administration of insulin-like growth factor (IGF)-II/IGF binding protein-2 complex stimulates bone formation and prevents loss of bone mineral density in a rat model of disuse osteoporosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.193334

Skeletal unloading induces resistance to insulin-like growth factor-I (IGF-I) by inhibiting activation of the IGF-I signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.193334

Inhibition of phosphatidylinositol 3-kinase and p70S6 kinase blocks osteogenic protein-1 induction of alkaline phosphatase activity in fetal rat calvaria cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.193334

Selective alterations in organ sizes in mice with a targeted disruption of the insulin-like growth factor binding protein-2 gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.193334

High serum IGFBP-2 is predictive of increased bone turnover in aging men and women

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.193334

Potentiating role of IGFBP-2 on IGF-II-stimulated alkaline phosphatase activity in differentiating osteoblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.193334

Insulin-like growth factor-binding protein-2 (IGFBP-2) overexpression negatively regulates bone size and mass, but not density, in the absence and presence of growth hormone/IGF-I excess in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.193334

Role of IGF-I signaling in regulating osteoclastogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.193334

Targeted overexpression of insulin-like growth factor I to osteoblasts of transgenic mice: increased trabecular bone volume without increased osteoblast proliferation

21 January 2018

1 reference

12 December 2020

Insulin and IGF-1 stimulate the beta-catenin pathway through two signalling cascades involving GSK-3beta inhibition and Ras activation

1 reference

12 December 2020

Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization

1 reference

12 December 2020

Binding of insulin-like growth factor (IGF) I or II to IGF-binding protein-2 enables it to bind to heparin and extracellular matrix

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M110.193334

1 reference

4 August 2017

1 reference

4 August 2017

1 reference