(Q34810230)

4 August 2017

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title

WASp in immune-system organization and function (English)

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4 August 2017

Adrian J Thrasher

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publication date

1 September 2002

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Nature Reviews Immunology

4 August 2017

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4 August 2017

2

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4 August 2017

635-646

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4 August 2017

9

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Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization

4 August 2017

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Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott-Aldrich syndrome

21 January 2018

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Direct interaction of the Wiskott-Aldrich syndrome protein with the GTPase Cdc42

21 January 2018

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21 January 2018

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WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac

21 January 2018

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Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex

21 January 2018

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Bee1, a yeast protein with homology to Wiscott-Aldrich syndrome protein, is critical for the assembly of cortical actin cytoskeleton

21 January 2018

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Wasp, the Drosophila Wiskott-Aldrich syndrome gene homologue, is required for cell fate decisions mediated by Notch signaling

21 January 2018

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X-linked thrombocytopenia and Wiskott-Aldrich syndrome are allelic diseases with mutations in the WASP gene

21 January 2018

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Doing (F/L)PPPPs: EVH1 domains and their proline-rich partners in cell polarity and migration

21 January 2018

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Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate

21 January 2018

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Activation by Cdc42 and PIP(2) of Wiskott-Aldrich syndrome protein (WASp) stimulates actin nucleation by Arp2/3 complex

21 January 2018

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WIP, a protein associated with wiskott-aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells

21 January 2018

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WIP regulates N-WASP-mediated actin polymerization and filopodium formation

21 January 2018

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Ras and Rho GTPases: a family reunion

21 January 2018

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21 January 2018

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Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

21 January 2018

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The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

21 January 2018

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Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade

21 January 2018

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Interplay between Rac and Rho in the control of substrate contact dynamics

21 January 2018

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Analysis of thymocyte development reveals that the GTPase RhoA is a positive regulator of T cell receptor responses in vivo

21 January 2018

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Rho proteins: linking signaling with membrane trafficking

21 January 2018

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The gamma-subunit of the coatomer complex binds Cdc42 to mediate transformation

21 January 2018

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Effectors for the Rho GTPases

21 January 2018

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Rho GTPases and their effector proteins

21 January 2018

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The Cdc42/Rac interactive binding region motif of the Wiskott Aldrich syndrome protein (WASP) is necessary but not sufficient for tight binding to Cdc42 and structure formation

21 January 2018

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IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling

21 January 2018

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Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex

21 January 2018

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Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein

21 January 2018

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The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly

21 January 2018

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GRB2 links signaling to actin assembly by enhancing interaction of neural Wiskott-Aldrich syndrome protein (N-WASp) with actin-related protein (ARP2/3) complex

21 January 2018

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Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway

21 January 2018

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Activation of the CDC42 effector N-WASP by the Shigella flexneri IcsA protein promotes actin nucleation by Arp2/3 complex and bacterial actin-based motility

21 January 2018

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PIP2 and PIP3: complex roles at the cell surface

21 January 2018

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Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex

21 January 2018

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The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly

21 January 2018

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The Arp2/3 complex: a multifunctional actin organizer

21 January 2018

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Structure and function of the Arp2/3 complex

21 January 2018

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The Arp2/3 complex nucleates actin filament branches from the sides of pre-existing filaments

21 January 2018

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Structure of Arp2/3 complex in its activated state and in actin filament branch junctions

21 January 2018

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The interaction of Arp2/3 complex with actin: nucleation, high affinity pointed end capping, and formation of branching networks of filaments

21 January 2018

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Direct observation of dendritic actin filament networks nucleated by Arp2/3 complex and WASP/Scar proteins.

21 January 2018

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Actin polymerization is induced by Arp2/3 protein complex at the surface of Listeria monocytogenes

21 January 2018

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Interaction of human Arp2/3 complex and the Listeria monocytogenes ActA protein in actin filament nucleation

21 January 2018

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Reconstitution of actin-based motility of Listeria and Shigella using pure proteins

21 January 2018

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N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility

21 January 2018

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Neural Wiskott-Aldrich syndrome protein is implicated in the actin-based motility of Shigella flexneri

21 January 2018

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A complex of N-WASP and WIP integrates signalling cascades that lead to actin polymerization

21 January 2018

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Enteropathogenic E. coli acts through WASP and Arp2/3 complex to form actin pedestals

21 January 2018

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Enteropathogenic E. coli Tir binds Nck to initiate actin pedestal formation in host cells

21 January 2018

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Actin-based motility of vaccinia virus

21 January 2018

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Kinesin-dependent movement on microtubules precedes actin-based motility of vaccinia virus

21 January 2018

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Actin pedestal formation by enteropathogenic Escherichia coli and intracellular motility of Shigella flexneri are abolished in N-WASP-defective cells

21 January 2018

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Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex

21 January 2018

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Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP

21 January 2018

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Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch

21 January 2018

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Profilin enhances Cdc42-induced nucleation of actin polymerization

21 January 2018

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A WASp-VASP complex regulates actin polymerization at the plasma membrane.

21 January 2018

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PSTPIP is a substrate of PTP-PEST and serves as a scaffold guiding PTP-PEST toward a specific dephosphorylation of WASP

21 January 2018

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Interaction between Wiskott-Aldrich Syndrome protein (WASP) and the Fyn protein-tyrosine kinase

21 January 2018

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Three-dimensional segregation of supramolecular activation clusters in T cells

21 January 2018

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Signaling takes shape in the immune system

21 January 2018

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T cell activation and the cytoskeleton

21 January 2018

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21 January 2018

FERMing up the synapse.

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Vav1/Rac-dependent actin cytoskeleton reorganization is required for lipid raft clustering in T cells

21 January 2018

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The immunological synapse of CTL contains a secretory domain and membrane bridges.

21 January 2018

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T cell receptor signaling precedes immunological synapse formation

21 January 2018

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Evidence for defective transmembrane signaling in B cells from patients with Wiskott-Aldrich syndrome

21 January 2018

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Wasp recruitment to the T cell:APC contact site occurs independently of Cdc42 activation

21 January 2018

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Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation.

21 January 2018

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Antigen receptor-induced activation and cytoskeletal rearrangement are impaired in Wiskott-Aldrich syndrome protein-deficient lymphocytes

21 January 2018

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WASp verprolin homology, cofilin homology, and acidic region domain-mediated actin polymerization is required for T cell development

21 January 2018

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Overexpression of the Wiskott-Aldrich syndrome protein N-terminal domain in transgenic mice inhibits T cell proliferative responses via TCR signaling without affecting cytoskeletal rearrangements

21 January 2018

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Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton

21 January 2018

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Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor

21 January 2018

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Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction

21 January 2018

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A novel functional interaction between Vav and PKCtheta is required for TCR-induced T cell activation.

21 January 2018

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Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells

21 January 2018

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The intersectin 2 adaptor links Wiskott Aldrich Syndrome protein (WASp)-mediated actin polymerization to T cell antigen receptor endocytosis

21 January 2018

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Defective actin polymerization in EBV-transformed B-cell lines from patients with the Wiskott-Aldrich syndrome

21 January 2018

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Absence of marginal zone B cells in Pyk-2-deficient mice defines their role in the humoral response

21 January 2018

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Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigens

21 January 2018

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The spleen in the Wiskott-Aldrich syndrome: histopathologic abnormalities of the white pulp correlate with the clinical phenotype of the disease.

21 January 2018

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WIP deficiency reveals a differential role for WIP and the actin cytoskeleton in T and B cell activation

21 January 2018

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A role for Cdc42 in macrophage chemotaxis

21 January 2018

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Chemotaxis of macrophages is abolished in the Wiskott-Aldrich syndrome.

21 January 2018

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Configuration of human dendritic cell cytoskeleton by Rho GTPases, the WAS protein, and differentiation

21 January 2018

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The polarization defect of Wiskott-Aldrich syndrome macrophages is linked to dislocalization of the Arp2/3 complex.

21 January 2018

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Cytoskeletal and adhesive structural polarizations accompany IL-13-induced human macrophage fusion

21 January 2018

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Integrating the actin and vimentin cytoskeletons. adhesion-dependent formation of fimbrin-vimentin complexes in macrophages

21 January 2018

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Cell-substratum interaction of cultured avian osteoclasts is mediated by specific adhesion structures

21 January 2018

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Kinetics of the osteoclast cytoskeleton during the resorption cycle in vitro.

21 January 2018

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Clear zone in osteoclast function: role of podosomes in regulation of bone-resorbing activity

21 January 2018

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The interaction between Cdc42 and WASP is required for SDF-1-induced T-lymphocyte chemotaxis.

21 January 2018

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The embryonic origins of human haematopoiesis

21 January 2018

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Function of Rho family proteins in actin dynamics during phagocytosis and engulfment

21 January 2018

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Fc receptor-mediated phagocytosis requires CDC42 and Rac1.

21 January 2018

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Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPases

21 January 2018

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Requirements for both Rac1 and Cdc42 in membrane ruffling and phagocytosis in leukocytes

21 January 2018

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Involvement of the Arp2/3 complex in phagocytosis mediated by FcgammaR or CR3.

21 January 2018

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Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies

21 January 2018

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Cutting edge: the Wiskott-Aldrich syndrome protein is required for efficient phagocytosis of apoptotic cells

21 January 2018

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Developmental control of endocytosis in dendritic cells by Cdc42.

21 January 2018

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Rac is required for constitutive macropinocytosis by dendritic cells but does not control its downregulation.

21 January 2018

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Spontaneous in vivo reversion of an inherited mutation in the Wiskott-Aldrich syndrome

21 January 2018

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Somatic mosaicism in Wiskott--Aldrich syndrome suggests in vivo reversion by a DNA slippage mechanism.

21 January 2018

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Missense mutations of the WASP gene cause intermittent X-linked thrombocytopenia

21 January 2018

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Constitutively activating mutation in WASP causes X-linked severe congenital neutropenia

21 January 2018

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Characterization of TCL, a new GTPase of the rho family related to TC10 andCcdc42

21 January 2018

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Distinct cellular effects and interactions of the Rho-family GTPase TC10.

21 January 2018

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Wiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domains

21 January 2018

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Wiskott-Aldrich syndrome protein is associated with the adapter protein Grb2 and the epidermal growth factor receptor in living cells

21 January 2018

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Wiskott-Aldrich syndrome protein (WASp) is a binding partner for c-Src family protein-tyrosine kinases

21 January 2018

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Tyrosine phosphorylation regulates the SH3-mediated binding of the Wiskott-Aldrich syndrome protein to PSTPIP, a cytoskeletal-associated protein

21 January 2018

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The essential role of profilin in the assembly of actin for microspike formation

21 January 2018

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Cdc42-interacting protein 4 mediates binding of the Wiskott-Aldrich syndrome protein to microtubules

21 January 2018

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Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex

21 January 2018

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Cdc42 is required for PIP(2)-induced actin polymerization and early development but not for cell viability

21 January 2018

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N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases

21 January 2018

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Rho GTPases and their effector proteins

31 March 2020

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Tyrosine phosphorylation of the Wiskott-Aldrich syndrome protein by Lyn and Btk is regulated by CDC42

31 March 2020

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Cdc42, Rac1, and the Wiskott-Aldrich syndrome protein are involved in the cytoskeletal regulation of B lymphocytes

31 March 2020

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Intrinsic dendritic cell abnormalities in Wiskott-Aldrich syndrome

31 March 2020

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Adhesion patterns and cytoskeleton of rabbit osteoclasts on bone slices and glass

31 March 2020

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Immunocytochemical distribution of extracellular matrix receptors in human osteoclasts: A β3 integrin is colocalized with vinculin and talin in the podosomes of osteoclastoma giant cells

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI884

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4 August 2017

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PubMed ID

12209132