(Q34811630)

4 August 2017

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title

Probes for the dopamine transporter: new leads toward a cocaine-abuse therapeutic--A focus on analogues of benztropine and rimcazole (English)

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4 August 2017

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1

Amy Hauck Newman

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4 August 2017

Santosh Kulkarni

2

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4 August 2017

publication date

1 September 2002

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Medicinal Research Reviews

4 August 2017

published in

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4 August 2017

volume

22

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4 August 2017

issue

5

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4 August 2017

page(s)

429-464

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Cocaine medications, cocaine consumption and societal costs

4 August 2017

cites work

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Molecular basis of long-term plasticity underlying addiction

21 January 2018

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Addiction, dopamine, and the molecular mechanisms of memory

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Could a common biochemical mechanism underlie addictions?

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Addictive Drugs and Brain Stimulation Reward

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Molecular Mechanisms of Drug Reinforcement and Addiction

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Cocaine receptors on dopamine transporters are related to self-administration of cocaine

21 January 2018

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The dopamine hypothesis of the reinforcing properties of cocaine

21 January 2018

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Molecular and regional targets of cocaine in primate brain: liberation from prosaic views

21 January 2018

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The dopamine hypothesis of reward: past and current status

21 January 2018

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Neurotransmitter transporters as molecular targets for addictive drugs.

21 January 2018

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Relationship between subjective effects of cocaine and dopamine transporter occupancy

21 January 2018

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Structure and function of the dopamine transporter

21 January 2018

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Cloning and expression of a cocaine-sensitive dopamine transporter complementary DNA.

21 January 2018

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Cloning and functional characterization of a cocaine-sensitive dopamine transporter

21 January 2018

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Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter

21 January 2018

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Cocaine self-administration in dopamine-transporter knockout mice

21 January 2018

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Cocaine reward models: conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice

21 January 2018

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Molecular mechanisms of cocaine reward: combined dopamine and serotonin transporter knockouts eliminate cocaine place preference

21 January 2018

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Dopaminergic agents for the treatment of cocaine abuse

21 January 2018

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Pharmacotherapies for treatment of cocaine abuse: preclinical aspects

21 January 2018

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Novel 3 alpha-(diphenylmethoxy)tropane analogs: potent dopamine uptake inhibitors without cocaine-like behavioral profiles.

21 January 2018

1 reference

Novel 4'-substituted and 4',4"-disubstituted 3 alpha-(diphenylmethoxy)tropane analogs as potent and selective dopamine uptake inhibitors

21 January 2018

1 reference

3'-Chloro-3 alpha-(diphenylmethoxy)tropane but not 4'-chloro-3 alpha-(diphenylmethoxy)tropane produces a cocaine-like behavioral profile

21 January 2018

1 reference

Novel N-substituted 3 alpha-[bis(4'-fluorophenyl)methoxy]tropane analogues: selective ligands for the dopamine transporter

21 January 2018

1 reference

Isothiocyanate derivatives of 9-[3-(cis-3,5-dimethyl-1-piperazinyl)propyl]carbazole (rimcazole): irreversible ligands for the dopamine transporter

21 January 2018

1 reference

Structure-activity relationships at the monoamine transporters and sigma receptors for a novel series of 9-[3-(cis-3, 5-dimethyl-1-piperazinyl)propyl]carbazole (rimcazole) analogues

21 January 2018

1 reference

CoMFA study of novel phenyl ring-substituted 3alpha-(diphenylmethoxy)tropane analogues at the dopamine transporter

21 January 2018

1 reference

Structure-activity relationships at monoamine transporters and muscarinic receptors for N-substituted-3alpha-(3'-chloro-, 4'-chloro-, and 4',4''-dichloro-substituted-diphenyl)methoxytropanes

21 January 2018

1 reference

[3-cis-3,5-Dimethyl-(1-piperazinyl)alkyl]-bis-(4'-fluorophenyl)amine analogues as novel probes for the dopamine transporter

21 January 2018

1 reference

Dopamine transporter ligand binding domains. Structural and functional properties revealed by limited proteolysis

21 January 2018

1 reference

The uptake inhibitors cocaine and benztropine differentially alter the conformation of the human dopamine transporter

21 January 2018

1 reference

The discovery of an unusually selective and novel cocaine analog: difluoropine. Synthesis and inhibition of binding at cocaine recognition sites

21 January 2018

1 reference

Enantioselective synthesis of S-(+)-2beta-carboalkoxy-3alpha-[bis(4-fluorophenyl)methoxy]tropanes as novel probes for the dopamine transporter

21 January 2018

1 reference

2-Carbomethoxy-3-(diarylmethoxy)-1 alpha H, 5 alpha H-tropane analogs: synthesis and inhibition of binding at the dopamine transporter and comparison with piperazines of the GBR series.

21 January 2018

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Effects of two-carbon bridge region methoxylation of benztropine: discovery of novel chiral ligands for the dopamine transporter

21 January 2018

1 reference

Potent substituted-3β-phenyltropane analogs of cocaine have cocaine-like discriminative stimulus effects

21 January 2018

1 reference

Measuring reward with the conditioned place preference paradigm: a comprehensive review of drug effects, recent progress and new issues

21 January 2018

1 reference

Self-administration of cocaine analogs by rats.

21 January 2018

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Relations between heterogeneity of dopamine transporter binding and function and the behavioral pharmacology of cocaine

21 January 2018

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Dopamine transporter binding without cocaine-like behavioral effects: synthesis and evaluation of benztropine analogs alone and in combination with cocaine in rodents

21 January 2018

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3'- and 4'-chloro-substituted analogs of benztropine: intravenous self-administration and in vitro radioligand binding studies in rhesus monkeys.

21 January 2018

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Further studies of the reinforcing effects of benztropine analogs in rhesus monkeys

21 January 2018

1 reference

Cocaine receptor: biochemical characterization and structure-activity relationships of cocaine analogues at the dopamine transporter

21 January 2018

1 reference

Compounds Affecting the Central Nervous System. 4. 3.beta.-Phenyltropane-2-carboxylic Esters and Analogs

21 January 2018

1 reference

2.beta.-Substituted analogs of cocaine. Synthesis and inhibition of binding to the cocaine receptor

21 January 2018

1 reference

Isopropyl and phenyl esters of 3 beta-(4-substituted phenyl)tropan-2 beta-carboxylic acids. Potent and selective compounds for the dopamine transporter.

21 January 2018

1 reference

Cocaine and 3 beta-(4'-substituted phenyl)tropane-2 beta-carboxylic acid ester and amide analogues. New high-affinity and selective compounds for the dopamine transporter

21 January 2018

1 reference

Synthesis of 2 beta-acyl-3 beta-aryl-8-azabicyclo[3.2.1]octanes and their binding affinities at dopamine and serotonin transport sites in rat striatum and frontal cortex

21 January 2018

1 reference

Synthesis, dopamine transporter affinity, dopamine uptake inhibition, and locomotor stimulant activity of 2-substituted 3 beta-phenyltropane derivatives

21 January 2018

1 reference

Structure-activity relationship studies of cocaine: replacement of the C-2 ester group by vinyl argues against H-bonding and provides an esterase-resistant, high-affinity cocaine analogue

21 January 2018

1 reference

Chemistry and Biology of the 2.beta.-Alkyl-3.beta.-phenyl Analogs of Cocaine: Subnanomolar Affinity Ligands That Suggest a New Pharmacophore Model at the C-2 Position

21 January 2018

1 reference

Novel 2-substituted cocaine analogs: binding properties at dopamine transport sites in rat striatum

21 January 2018

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Enantioselectivity of cocaine recognition sites: binding of (1S)- and (1R)-2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane (beta-CIT) to monoamine transporters.

21 January 2018

1 reference

Extracellular dopamine in rat striatum following uptake inhibition by cocaine, nomifensine and benztropine.

21 January 2018

1 reference

Synthesis, ligand binding, and quantitative structure-activity relationship study of 3 beta-(4'-substituted phenyl)-2 beta-heterocyclic tropanes: evidence for an electrostatic interaction at the 2 beta-position.

21 January 2018

1 reference

Synthesis, ligand binding, QSAR, and CoMFA study of 3 beta-(p-substituted phenyl)tropane-2 beta-carboxylic acid methyl esters

21 January 2018

1 reference

Synthesis, ligand binding, and QSAR (CoMFA and classical) study of 3 beta-(3'-substituted phenyl)-, 3 beta-(4'-substituted phenyl)-, and 3 beta-(3',4'-disubstituted phenyl)tropane-2 beta-carboxylic acid methyl esters

21 January 2018

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2'-Substitution of cocaine selectively enhances dopamine and norepinephrine transporter binding

21 January 2018

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Synthesis of 6- and 7- hydroxy-8-azabicyclo[3.2.1]octanes and their binding affinity for the dopamine and serotonin transporters

21 January 2018

1 reference

Synthesis of 2beta-acyl-3beta-(substituted naphthyl)-8-azabicyclo[3.2.1]octanes and their binding affinities at dopamine and serotonin transport sites.

21 January 2018

1 reference

(-)-3 beta-Substituted ecgonine methyl esters as inhibitors for cocaine binding and dopamine uptake

21 January 2018

1 reference

Methoxylation of cocaine reduces binding affinity and produces compounds of differential binding and dopamine uptake inhibitory activity: discovery of a weak cocaine "antagonist".

21 January 2018

1 reference

Synthesis, structure, dopamine transporter affinity, and dopamine uptake inhibition of 6-alkyl-3-benzyl-2-[(methoxycarbonyl)methyl]tropane derivatives

21 January 2018

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Chemical synthesis and pharmacology of 6- and 7-hydroxylated 2-carbomethoxy-3-(p-tolyl)tropanes: antagonism of cocaine's locomotor stimulant effects.

21 January 2018

1 reference

N-omega-fluoroalkyl analogs of (1R)-2 beta-carbomethoxy-3 beta-(4-iodophenyl)-tropane (beta-CIT): radiotracers for positron emission tomography and single photon emission computed tomography imaging of dopamine transporters.

21 January 2018

1 reference

Structure-activity relationship studies of N-sulfonyl analogs of cocaine: role of ionic interaction in cocaine binding.

21 January 2018

1 reference

Bicyclo[3.2.1]octanes: synthesis and inhibition of binding at the dopamine and serotonin transporters.

21 January 2018

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3-Aryl-2-carbomethoxybicyclo[3.2.1]oct-2-enes inhibit WIN 35,428 binding potently and selectively at the dopamine transporter.

21 January 2018

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Highly potent cocaine analogs cause long-lasting increases in locomotor activity.

21 January 2018

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Separation of the locomotor stimulant and discriminative stimulus effects of cocaine by its C-2 phenyl ester analog, RTI-15.

21 January 2018

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Cocaine binding at sigma receptors.

21 January 2018

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Selective sigma ligands block stimulant effects of cocaine.

21 January 2018

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Involvement of the sigma1 receptor in the cocaine-induced conditioned place preference

21 January 2018

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Two novel sigma receptor ligands, BD1047 and LR172, attenuate cocaine-induced toxicity and locomotor activity

21 January 2018

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Novel sigma receptor ligands attenuate the locomotor stimulatory effects of cocaine

21 January 2018

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Rimcazole analogs attenuate the convulsive effects of cocaine: correlation with binding to sigma receptors rather than dopamine transporters

21 January 2018

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Cocaine and several sigma receptor ligands inhibit dopamine uptake in rat caudate-putamen.

21 January 2018

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Evidence that the potential antipsychotic agent rimcazole (BW 234U) is a specific, competitive antagonist of sigma sites in brain

21 January 2018

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The dopamine inhibitor GBR 12909: selectivity and molecular mechanism of action

21 January 2018

1 reference

Development of novel, potent, and selective dopamine reuptake inhibitors through alteration of the piperazine ring of 1-[2-(diphenylmethoxy)ethyl]-and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909).

21 January 2018

1 reference

Synthesis and transporter binding properties of bridged piperazine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909).

21 January 2018

1 reference

Structure-activity relationship studies of novel 4-[2-[bis(4-fluorophenyl)methoxy]ethyl]-1-(3-phenylpropyl)piperidine analogs: synthesis and biological evaluation at the dopamine and serotonin transporter sites.

21 January 2018

1 reference

Rational design and synthesis of novel 2,5-disubstituted cis- and trans-piperidine derivatives exhibiting differential activity for the dopamine transporter

21 January 2018

1 reference

Highly selective, novel analogs of 4-[2-(diphenylmethoxy)ethyl]- 1-benzylpiperidine for the dopamine transporter: effect of different aromatic substitutions on their affinity and selectivity

21 January 2018

1 reference

Design, synthesis, and biological evaluation of novel non-piperazine analogues of 1-[2-(diphenylmethoxy)ethyl]- and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines as dopamine transporter inhibitors

21 January 2018

1 reference

Novel 3-aminomethyl- and 4-aminopiperidine analogues of 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazines: synthesis and evaluation as dopamine transporter ligands

21 January 2018

1 reference

Heteroaromatic analogs of 1-[2-(diphenylmethoxy)ethyl]- and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909) as high-affinity dopamine reuptake inhibitors.

21 January 2018

1 reference

Potent and selective ligands for the dopamine transporter (DAT): structure-activity relationship studies of novel 4-[2-(diphenylmethoxy)ethyl]-1-(3-phenylpropyl)piperidine analogues

21 January 2018

1 reference

Oxygenated analogues of 1-[2-(Diphenylmethoxy)ethyl]- and 1-[2-[Bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909) as potential extended-action cocaine-abuse therapeutic agents

21 January 2018

1 reference

Tolerance in the replacement of the benzhydrylic O atom in 4-[2-(diphenylmethoxy)ethyl]-1-benzylpiperidine derivatives by an N atom: development of new-generation potent and selective N-analogue molecules for the dopamine transporter

21 January 2018

1 reference

Structure-activity relationship studies of 4-[2-(diphenylmethoxy)ethyl]-1-benzylpiperidine derivatives and their N-analogues: evaluation of O-and N-analogues and their binding to monoamine transporters

21 January 2018

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Synthesis and biological evaluation of tropane-like 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909) analogues

21 January 2018

1 reference

A review of the effects of dopaminergic agents on humans, animals, and drug-seeking behavior, and its implications for medication development. Focus on GBR 12909.

21 January 2018

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Effects of GBR 12909, a selective dopamine uptake inhibitor, on motor activity and operant behavior in the rat.

21 January 2018

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Effects of GBR 12909 and cocaine on cocaine-maintained behavior in rhesus monkeys.

21 January 2018

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Self-administration of GBR 12909 on a fixed ratio and progressive ratio schedule in rats.

21 January 2018

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Doses of GBR12909 that suppress cocaine self-administration in non-human primates substantially occupy dopamine transporters as measured by [11C] WIN35,428 PET scans.

21 January 2018

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Sustained decrease in cocaine-maintained responding in rhesus monkeys with 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-hydroxy-3-phenylpropyl) piperazinyl decanoate, a long-acting ester derivative of GBR 12909.

21 January 2018

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Sodium-sensitive cocaine binding to rat striatal membrane: possible relationship to dopamine uptake sites

21 January 2018

1 reference

[3H]MFZ 2-12: a novel radioligand for the dopamine transporter.

21 January 2018

1 reference

Chimeric dopamine-norepinephrine transporters delineate structural domains influencing selectivity for catecholamines and 1-methyl-4-phenylpyridinium

21 January 2018

1 reference

A putative model of the dopamine transporter.

21 January 2018

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Cloning and expression of a cocaine-sensitive rat dopamine transporter

21 January 2018

1 reference

Cloning of the cocaine-sensitive bovine dopamine transporter

21 January 2018

1 reference

Molecular cloning and functional expression of the mouse dopamine transporter

21 January 2018

1 reference

Cloning of dopamine, norepinephrine and serotonin transporters from monkey brain: relevance to cocaine sensitivity.

21 January 2018

1 reference

Dopamine transporter site-directed mutations differentially alter substrate transport and cocaine binding

21 January 2018

1 reference

Defining proximity relationships in the tertiary structure of the dopamine transporter. Identification of a conserved glutamic acid as a third coordinate in the endogenous Zn(2+)-binding site.

21 January 2018

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Nitrogen-based drugs are not essential for blockade of monoamine transporters

21 January 2018

1 reference

Novel tropane-based irreversible ligands for the dopamine transporter

21 January 2018

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Cocaine alters the accessibility of endogenous cysteines in putative extracellular and intracellular loops of the human dopamine transporter.

21 January 2018

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Symmetrical dimer of the human dopamine transporter revealed by cross-linking Cys-306 at the extracellular end of the sixth transmembrane segment

21 January 2018

1 reference

Analysis of cocaine receptor site ligand binding by three-dimensional Voronoi site modeling approach.

21 January 2018

1 reference

2D QSAR modeling and preliminary database searching for dopamine transporter inhibitors using genetic algorithm variable selection of Molconn Z descriptors.

21 January 2018

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21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/MED.10014

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4 August 2017

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