(Q34840130)

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Bridging the clinical gaps: genetic, epigenetic and transcriptomic biomarkers for the early detection of lung cancer in the post-National Lung Screening Trial era

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scholarly article

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Europe PubMed Central

4 August 2017

1 reference

7 April 2021

Bridging the clinical gaps: genetic, epigenetic and transcriptomic biomarkers for the early detection of lung cancer in the post-National Lung Screening Trial era (English)

1 reference

Europe PubMed Central

4 August 2017

1 reference

based on heuristic

inferred from abstract

transcriptomics

1 reference

based on heuristic

inferred from abstract

1 reference

7 April 2021

genetic epigenesis

1 reference

25 September 2020

1 reference

23 December 2020

gene expression profiling

1 reference

7 April 2021

1 reference

based on heuristic

inferred from title

object named as

Avrum Spira

6

0 references

author name string

John F Brothers

1

1 reference

Europe PubMed Central

4 August 2017

Kahkeshan Hijazi

2

1 reference

Europe PubMed Central

4 August 2017

Celine Mascaux

3

1 reference

Europe PubMed Central

4 August 2017

Randa A El-Zein

4

1 reference

Europe PubMed Central

4 August 2017

Margaret R Spitz

5

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Europe PubMed Central

4 August 2017

language of work or name

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publication date

19 July 2013

9 references

Europe PubMed Central

4 August 2017

3 April 2019

20 June 2019

22 July 2019

8 September 2019

19 September 2019

25 September 2020

23 December 2020

7 April 2021

9 references

Europe PubMed Central

4 August 2017

3 April 2019

20 June 2019

22 July 2019

8 September 2019

19 September 2019

25 September 2020

23 December 2020

7 April 2021

11

1 reference

Europe PubMed Central

4 August 2017

168

1 reference

Europe PubMed Central

4 August 2017

copyright license

Creative Commons Attribution 2.0 Generic

8 references

Europe PubMed Central

3 April 2019

Europe PubMed Central

20 June 2019

Europe PubMed Central

22 July 2019

Europe PubMed Central

8 September 2019

Europe PubMed Central

19 September 2019

Europe PubMed Central

25 September 2020

Europe PubMed Central

23 December 2020

Europe PubMed Central

7 April 2021

copyright status

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on focus list of Wikimedia project

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https://scigraph.springernature.com/pub.10.1186/1741-7015-11-168

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Utility of serum DNA and pyrosequencing for the detection of EGFR mutations in non-small cell lung cancer.

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Analysis of circulating tumor DNA to monitor metastatic breast cancer

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Role of selected genetic variants in lung cancer risk in African Americans

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Genetic variants at 6p21.1 and 7p15.3 are associated with risk of multiple cancers in Han Chinese

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MicroRNA expression profiles of whole blood in lung adenocarcinoma

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Association analyses identify multiple new lung cancer susceptibility loci and their interactions with smoking in the Chinese population

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A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population

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The state of molecular biomarkers for the early detection of lung cancer

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Inherited variation at chromosome 12p13.33, including RAD52, influences the risk of squamous cell lung carcinoma

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Defining a gene promoter methylation signature in sputum for lung cancer risk assessment

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Genetic predisposition to chronic obstructive pulmonary disease and/or lung cancer: important considerations when evaluating risk

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A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13.

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CpG site-specific hypermethylation of p16INK4α in peripheral blood lymphocytes of PAH-exposed workers

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A serum circulating miRNA diagnostic test to identify asymptomatic high-risk individuals with early stage lung cancer

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A gene expression signature from peripheral whole blood for stage I lung adenocarcinoma

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A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese

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Reduced lung-cancer mortality with low-dose computed tomographic screening

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Recent advances in gene manipulation and nicotinic acetylcholine receptor biology.

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Characterizing the impact of smoking and lung cancer on the airway transcriptome using RNA-Seq

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An epigenetic marker panel for detection of lung cancer using cell-free serum DNA.

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Lung cancer risk prediction: Prostate, Lung, Colorectal And Ovarian Cancer Screening Trial models and validation.

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Chromosome 15q25 (CHRNA3-CHRNA5) variation impacts indirectly on lung cancer risk

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8 July 2018

Aberrant expression of let-7a miRNA in the blood of non-small cell lung cancer patients

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8 July 2018

Reward, addiction, withdrawal to nicotine

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Screening for circulating nucleic acids and caspase activity in the peripheral blood as potential diagnostic tools in lung cancer

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Early detection of lung adenocarcinoma in sputum by a panel of microRNA markers

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Individual and cumulative effects of GWAS susceptibility loci in lung cancer: associations after sub-phenotyping for COPD

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8 July 2018

MicroRNA signatures in tissues and plasma predict development and prognosis of computed tomography detected lung cancer

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Global cancer statistics

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Plasma microRNAs as potential biomarkers for non-small-cell lung cancer

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Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD.

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Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer

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Global patterns of cancer incidence and mortality rates and trends

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8 July 2018

Mediating effects of smoking and chronic obstructive pulmonary disease on the relation between the CHRNA5-A3 genetic locus and lung cancer risk

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Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer Consortium

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8 July 2018

Early detection of squamous cell lung cancer in sputum by a panel of microRNA markers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717087

8 July 2018

Methylation markers for small cell lung cancer in peripheral blood leukocyte DNA.

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8 July 2018

Genome-wide meta-analyses identify multiple loci associated with smoking behavior

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8 July 2018

Meta-analysis and imputation refines the association of 15q25 with smoking quantity

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8 July 2018

Airway PI3K pathway activation is an early and reversible event in lung cancer development

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8 July 2018

Effects of cigarette smoke on the human oral mucosal transcriptome

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8 July 2018

Real-time PCR quantification of plasma DNA in non-small cell lung cancer patients and healthy controls

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8 July 2018

Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function

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8 July 2018

Genome-wide association study identifies five loci associated with lung function

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8 July 2018

Value of quantitative analysis of circulating cell free DNA as a screening tool for lung cancer: a meta-analysis

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8 July 2018

Similarities and differences between smoking-related gene expression in nasal and bronchial epithelium

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8 July 2018

Gene expression profiles in peripheral blood mononuclear cells can distinguish patients with non-small cell lung cancer from patients with nonmalignant lung disease

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8 July 2018

Nicotine dependence may link the 15q25 locus to lung cancer risk.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717087

8 July 2018

Pattern of antioxidant and DNA repair gene expression in normal airway epithelium associated with lung cancer diagnosis

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8 July 2018

A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma

1 reference

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8 July 2018

miRNAs in lung cancer - studying complex fingerprints in patient's blood cells by microarray experiments

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8 July 2018

Haplotype and cell proliferation analyses of candidate lung cancer susceptibility genes on chromosome 15q24-25.1.

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8 July 2018

Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study

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8 July 2018

Altered miRNA expression in sputum for diagnosis of non-small cell lung cancer

1 reference

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8 July 2018

Current smoking-specific gene expression signature in normal bronchial epithelium is enhanced in squamous cell lung cancer

1 reference

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8 July 2018

Comparison of circulating plasma DNA levels between lung cancer patients and healthy controls

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8 July 2018

A genome-wide association study of pulmonary function measures in the Framingham Heart Study

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8 July 2018

A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci.

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8 July 2018

Exosomal microRNA: a diagnostic marker for lung cancer

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8 July 2018

A prediction model for lung cancer diagnosis that integrates genomic and clinical features

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8 July 2018

Evolution of microRNA expression during human bronchial squamous carcinogenesis

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8 July 2018

Common 5p15.33 and 6p21.33 variants influence lung cancer risk

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8 July 2018

The CHRNA5-A3 region on chromosome 15q24-25.1 is a risk factor both for nicotine dependence and for lung cancer

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8 July 2018

Circulating plasma DNA as diagnostic biomarker in non-small cell lung cancer

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8 July 2018

Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases

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8 July 2018

Perspectives for improved and more accurate classification of thyroid epithelial tumors

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8 July 2018

Smoking-induced gene expression changes in the bronchial airway are reflected in nasal and buccal epithelium

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8 July 2018

A variant associated with nicotine dependence, lung cancer and peripheral arterial disease

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8 July 2018

A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25

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8 July 2018

Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1

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8 July 2018

microRNAs: small molecules with big roles - C. elegans to human cancer

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8 July 2018

The LLP risk model: an individual risk prediction model for lung cancer

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8 July 2018

Framingham Heart Study genome-wide association: results for pulmonary function measures

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8 July 2018

Perceptions of epigenetics

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8 July 2018

Lung cancer: diagnosis and management.

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8 July 2018

A genome-wide screen for promoter methylation in lung cancer identifies novel methylation markers for multiple malignancies

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8 July 2018

Amplification of telomerase (hTERT) gene is a poor prognostic marker in non-small-cell lung cancer

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8 July 2018

DNA methylation and human disease

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8 July 2018

Methylation discriminators in NSCLC identified by a microarray based approach

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8 July 2018

Lung cancer in US women: a contemporary epidemic

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8 July 2018

Quantification of free circulating DNA as a diagnostic marker in lung cancer

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8 July 2018

Variations in lung cancer risk among smokers.

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8 July 2018

DNA methylation patterns and epigenetic memory

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717087

8 July 2018

Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717087

8 July 2018

Isolation and characterization of DNA from the plasma of cancer patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717087

8 July 2018

Free DNA in the serum of cancer patients and the effect of therapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717087

28 July 2018

Cotinine conundrum--a step forward but questions remain

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-11-168

21 January 2018

hTERT cancer risk genotypes are associated with telomere length.

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-11-168

21 January 2018

Replication of results of genome-wide association studies on lung cancer susceptibility loci in a Korean population.

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-11-168

21 January 2018

Gene promoter methylation in plasma and sputum increases with lung cancer risk.

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-11-168

21 January 2018

In vitro induction of myeloid leukemia-specific CD4 and CD8 T cells by CD40 ligand-activated B cells gene modified to express primary granule proteins

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-11-168

21 January 2018

p16INK4A and CDH13 hypermethylation in tumor and serum of non-small cell lung cancer patients.

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-11-168

21 January 2018

Differential DNA hypermethylation of critical genes mediates the stage-specific tobacco smoke-induced neoplastic progression of lung cancer

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-11-168

21 January 2018

Smoking and cancer-related gene expression in bronchial epithelium and non-small-cell lung cancers.

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-11-168

21 January 2018

Blood-based gene expression signatures in non-small cell lung cancer.

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-11-168

21 January 2018

Plasma DNA quantification in lung cancer computed tomography screening: five-year results of a prospective study.

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-11-168

21 January 2018

Efficacy of circulating plasma DNA as a diagnostic tool for advanced non-small cell lung cancer and its predictive utility for survival and response to chemotherapy.

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-11-168

21 January 2018

Application of a highly sensitive detection system for epidermal growth factor receptor mutations in plasma DNA.

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-11-168

21 January 2018

Lung Cancer Risk Prediction to Select Smokers for Screening CT--a Model Based on the Italian COSMOS Trial

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-11-168

21 January 2018

Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717087

26 October 2018

https://api.crossref.org/works/10.1186%2F1741-7015-11-168

21 January 2018

Identification of epigenetic aberrant promoter methylation in serum DNA is useful for early detection of lung cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717087

26 October 2018

Quantification of plasma DNA as a screening tool for lung cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717087

26 October 2018

Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717087

26 October 2018

Identification of ten serum microRNAs from a genome-wide serum microRNA expression profile as novel noninvasive biomarkers for nonsmall cell lung cancer diagnosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23870182

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical significance of circulating tumor cells and free DNA in non-small cell lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/23870182

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

miR-1254 and miR-574-5p: Serum-Based microRNA Biomarkers for Early-Stage Non-small Cell Lung Cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/23870182

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lung cancer in women

1 reference

https://pubmed.ncbi.nlm.nih.gov/23870182

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Promoter hypermethylation of multiple genes in sputum precedes lung cancer incidence in a high-risk cohort

1 reference

https://pubmed.ncbi.nlm.nih.gov/23870182

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypermethylation of ASC/TMS1 is a sputum marker for late-stage lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/23870182

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A risk model for prediction of lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/23870182

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of promoter hypermethylation in serum samples of cancer patients by methylation-specific polymerase chain reaction for tumour suppressor genes including RUNX3

1 reference

https://pubmed.ncbi.nlm.nih.gov/23870182

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma DNA as a marker of cancerous cell death. Investigations in patients suffering from lung cancer and in nude mice bearing human tumours

1 reference

https://pubmed.ncbi.nlm.nih.gov/23870182

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Predicting lung cancer by detecting aberrant promoter methylation in sputum

1 reference

https://pubmed.ncbi.nlm.nih.gov/23870182

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of circulating tumor DNA in plasma at diagnosis and during follow-up of lung cancer patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/23870182

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specific peripheral miRNA profiles for distinguishing lung cancer from COPD

1 reference

https://pubmed.ncbi.nlm.nih.gov/23870182

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stable serum miRNA profiles as potential tool for non-invasive lung cancer diagnosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23870182

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/1741-7015-11-168

1 reference

Europe PubMed Central

4 August 2017

Dimensions Publication ID

0 references

1 reference

Europe PubMed Central

4 August 2017

1 reference

Europe PubMed Central

4 August 2017

ResearchGate publication ID

0 references

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