(Q34850993)

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Design and synthesis of substituted N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides as positive allosteric modulators of the metabotropic glutamate receptor subtype 5.

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scholarly article

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Europe PubMed Central

PubMed publication ID

4 August 2017

Design and synthesis of substituted N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides as positive allosteric modulators of the metabotropic glutamate receptor subtype 5. (English)

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Amy Hauck Newman

5

object named as

Amy Hauck Newman

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

P. Jeffrey Conn

4

object named as

P Jeffrey Conn

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

author name string

Mu-Fa Zou

1

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Jianjing Cao

2

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Alice L Rodriguez

3

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Europe PubMed Central

PubMed publication ID

4 August 2017

language of work or name

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publication date

28 December 2010

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Europe PubMed Central

PubMed publication ID

4 August 2017

number of pages

5

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based on heuristic

inferred from page(s)

Bioorganic & Medicinal Chemistry Letters

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Europe PubMed Central

PubMed publication ID

4 August 2017

21

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Europe PubMed Central

PubMed publication ID

4 August 2017

9

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

2650-2654

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity

1 reference

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8 July 2018

Mechanism-based approaches to treating fragile X

1 reference

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8 July 2018

Discovery of molecular switches that modulate modes of metabotropic glutamate receptor subtype 5 (mGlu5) pharmacology in vitro and in vivo within a series of functionalized, regioisomeric 2- and 5-(phenylethynyl)pyrimidines

1 reference

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8 July 2018

Structure-activity relationships comparing N-(6-methylpyridin-yl)-substituted aryl amides to 2-methyl-6-(substituted-arylethynyl)pyridines or 2-methyl-4-(substituted-arylethynyl)thiazoles as novel metabotropic glutamate receptor subtype 5 antagonist

1 reference

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8 July 2018

N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors

1 reference

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8 July 2018

Design and synthesis of novel heterobiaryl amides as metabotropic glutamate receptor subtype 5 antagonists

1 reference

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8 July 2018

Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses.

1 reference

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8 July 2018

Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive allosteric modulation of the metabotropic glutamate-5 receptor in rat cortical astrocytes

1 reference

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8 July 2018

The role of group I metabotropic glutamate receptors in schizophrenia

1 reference

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8 July 2018

Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic glutamate receptor subtype 5 antagonists; search for cocaine medications

1 reference

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The ups and downs of addiction: role of metabotropic glutamate receptors

1 reference

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8 July 2018

Allosteric modulation of group III metabotropic glutamate receptor 4: A potential approach to Parkinson's disease treatment

1 reference

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8 July 2018

Mutational Analysis and Molecular Modeling of the Binding Pocket of the Metabotropic Glutamate 5 Receptor Negative Modulator 2-Methyl-6-(phenylethynyl)-pyridine

1 reference

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8 July 2018

The metabotropic glutamate receptors: structure, activation mechanism and pharmacology

1 reference

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8 July 2018

3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081927

8 July 2018

mGlu5 receptors and nociceptive function II. mGlu5 receptors functionally expressed on peripheral sensory neurones mediate inflammatory hyperalgesia.

1 reference

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8 July 2018

Metabotropic glutamate receptor subtype 5 (mGlu5) and nociceptive function. I. Selective blockade of mGlu5 receptors in models of acute, persistent and chronic pain.

1 reference

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8 July 2018

Pharmacology and functions of metabotropic glutamate receptors

1 reference

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8 July 2018

Pharmacological activation of mGlu4 metabotropic glutamate receptors reduces nigrostriatal degeneration in mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081927

26 October 2018

Anxiolytic-like activity of the mGluR5 antagonist MPEP: a comparison with diazepam and buspirone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081927

26 October 2018

The non-competitive antagonists 2-methyl-6-(phenylethynyl)pyridine and 7-hydroxyiminocyclopropan[b]chromen-1a-carboxylic acid ethyl ester interact with overlapping binding pockets in the transmembrane region of group I metabotropic glutamate recepto

1 reference

https://pubmed.ncbi.nlm.nih.gov/21295978

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design and synthesis of noncompetitive metabotropic glutamate receptor subtype 5 antagonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/21295978

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.BMCL.2010.12.110

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

ResearchGate publication ID

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