(Q34855692)

4 August 2017

title

Grape polyphenols inhibit Akt/mammalian target of rapamycin signaling and potentiate the effects of gefitinib in breast cancer (English)

1 reference

4 August 2017

1 reference

1 reference

1 reference

Linette Castillo-Pichardo

series ordinal

1

1 reference

4 August 2017

Suranganie F Dharmawardhane

series ordinal

2

1 reference

4 August 2017

publication date

1 January 2012

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4 August 2017

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4 August 2017

volume

64

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4 August 2017

issue

7

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4 August 2017

page(s)

1058-1069

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Polyphenols: key issues involved in chemoprevention of prostate cancer

4 August 2017

cites work

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8 July 2018

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The combination of gefitinib and RAD001 inhibits growth of HER2 overexpressing breast cancer cells and tumors irrespective of trastuzumab sensitivity

8 July 2018

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8 July 2018

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8 July 2018

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Mammalian target of rapamycin: a central node of complex signaling cascades

8 July 2018

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8 July 2018

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8 July 2018

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Grape seed extract upregulates p21 (Cip1) through redox-mediated activation of ERK1/2 and posttranscriptional regulation leading to cell cycle arrest in colon carcinoma HT29 cells.

8 July 2018

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Effect of adding gefitinib to neoadjuvant chemotherapy in estrogen receptor negative early breast cancer in a randomized phase II trial

8 July 2018

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Gefitinib or placebo in combination with tamoxifen in patients with hormone receptor-positive metastatic breast cancer: a randomized phase II study

8 July 2018

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Resveratrol enhances the anti-tumor activity of the mTOR inhibitor rapamycin in multiple breast cancer cell lines mainly by suppressing rapamycin-induced AKT signaling

8 July 2018

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Pharmacokinetics, oral bioavailability, and metabolic profile of resveratrol and its dimethylether analog, pterostilbene, in rats

8 July 2018

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Isolated and combined action of tamoxifen and metformin in wild-type, tamoxifen-resistant, and estrogen-deprived MCF-7 cells

8 July 2018

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Dietary-feeding of grape seed extract prevents azoxymethane-induced colonic aberrant crypt foci formation in fischer 344 rats.

8 July 2018

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Metformin: a therapeutic opportunity in breast cancer

8 July 2018

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AMP-activated protein kinase: a potential target for the diseases prevention by natural occurring polyphenols

8 July 2018

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Anticancer and cancer chemopreventive potential of grape seed extract and other grape-based products

8 July 2018

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Inhibition of mammary tumor growth and metastases to bone and liver by dietary grape polyphenols

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286176

AMP kinase/cyclooxygenase-2 pathway regulates proliferation and apoptosis of cancer cells treated with quercetin

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286176

Toxicity of targeted therapy in non-small-cell lung cancer management

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286176

AMP-activated protein kinase pathway: a potential therapeutic target in cardiometabolic disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286176

LKB1 and AMP-activated protein kinase control of mTOR signalling and growth

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286176

Grape seed extract inhibits VEGF expression via reducing HIF-1alpha protein expression

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286176

Quercetin-induced ubiquitination and down-regulation of Her-2/neu

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286176

Comparison of delphinidin, quercetin and (-)-epigallocatechin-3-gallate as inhibitors of the EGFR and the ErbB2 receptor phosphorylation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286176

Combined resveratrol, quercetin, and catechin treatment reduces breast tumor growth in a nude mouse model

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286176

Acquired resistance to tyrosine kinase inhibitors during cancer therapy

8 July 2018

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BRMS1 suppresses breast cancer experimental metastasis to multiple organs by inhibiting several steps of the metastatic process

8 July 2018

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Overview of resistance to systemic therapy in patients with breast cancer

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286176

An update of the mechanisms of resistance to EGFR-tyrosine kinase inhibitors in breast cancer: Gefitinib (Iressa) -induced changes in the expression and nucleo-cytoplasmic trafficking of HER-ligands (Review).

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286176

Treatment of human epidermal growth factor receptor 2-overexpressing breast cancer xenografts with multiagent HER-targeted therapy

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286176

The role of the epidermal growth factor receptor in breast cancer

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286176

Chemosensitization and radiosensitization of tumors by plant polyphenols

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286176

Phytoestrogens induce differential estrogen receptor alpha- or Beta-mediated responses in transfected breast cancer cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286176

Resveratrol and estradiol exert disparate effects on cell migration, cell surface actin structures, and focal adhesion assembly in MDA-MB-231 human breast cancer cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286176

Resveratrol and breast cancer risk.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286176

Association between pterostilbene and quercetin inhibits metastatic activity of B16 melanoma

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286176

Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286176

Gefitinib (Iressa, ZD1839): a novel targeted approach for the treatment of solid tumors.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286176

The in vitro effect of gefitinib ('Iressa') alone and in combination with cytotoxic chemotherapy on human solid tumours

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286176

Selective cytotoxicity of a red grape wine flavonoid fraction against MCF-7 cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286176

Inhibition of rat mammary tumorigenesis by concord grape juice constituents.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286176

Relationship between mechanisms, bioavailibility, and preclinical chemopreventive efficacy of resveratrol: a conundrum

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286176

Antioxidative flavonoid quercetin: implication of its intestinal absorption and metabolism

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286176

Inhibition of cancer growth by resveratrol is related to its low bioavailability

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286176

Molecular crosstalk between p70S6k and MAPK cell signaling pathways

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286176

Whole-body optical imaging of green fluorescent protein-expressing tumors and metastases

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286176

Grape seed extract inhibits advanced human prostate tumor growth and angiogenesis and upregulates insulin-like growth factor binding protein-3.

8 July 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2012.716898

Urinary and plasma levels of resveratrol and quercetin in humans, mice, and rats after ingestion of pure compounds and grape juice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2012.716898

A comparison of the anticarcinogenic properties of four red wine polyphenols

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2012.716898

Phase II and tumor pharmacodynamic study of gefitinib in patients with advanced breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2012.716898

Phase II, randomized trial to compare anastrozole combined with gefitinib or placebo in postmenopausal women with hormone receptor-positive metastatic breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2012.716898

The mammalian target of rapamycin pathway as a potential target for cancer chemoprevention

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2012.716898

Inhibition of the PI3K pathway: hope we can believe in?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2012.716898

Quercetin potentiates UVB-Induced c-Fos expression: implications for its use as a chemopreventive agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2012.716898

Resveratrol inhibits cancer cell metabolism by down regulating pyruvate kinase M2 via inhibition of mammalian target of rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2012.716898

Epigallocatechin gallate (EGCG), a major component of green tea, is a dual phosphoinositide-3-kinase/mTOR inhibitor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2012.716898

Effects of long-term treatment with resveratrol and subcutaneous and oral estradiol administration on pituitary function in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2012.716898

Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62/SQSTM1 expression and AMPK activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2012.716898

Assessment of some Australian red wines for price, phenolic content, antioxidant activity, and vintage in relation to functional food prospects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2012.716898

Comparative analysis of the phenolic content of selected Chilean, Canadian and American Merlot red wines

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2012.716898

The effects of gefitinib in tamoxifen-resistant and hormone-insensitive breast cancer: a phase II study.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286176

Inhibitors of phosphatidylinositide 3-kinase: effects on reactive oxygen species and platelet aggregation.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286176

The antiproliferative effect of Quercetin in cancer cells is mediated via inhibition of the PI3K-Akt/PKB pathway.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286176

ZD1839 (Iressa): an orally active inhibitor of epidermal growth factor signaling with potential for cancer therapy.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286176

Distribution of Resveratrol Metabolites in Liver, Adipose Tissue, and Skeletal Muscle in Rats Fed Different Doses of This Polyphenol

26 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23061908

12 December 2020

inferred from PubMed ID database lookup

The flavonoid paradox: conjugation and deconjugation as key steps for the biological activity of flavonoids

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23061908

12 December 2020

inferred from PubMed ID database lookup

Value of post-operative reassessment of estrogen receptor α expression following neoadjuvant chemotherapy with or without gefitinib for estrogen receptor negative breast cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23061908

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1080/01635581.2012.716898

1 reference

release_lbp7th2hxrf7hgw4mky4lbx4lu

4 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/lbp7th2hxrf7hgw4mky4lbx4lu

24 November 2022

mapped directly with Wikidata item

PMC publication ID

4286176

1 reference

4 August 2017

1 reference