(Q34875973)

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Protective T cell immunity in mice following protein-TLR7/8 agonist-conjugate immunization requires aggregation, type I IFN, and multiple DC subsets.

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30 January 2020

Protective T cell immunity in mice following protein-TLR7/8 agonist-conjugate immunization requires aggregation, type I IFN, and multiple DC subsets (English)

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30 January 2020

toll-like receptor

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Björn E Clausen

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30 January 2020

Ronald N. Germain

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Ronald N Germain

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30 January 2020

Wolfgang Kastenmüller

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Wolfgang Kastenmüller

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30 January 2020

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Kathrin Kastenmüller

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30 January 2020

Ulrike Wille-Reece

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30 January 2020

Ross W B Lindsay

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30 January 2020

Lauren R Trager

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30 January 2020

Patricia A Darrah

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30 January 2020

Barbara J Flynn

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30 January 2020

Maria R Becker

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30 January 2020

Mark C Udey

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30 January 2020

Botond Z Igyarto

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30 January 2020

Daniel H Kaplan

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30 January 2020

Robert A Seder

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30 January 2020

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11 April 2011

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30 January 2020

Journal of Clinical Investigation

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30 January 2020

121

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30 January 2020

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30 January 2020

1782-1796

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30 January 2020

TLR8 deficiency leads to autoimmunity in mice

1 reference

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Regulation of immune cell homeostasis by type I interferons

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The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signaling.

1 reference

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8 July 2018

GM-CSF-dependent, CD103+ dermal dendritic cells play a critical role in Th effector cell differentiation after subcutaneous immunization.

1 reference

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8 July 2018

Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8alpha+ conventional dendritic cells

1 reference

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Toll-like receptor 8-mediated activation of murine plasmacytoid dendritic cells by vaccinia viral DNA

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Disentangling the complexity of the skin dendritic cell network.

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Plasmacytoid dendritic cell-derived type I interferon is crucial for the adjuvant activity of Toll-like receptor 7 agonists

1 reference

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CD207+ CD103+ dermal dendritic cells cross-present keratinocyte-derived antigens irrespective of the presence of Langerhans cells

1 reference

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Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant

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8 July 2018

Murine epidermal Langerhans cells and langerin-expressing dermal dendritic cells are unrelated and exhibit distinct functions

1 reference

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Differential roles of migratory and resident DCs in T cell priming after mucosal or skin HSV-1 infection

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New horizons in adjuvants for vaccine development

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8 July 2018

Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells

1 reference

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8 July 2018

Targeting poly(I:C) to the TLR3-independent pathway boosts effector CD8 T cell differentiation through IFN-alpha/beta

1 reference

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Batf3 Deficiency Reveals a Critical Role for CD8 + Dendritic Cells in Cytotoxic T Cell Immunity

1 reference

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8 July 2018

Toll-like receptors activate innate and adaptive immunity by using dendritic cell-intrinsic and -extrinsic mechanisms

1 reference

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8 July 2018

Clearance of influenza virus from the lung depends on migratory langerin+CD11b- but not plasmacytoid dendritic cells

1 reference

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Vaccines: correlates of vaccine-induced immunity

1 reference

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8 July 2018

Selective suicide of cross-presenting CD8+ dendritic cells by cytochrome c injection shows functional heterogeneity within this subset

1 reference

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8 July 2018

The microbial mimic poly IC induces durable and protective CD4+ T cell immunity together with a dendritic cell targeted vaccine

1 reference

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PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation

1 reference

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8 July 2018

Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling

1 reference

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8 July 2018

Identification of a novel population of Langerin+ dendritic cells

1 reference

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8 July 2018

Blood-derived dermal langerin+ dendritic cells survey the skin in the steady state

1 reference

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8 July 2018

The dermis contains langerin+ dendritic cells that develop and function independently of epidermal Langerhans cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083762

8 July 2018

Division of labor, plasticity, and crosstalk between dendritic cell subsets.

1 reference

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8 July 2018

Migration of dendritic cell subsets and their precursors.

1 reference

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8 July 2018

An ITAM-signaling pathway controls cross-presentation of particulate but not soluble antigens in dendritic cells

1 reference

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8 July 2018

Taking dendritic cells into medicine

1 reference

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Distinct pathways of antigen uptake and intracellular routing in CD4 and CD8 T cell activation.

1 reference

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8 July 2018

Distinct uptake mechanisms but similar intracellular processing of two different toll-like receptor ligand-peptide conjugates in dendritic cells

1 reference

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8 July 2018

Immunotherapeutic activity of a conjugate of a Toll-like receptor 7 ligand

1 reference

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8 July 2018

Differential antigen processing by dendritic cell subsets in vivo

1 reference

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Cutting edge: activation of murine TLR8 by a combination of imidazoquinoline immune response modifiers and polyT oligodeoxynucleotides

1 reference

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8 July 2018

Vaccination with recombinant fusion proteins incorporating Toll-like receptor ligands induces rapid cellular and humoral immunity

1 reference

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Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection

1 reference

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The dominant role of CD8+ dendritic cells in cross-presentation is not dictated by antigen capture

1 reference

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Toll-like receptor agonists influence the magnitude and quality of memory T cell responses after prime-boost immunization in nonhuman primates

1 reference

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Translating innate immunity into immunological memory: implications for vaccine development

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Epidermal langerhans cell-deficient mice develop enhanced contact hypersensitivity

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HIV Gag protein conjugated to a Toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8+ T cell responses in nonhuman primates

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Antigen persistence is required throughout the expansion phase of a CD4(+) T cell response

1 reference

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1 reference

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Cell biology of antigen processing in vitro and in vivo

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Phagosomes are competent organelles for antigen cross-presentation

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ER-phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells

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8 July 2018

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Vaginal submucosal dendritic cells, but not Langerhans cells, induce protective Th1 responses to herpes simplex virus-2

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8 July 2018

CpG-DNA aided cross-presentation of soluble antigens by dendritic cells

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8 July 2018

Interferon-alpha and interleukin-12 are induced differentially by Toll-like receptor 7 ligands in human blood dendritic cell subsets

1 reference

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8 July 2018

Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides

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Mouse and human dendritic cell subtypes

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Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens

1 reference

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Toll-like receptors: critical proteins linking innate and acquired immunity

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A new mathematical model for relative quantification in real-time RT-PCR

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CD8(+) but not CD8(-) dendritic cells cross-prime cytotoxic T cells in vivo.

1 reference

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Conjugation of protein to immunostimulatory DNA results in a rapid, long-lasting and potent induction of cell-mediated and humoral immunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083762

8 July 2018

Immunostimulatory DNA-based vaccines induce cytotoxic lymphocyte activity by a T-helper cell-independent mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083762

8 July 2018

Natural adjuvants: endogenous activators of dendritic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083762

8 July 2018

Type I interferons keep activated T cells alive

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083762

8 July 2018

Induction of bystander T cell proliferation by viruses and type I interferon in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083762

8 July 2018

Efficient major histocompatibility complex class I presentation of exogenous antigen upon phagocytosis by macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083762

8 July 2018

Quantitative proteomics reveals subset-specific viral recognition in dendritic cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083762

26 October 2018

Cutting edge: polyinosinic:polycytidylic acid boosts the generation of memory CD8 T cells through melanoma differentiation-associated protein 5 expressed in stromal cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083762

26 October 2018

Cutting edge: priming of CD8 T cell immunity to herpes simplex virus type 1 requires cognate TLR3 expression in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083762

26 October 2018

Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083762

26 October 2018

Plasmacytoid dendritic cells efficiently cross-prime naive T cells in vivo after TLR activation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083762

26 October 2018

Spatial and mechanistic separation of cross-presentation and endogenous antigen presentation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083762

26 October 2018

Amine reactive dyes: an effective tool to discriminate live and dead cells in polychromatic flow cytometry.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083762

26 October 2018

Immunization with HIV-1 Gag protein conjugated to a TLR7/8 agonist results in the generation of HIV-1 Gag-specific Th1 and CD8+ T cell responses.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083762

26 October 2018

Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083762

26 October 2018

Toll-like receptor 3 promotes cross-priming to virus-infected cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083762

26 October 2018

Control of cross-presentation during dendritic cell maturation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083762

26 October 2018

The Toll‐like receptor 7 (TLR7)‐specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083762

26 October 2018

Cross-priming of CD8+ T cells stimulated by virus-induced type I interferon

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083762

26 October 2018

The immune response modifier and Toll-like receptor 7 agonist S-27609 selectively induces IL-12 and TNF-alpha production in CD11c+CD11b+CD8- dendritic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083762

26 October 2018

Toll-like receptor expression in murine DC subsets: lack of TLR7 expression by CD8 alpha+ DC correlates with unresponsiveness to imidazoquinolines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083762

26 October 2018

Plasmacytoid dendritic cells produce cytokines and mature in response to the TLR7 agonists, imiquimod and resiquimod

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083762

26 October 2018

Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083762

26 October 2018

Inflammatory mediators are insufficient for full dendritic cell activation and promote expansion of CD4+ T cell populations lacking helper function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083762

9 December 2018

Enhanced Dendritic Cell Antigen Capture via Toll-Like Receptor-Induced Actin Remodeling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083762

9 December 2018

Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083762

9 December 2018

Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083762

9 December 2018

Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/21540549

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epidermal and dermal dendritic cells display differential activation and migratory behavior while sharing the ability to stimulate CD4+ T cell proliferation in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/21540549

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitation of dihydropyrimidine dehydrogenase expression by real-time reverse transcription polymerase chain reaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/21540549

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cutting Edge: Intravenous Soluble Antigen Is Presented to CD4 T Cells by CD8- Dendritic Cells, but Cross-Presented to CD8 T Cells by CD8+ Dendritic Cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21540549

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of CCR-7, MIP-3beta , and Th-1 chemokines in type I IFN-induced monocyte-derived dendritic cells: importance for the rapid acquisition of potent migratory and functional activities

1 reference

https://pubmed.ncbi.nlm.nih.gov/21540549

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21540549

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Roles of proteasomes, transporter for antigen presentation (TAP), and beta 2-microglobulin in the processing of bacterial or particulate antigens via an alternate class I MHC processing pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/21540549

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induced recruitment of NK cells to lymph nodes provides IFN-gamma for T(H)1 priming

1 reference

https://pubmed.ncbi.nlm.nih.gov/21540549

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct Stimulation of T Cells by Type I IFN Enhances the CD8+ T Cell Response during Cross-Priming

1 reference

https://pubmed.ncbi.nlm.nih.gov/21540549

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toll-dependent selection of microbial antigens for presentation by dendritic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21540549

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of intestinal dendritic cell migration and activation by plasmacytoid dendritic cells, TNF-alpha and type 1 IFNs after feeding a TLR7/8 ligand

1 reference

https://pubmed.ncbi.nlm.nih.gov/21540549

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Langerin Expressing Cells Promote Skin Immune Responses under Defined Conditions

1 reference

https://pubmed.ncbi.nlm.nih.gov/21540549

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1172/JCI45416

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21540549%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21540549%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21540549%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

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