(Q34921957)

English

Carboxymefloquine, the major metabolite of the antimalarial drug mefloquine, induces drug-metabolizing enzyme and transporter expression by activation of pregnane X receptor

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1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Carboxymefloquine, the major metabolite of the antimalarial drug mefloquine, induces drug-metabolizing enzyme and transporter expression by activation of pregnane X receptor (English)

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

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1 reference

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author name string

Rita Piedade

1

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Stefanie Traub

2

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Andreas Bitter

3

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Andreas K Nüssler

4

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

José P Gil

5

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Matthias Schwab

6

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Oliver Burk

7

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

language of work or name

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publication date

13 October 2014

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Antimicrobial Agents and Chemotherapy

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Europe PubMed Central

PubMed publication ID

5 August 2017

59

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Europe PubMed Central

PubMed publication ID

5 August 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

96-104

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Emerging artemisinin resistance in the border areas of Thailand

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291335

8 July 2018

Tuberculosis with malaria or HIV co-infection in a large hospital in Luanda, Angola.

1 reference

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8 July 2018

Differential effects of clinically used derivatives and metabolites of artemisinin in the activation of constitutive androstane receptor isoforms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291335

8 July 2018

Role of CAR and PXR in xenobiotic sensing and metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291335

8 July 2018

Effects of atorvastatin metabolites on induction of drug-metabolizing enzymes and membrane transporters through human pregnane X receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291335

8 July 2018

The position of mefloquine as a 21st century malaria chemoprophylaxis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291335

8 July 2018

Nuclear receptors CAR and PXR: Molecular, functional, and biomedical aspects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291335

8 July 2018

Gene expression profiling of potential peroxisome proliferator-activated receptor (PPAR) target genes in human hepatoblastoma cell lines inducibly expressing different PPAR isoforms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291335

8 July 2018

Antimalarial artemisinin drugs induce cytochrome P450 and MDR1 expression by activation of xenosensors pregnane X receptor and constitutive androstane receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291335

8 July 2018

Alternative splicing affects the function and tissue-specific expression of the human constitutive androstane receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291335

8 July 2018

Population pharmacokinetic and pharmacodynamic modelling of artemisinin and mefloquine enantiomers in patients with falciparum malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291335

8 July 2018

Natural protein variants of pregnane X receptor with altered transactivation activity toward CYP3A4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291335

8 July 2018

Pharmacokinetic interactions of antimalarial agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291335

8 July 2018

Pharmacokinetic interaction between mefloquine and ritonavir in healthy volunteers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291335

8 July 2018

Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291335

8 July 2018

Dexamethasone enhances constitutive androstane receptor expression in human hepatocytes: consequences on cytochrome P450 gene regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291335

8 July 2018

Dynamic stabilization of nuclear receptor ligand binding domains by hormone or corepressor binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291335

8 July 2018

Identification of the human cytochrome P450 enzymes involved in the in vitro metabolism of artemisinin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291335

8 July 2018

PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291335

8 July 2018

Single dose kinetics of mefloquine in man. Plasma levels of the unchanged drug and of one of its metabolites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291335

8 July 2018

Use of mefloquine in epileptic patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291335

8 July 2018

Absence of antimalarial activity or interaction with mefloquine enantiomers in vitro of the main human metabolite of mefloquine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291335

8 July 2018

Primaquine metabolism by human liver microsomes: effect of other antimalarial drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291335

8 July 2018

Studies of the disposition and metabolism of mefloquine HCl (WR 142,490), a quinolinemethanol antimalarial, in the rat. Limited studies with an analog, WR 30,090

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291335

8 July 2018

Artemisinin autoinduction is caused by involvement of cytochrome P450 2B6 but not 2C9.

1 reference

https://api.crossref.org/works/10.1128%2FAAC.04140-14

21 January 2018

Artemisinin antimalarials moderately affect cytochrome P450 enzyme activity in healthy subjects

1 reference

https://api.crossref.org/works/10.1128%2FAAC.04140-14

21 January 2018

Evaluation of P450 inhibition and induction by artemisinin antimalarials in human liver microsomes and primary human hepatocytes

1 reference

https://api.crossref.org/works/10.1128%2FAAC.04140-14

21 January 2018

Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification

1 reference

https://api.crossref.org/works/10.1128%2FAAC.04140-14

21 January 2018

In vivo and mechanistic evidence of nuclear receptor CAR induction by artemisinin.

1 reference

https://api.crossref.org/works/10.1128%2FAAC.04140-14

21 January 2018

A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression

1 reference

https://api.crossref.org/works/10.1128%2FAAC.04140-14

21 January 2018

Molecular mechanisms of polymorphic CYP3A7 expression in adult human liver and intestine

1 reference

https://api.crossref.org/works/10.1128%2FAAC.04140-14

21 January 2018

UDP-glucuronosyltransferase (UGT) polymorphisms affect atorvastatin lactonization in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1128%2FAAC.04140-14

21 January 2018

Effect of rifampin on plasma concentrations of mefloquine in healthy volunteers.

1 reference

https://api.crossref.org/works/10.1128%2FAAC.04140-14

21 January 2018

Ketoconazole increases plasma concentrations of antimalarial mefloquine in healthy human volunteers

1 reference

https://api.crossref.org/works/10.1128%2FAAC.04140-14

21 January 2018

Kinetic studies of mefloquine and of one of its metabolites, Ro 21-5104, in the dog and in man.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291335

26 October 2018

Human Hepatocytes: Isolation, Culture, and Quality Procedures

1 reference

https://api.crossref.org/works/10.1128%2FAAC.04140-14

21 January 2018

Role of cytochrome P450 3A in the metabolism of mefloquine in human and animal hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/25313206

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple-dose kinetic study of mefloquine in healthy male volunteers

1 reference

https://pubmed.ncbi.nlm.nih.gov/25313206

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human liver carbamazepine metabolism. Role of CYP3A4 and CYP2C8 in 10,11-epoxide formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/25313206

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contribution of CYP2C9, CYP2A6, and CYP2B6 to valproic acid metabolism in hepatic microsomes from individuals with the CYP2C9*1/*1 genotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/25313206

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/AAC.04140-14

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

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