(Q34931908)

5 August 2017

1 reference

title

Development of alphabeta T cells in the human thymus (English)

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5 August 2017

1

Hergen Spits

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5 August 2017

1 October 2002

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Nature Reviews Immunology

5 August 2017

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5 August 2017

2

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5 August 2017

10

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5 August 2017

760-772

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Transplantation of thymus tissue in complete DiGeorge syndrome

5 August 2017

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IMMUNOLOGICAL FUNCTION OF THE THYMUS

31 March 2020

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Inhibition of T cell and promotion of natural killer cell development by the dominant negative helix loop helix factor Id3.

31 March 2020

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Naturally occurring primary deficiencies of the immune system

31 March 2020

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Identification of a common T/natural killer cell progenitor in human fetal thymus.

31 March 2020

1 reference

Identification of a myeloid intrathymic pathway of dendritic cell development marked by expression of the granulocyte macrophage-colony-stimulating factor receptor.

31 March 2020

1 reference

Id2 and Id3 inhibit development of CD34(+) stem cells into predendritic cell (pre-DC)2 but not into pre-DC1. Evidence for a lymphoid origin of pre-DC2.

31 March 2020

1 reference

Intrathymic and extrathymic development of human plasmacytoid dendritic cell precursors in vivo

31 March 2020

1 reference

Commitment of common T/Natural killer (NK) progenitors to unipotent T and NK progenitors in the murine fetal thymus revealed by a single progenitor assay

31 March 2020

1 reference

Clonal Characterization of a Bipotent T Cell and NK Cell Progenitor in the Mouse Fetal Thymus

31 March 2020

1 reference

Mapping precursor movement through the postnatal thymus reveals specific microenvironments supporting defined stages of early lymphoid development

31 March 2020

1 reference

Immature human thymocytes can be driven to differentiate into nonlymphoid lineages by cytokines from thymic epithelial cells

31 March 2020

1 reference

Precursors of CD3+CD4+CD8+ cells in the human thymus are defined by expression of CD34. Delineation of early events in human thymic development

31 March 2020

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Early stages in the development of human T, natural killer and thymic dendritic cells.

31 March 2020

1 reference

Transcriptional regulation of T lymphocyte development and function

31 March 2020

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To be or not to be a pro-T?

31 March 2020

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The function of E- and Id proteins in lymphocyte development

31 March 2020

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Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2.

31 March 2020

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Commitment to natural killer cells requires the helix-loop-helix inhibitor Id2

31 March 2020

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Disruption of alpha beta but not of gamma delta T cell development by overexpression of the helix-loop-helix protein Id3 in committed T cell progenitors

31 March 2020

1 reference

Deficient T cell fate specification in mice with an induced inactivation of Notch1.

31 March 2020

1 reference

An invitation to T and more: notch signaling in lymphopoiesis

31 March 2020

1 reference

Active form of Notch imposes T cell fate in human progenitor cells

31 March 2020

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Notch1 expression in early lymphopoiesis influences B versus T lineage determination.

31 March 2020

1 reference

Differential effects of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation

31 March 2020

1 reference

Cytokines and immunodeficiency diseases

31 March 2020

1 reference

Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.

31 March 2020

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Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice

31 March 2020

1 reference

Defective human interleukin 2 receptor gamma chain in an atypical X chromosome-linked severe combined immunodeficiency with peripheral T cells

31 March 2020

1 reference

Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans

31 March 2020

1 reference

Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency

31 March 2020

1 reference

Atypical X-Linked Severe Combined Immunodeficiency Due to Possible Spontaneous Reversion of the Genetic Defect in T Cells

31 March 2020

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Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy

31 March 2020

1 reference

Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID

31 March 2020

1 reference

Interleukin-7 induces the association of phosphatidylinositol 3-kinase with the alpha chain of the interleukin-7 receptor

31 March 2020

1 reference

The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15.

31 March 2020

1 reference

Distinct roles of the phosphatidylinositol 3-kinase and STAT5 pathways in IL-7-mediated development of human thymocyte precursors

31 March 2020

1 reference

The role of Stat5a and Stat5b in signaling by IL-2 family cytokines

31 March 2020

1 reference

Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)

31 March 2020

1 reference

Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development.

31 March 2020

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Defective lymphoid development in mice lacking Jak3

31 March 2020

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IL-7 receptor and VDJ recombination: trophic versus mechanistic actions

31 March 2020

1 reference

The V-J recombination of T cell receptor-gamma genes is blocked in interleukin-7 receptor-deficient mice

31 March 2020

1 reference

Interleukin 7 receptor control of T cell receptor gamma gene rearrangement: role of receptor-associated chains and locus accessibility

31 March 2020

1 reference

Induction of germline transcription in the TCRgamma locus by Stat5: implications for accessibility control by the IL-7 receptor

31 March 2020

1 reference

Effects of exogenous interleukin-7 on human thymus function

31 March 2020

1 reference

Differentiation of CD3-4-8- human fetal thymocytes in vivo: characterization of a CD3-4+8- intermediate

31 March 2020

1 reference

Regulation of pre-T cell receptor (pT alpha-TCR beta) gene expression during human thymic development.

31 March 2020

1 reference

Structure and function of the pre-T cell receptor

31 March 2020

1 reference

Productive T-cell receptor beta-chain gene rearrangement: coincident regulation of cell cycle and clonality during development in vivo.

31 March 2020

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On the role of the pre-T cell receptor in alphabeta versus gammadelta T lineage commitment.

31 March 2020

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SCL and LMO1 alter thymocyte differentiation: inhibition of E2A-HEB function and pre-T alpha chain expression

31 March 2020

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The upstream enhancer is necessary and sufficient for the expression of the pre-T cell receptor alpha gene in immature T lymphocytes

31 March 2020

1 reference

Identification of a late stage of small noncycling pTalpha- pre-T cells as immediate precursors of T cell receptor alpha/beta+ thymocytes

31 March 2020

1 reference

PJA-BP expression and TCR delta deletion during human T cell differentiation

31 March 2020

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Regulation of RAG-1 and CD69 expression in the thymus during positive and negative selection

31 March 2020

1 reference

The bare lymphocyte syndrome and the regulation of MHC expression

31 March 2020

1 reference

CD1-restricted CD4+ T cells in major histocompatibility complex class II-deficient mice

31 March 2020

1 reference

ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency

31 March 2020

1 reference

Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase

31 March 2020

1 reference

Absence of ZAP-70 prevents signaling through the antigen receptor on peripheral blood T cells but not on thymocytes

31 March 2020

1 reference

Alternative antigen receptor (TCR) signaling in T cells derived from ZAP-70-deficient patients expressing high levels of Syk

31 March 2020

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Antigen recognition by MHC-incompatible cells of a human mismatched chimera

31 March 2020

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Presence of host-reactive and MHC-restricted T cells in a transplanted severe combined immunodeficient (SCID) patient suggest positive selection and absence of clonal deletion

31 March 2020

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Thymic selection of the human T cell receptor V beta repertoire in SCID-hu mice

31 March 2020

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Human hematopoietic cells and thymic epithelial cells induce tolerance via different mechanisms in the SCID-hu mouse thymus

31 March 2020

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Chimerism and tolerance to host and donor in severe combined immunodeficiencies transplanted with fetal liver stem cells

31 March 2020

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High levels of interleukin 10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoietic stem cells.

31 March 2020

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Human CD4(+)CD25(+) thymocytes and peripheral T cells have immune suppressive activity in vitro

31 March 2020

1 reference

Phenotype, localization, and mechanism of suppression of CD4(+)CD25(+) human thymocytes

31 March 2020

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Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4(+)25(+) immunoregulatory T cells

31 March 2020

1 reference

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

31 March 2020

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Thymic selection generates a large T cell pool recognizing a self-peptide in humans

31 March 2020

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A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas

31 March 2020

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Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor

31 March 2020

1 reference

High frequency of skin-homing melanocyte-specific cytotoxic T lymphocytes in autoimmune vitiligo

31 March 2020

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Thymic function can be accurately monitored by the level of recent T cell emigrants in the circulation

31 March 2020

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Changes in thymic function with age and during the treatment of HIV infection

31 March 2020

1 reference

T cell receptor excision circles as markers for recent thymic emigrants: basic aspects, technical approach, and guidelines for interpretation

31 March 2020

1 reference

Reevaluation of T cell receptor excision circles as a measure of human recent thymic emigrants.

31 March 2020

1 reference

Effect of thymectomy on human peripheral blood T cell pools in myasthenia gravis

31 March 2020

1 reference

Two subsets of naive T helper cells with distinct T cell receptor excision circle content in human adult peripheral blood

31 March 2020

1 reference

Identification of a human recent thymic emigrant phenotype

31 March 2020

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Thymic involution with ageing: obsolescence or good housekeeping?

31 March 2020

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Analysis of the human thymic perivascular space during aging

31 March 2020

1 reference

The involution of the ageing human thymic epithelium is independent of puberty. A morphometric study

31 March 2020

1 reference

Analysis of the adult thymus in reconstitution of T lymphocytes in HIV-1 infection

31 March 2020

1 reference

The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection

31 March 2020

1 reference

Phenotypic and Immunohistological Analyses of the Human Adult Thymus: Evidence for an Active Thymus during Adult Life

31 March 2020

1 reference

Generation of functional thymocytes in the human adult.

31 March 2020

1 reference

Thymic function after hematopoietic stem-cell transplantation for the treatment of severe combined immunodeficiency

31 March 2020

1 reference

Hematopoietic stem cell transplantation for severe combined immunodeficiency in the neonatal period leads to superior thymic output and improved survival

31 March 2020

1 reference

Age, thymopoiesis, and CD4+ T-lymphocyte regeneration after intensive chemotherapy

31 March 2020

1 reference

Assessment of thymic output in adults after haematopoietic stem-cell transplantation and prediction of T-cell reconstitution

31 March 2020

1 reference

CD45 isoform phenotypes of human T cells: CD4(+)CD45RA(-)RO(+) memory T cells re-acquire CD45RA without losing CD45RO.

31 March 2020

1 reference

High prevalence of thymic tissue in adults with human immunodeficiency virus-1 infection.

31 March 2020

1 reference

The role of the thymus and recent thymic migrants in the maintenance of the adult peripheral lymphocyte pool

31 March 2020

1 reference

T-cell receptor excision circle and T-cell dynamics after allogeneic stem cell transplantation are related to clinical events

31 March 2020

1 reference

HIV induces thymus depletion in vivo

31 March 2020

1 reference

The SCID-hu mouse as a model for HIV-1 infection

31 March 2020

1 reference

Early Progression of Disease in HIV-Infected Infants with Thymus Dysfunction

31 March 2020

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Impact of cytokines on replication in the thymus of primary human immunodeficiency virus type 1 isolates from infants

31 March 2020

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Impaired replication of protease inhibitor-resistant HIV-1 in human thymus.

31 March 2020

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Increased production of IL-7 accompanies HIV-1-mediated T-cell depletion: implications for T-cell homeostasis

31 March 2020

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A potential role for interleukin-7 in T-cell homeostasis

31 March 2020

1 reference

Poor CD4 T cell restoration after suppression of HIV-1 replication may reflect lower thymic function

31 March 2020

1 reference

T cell receptor excision circle (TREC) content following maximum HIV suppression is equivalent in HIV-infected and HIV-uninfected individuals

31 March 2020

1 reference

T-cell repopulation and thymic volume in HIV-1-infected adult patients after highly active antiretroviral therapy

31 March 2020

1 reference

Evidence for increased T cell turnover and decreased thymic output in HIV infection

31 March 2020

1 reference

Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection

31 March 2020

1 reference

Measuring recent thymic emigrants in blood of normal and HIV-1-infected individuals before and after effective therapy

31 March 2020

1 reference

Perturbation of CD4+ and CD8+ T-cell repertoires during progression to AIDS and regulation of the CD4+ repertoire during antiviral therapy

31 March 2020

1 reference

Peripheral expansion of pre-existing mature T cells is an important means of CD4+ T-cell regeneration HIV-infected adults.

31 March 2020

1 reference

T cell depletion in HIV-1 infection: how CD4+ T cells go out of stock

31 March 2020

1 reference

Interleukin-7: from bench to clinic

31 March 2020

1 reference

The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function

31 March 2020

1 reference

A single stem cell can recolonize an embryonic thymus, producing phenotypically distinct T-cell populations

31 March 2020

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Human thymocyte development in mouse organ cultures

31 March 2020

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Human natural killer cell committed thymocytes and their relation to the T cell lineage

31 March 2020

1 reference

Human T, B, natural killer, and dendritic cells arise from a common bone marrow progenitor cell subset

31 March 2020

1 reference

Deletion of the human T-cell receptor δ-gene by a site-specific recombination

31 March 2020

1 reference

T cell receptor gene deletion circles identify recent thymic emigrants in the peripheral T cell pool

31 March 2020

1 reference

Notch1 deficiency dissociates the intrathymic development of dendritic cells and T cells.

31 March 2020

1 reference

Differential developmental regulation and functional effects on pre-TCR surface expression of human pTalpha(a) and pTalpha(b) spliced isoforms.

31 March 2020

1 reference

Downregulation of CD1 marks acquisition of functional maturation of human thymocytes and defines a control point in late stages of human T cell development

31 March 2020

1 reference

Defective T cell receptor signaling and CD8+ thymic selection in humans lacking zap-70 kinase

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

R5 strains of human immunodeficiency virus type 1 from rapid progressors lacking X4 strains do not possess X4-type pathogenicity in human thymus.

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRI913

1 reference

5 August 2017

1 reference

PubMed ID

12360214