(Q34932177)

5 August 2017

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title

Toll-like receptors as potential therapeutic targets for multiple diseases (English)

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5 August 2017

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Claudia Zuany-Amorim

1

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5 August 2017

John Hastewell

series ordinal

2

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5 August 2017

Christoph Walker

series ordinal

3

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5 August 2017

publication date

1 October 2002

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Nature Reviews Drug Discovery

5 August 2017

published in

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5 August 2017

volume

1

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5 August 2017

issue

10

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5 August 2017

page(s)

797-807

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https://scigraph.springernature.com/pub.10.1038/nrd914

5 August 2017

exact match

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cites work

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Signaling by toll-like receptor 2 and 4 agonists results in differential gene expression in murine macrophages.

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The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

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A Toll-like receptor recognizes bacterial DNA

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Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins

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MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways

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IRAK: a kinase associated with the interleukin-1 receptor

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TRAF6 is a signal transducer for interleukin-1

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Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

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Toll-like receptor signal transduction and the tailoring of innate immunity: a role for Mal?

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Molecules and mechanisms operating in septic shock: lessons from knockout mice

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Cardiac inflammation and innate immunity in septic shock: is there a role for toll-like receptors?

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Bench-to-bedside review: Toll-like receptors and their role in septic shock

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TH2 and 'TH2-like' cells in allergy and asthma: pharmacological perspectives

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Induction and regulation of the IgE response

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Molecular mechanisms of IgE regulation

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Asthma. From bronchoconstriction to airways inflammation and remodeling

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Immunologic basis of antigen-induced airway hyperresponsiveness

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The role of allergy in the development of asthma

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The inverse association between tuberculin responses and atopic disorder.

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Frequency of infections and risk of asthma, atopy and airway hyperresponsiveness in children

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Antibiotic use in early childhood and the development of asthma

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Infection of mice with Mycobacterium bovis-Bacillus Calmette-Guérin (BCG) suppresses allergen-induced airway eosinophilia

21 January 2018

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Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus

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Endotoxin, atopy and asthma

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A defective type 1 response to rhinovirus in atopic asthma.

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Lipopolysaccharides from distinct pathogens induce different classes of immune responses in vivo

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BCG infection suppresses allergic sensitization and development of increased airway reactivity in an animal model.

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Atopic disorders: a vaccine around the corner?

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Inhibition of an established allergic response to ovalbumin in BALB/c mice by killed Mycobacterium vaccae

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Intradermal administration of a killed Mycobacterium vaccae suspension (SRL 172) is associated with improvement in atopic dermatitis in children with moderate-to-severe disease

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House dust endotoxin and wheeze in the first year of life

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Association of a promoter polymorphism of the CD14 gene and atopy

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Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway

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Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848

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Imiquimod: a new immune response modifier for the treatment of external genital warts and other diseases in dermatology

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CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma

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Mechanisms and applications of immune stimulatory CpG oligodeoxynucleotides

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Conjugation of immunostimulatory DNA to the short ragweed allergen amb a 1 enhances its immunogenicity and reduces its allergenicity

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CpG motifs in bacterial DNA and their immune effects

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A role for CD45RBlow CD38+ T cells and costimulatory pathways of T-cell activation in protection of non-obese diabetic (NOD) mice from diabetes

21 January 2018

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The role of different subsets of T regulatory cells in controlling autoimmunity

21 January 2018

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Regulatory T cells in the control of immune pathology.

21 January 2018

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Approaching the asymptote? Evolution and revolution in immunology

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The immune system evolved to discriminate infectious nonself from noninfectious self

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Exacerbations: etiology and pathophysiologic mechanisms

21 January 2018

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Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses

21 January 2018

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Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

21 January 2018

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A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

21 January 2018

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Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses

21 January 2018

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Tolerance, danger, and the extended family

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The danger model: a renewed sense of self

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Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex

21 January 2018

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HSP70 as endogenous stimulus of the Toll/interleukin-1 receptor signal pathway

21 January 2018

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Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4.

21 January 2018

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Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4.

21 January 2018

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Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4.

21 January 2018

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Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

21 January 2018

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The role of heat shock proteins and their receptors in the activation of the immune system

21 January 2018

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The humoral immune response to heat shock proteins

21 January 2018

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Heat shock (stress) proteins and autoimmunity in rheumatic diseases

21 January 2018

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Inflammatory response after open heart surgery: release of heat-shock protein 70 and signaling through toll-like receptor-4.

21 January 2018

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Cardiopulmonary bypass: studies on its damaging effects.

21 January 2018

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Systemic inflammatory response syndrome after cardiac operations.

21 January 2018

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Modulation of the expression of cyclooxygenase-2 by fatty acids mediated through toll-like receptor 4-derived signaling pathways

21 January 2018

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Biochemistry of endotoxins

21 January 2018

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Does the shape of lipid A determine the interaction of LPS with Toll-like receptors?

21 January 2018

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Hyaluronan fragments activate an NF-kappa B/I-kappa B alpha autoregulatory loop in murine macrophages

21 January 2018

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A randomized study of the effect of withdrawing hydroxychloroquine sulfate in systemic lupus erythematosus

21 January 2018

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Suppression of airway eosinophilia by killed Mycobacterium vaccae-induced allergen-specific regulatory T-cells

21 January 2018

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The role of clonal selection and somatic mutation in autoimmunity

21 January 2018

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Genetic 'risk' for atopy is associated with delayed postnatal maturation of T-cell competence

21 January 2018

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Unresponsiveness of MyD88-deficient mice to endotoxin

21 January 2018

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Endotoxin-induced maturation of MyD88-deficient dendritic cells

31 March 2020

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Strategies for the treatment of sepsis

31 March 2020

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Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma

31 March 2020

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Toll-like receptors control activation of adaptive immune responses

31 March 2020

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Mechanisms of asthma exacerbation

31 March 2020

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Could the risk of asthma and atopy be reduced by a vaccine that induces a strong T-helper type 1 response?

31 March 2020

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The effect of delipidated deglycolipidated (DDMV) and heat-killed Mycobacterium vaccae in asthma

31 March 2020

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Relation between house-dust endotoxin exposure, type 1 T-cell development, and allergen sensitisation in infants at high risk of asthma

31 March 2020

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Lipopolysaccharide augments IgG and IgE responses of mice to the latex allergen Hev b 5

31 March 2020

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Toll-like receptors 2 and 4 are up-regulated during intestinal inflammation

31 March 2020

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Cutting edge: the immunostimulatory activity of the lung surfactant protein-A involves Toll-like receptor 4

31 March 2020

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Heat shock proteins in cardiosurgery patients

31 March 2020

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Heat-shock proteins as activators of the innate immune system

31 March 2020

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Reactive oxygen species contribute to epidermal hyaluronan catabolism in human skin organ culture

31 March 2020

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A model for the role of hyaluronic acid and fibrin in the early events during the inflammatory response and wound healing

31 March 2020

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Oligosaccharides of hyaluronan are potent activators of dendritic cells

31 March 2020

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Immune complexes present in the sera of autoimmune mice activate rheumatoid factor B cells

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRD914

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5 August 2017

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