(Q34947329)

5 August 2017

title

Quantitative cell-based protein degradation assays to identify and classify drugs that target the ubiquitin-proteasome system (English)

1 reference

ubiquitin-proteasome system

5 August 2017

main subject

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author name string

Tsui-Fen Chou

series ordinal

1

1 reference

5 August 2017

Raymond J Deshaies

series ordinal

2

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5 August 2017

language of work or name

English

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publication date

22 February 2011

1 reference

Journal of Biological Chemistry

5 August 2017

published in

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5 August 2017

volume

286

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5 August 2017

issue

19

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5 August 2017

page(s)

16546-16554

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Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways

5 August 2017

cites work

1 reference

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Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase

8 July 2018

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Identification of a primary target of thalidomide teratogenicity

8 July 2018

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Targeting proteins for degradation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089497

A conserved unfoldase activity for the p97 AAA-ATPase in proteasomal degradation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089497

Cytomegalovirus promoter up-regulation is the major cause of increased protein levels of unstable reporter proteins after treatment of living cells with proteasome inhibitors

8 July 2018

1 reference

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Therapeutic strategies within the ubiquitin proteasome system.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089497

Recognition and processing of ubiquitin-protein conjugates by the proteasome

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089497

RING domain E3 ubiquitin ligases

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089497

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089497

Impaired protein aggregate handling and clearance underlie the pathogenesis of p97/VCP-associated disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089497

Inhibition of p97-dependent protein degradation by Eeyarestatin I

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089497

Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089497

HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089497

The ubiquitin-selective chaperone CDC-48/p97 links myosin assembly to human myopathy

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089497

HDAC6-p97/VCP controlled polyubiquitin chain turnover

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089497

Central pore residues mediate the p97/VCP activity required for ERAD

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089497

Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089497

ATPase activity of p97/valosin-containing protein is regulated by oxidative modification of the evolutionally conserved cysteine 522 residue in Walker A motif

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089497

Ubx2 links the Cdc48 complex to ER-associated protein degradation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089497

Bortezomib, a newly approved proteasome inhibitor for the treatment of multiple myeloma: nursing implications

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089497

A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089497

Elevated expression of valosin-containing protein (p97) is associated with poor prognosis of prostate cancer

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089497

Velcade: U.S. FDA approval for the treatment of multiple myeloma progressing on prior therapy

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089497

The AAA-ATPase Cdc48/p97 regulates spindle disassembly at the end of mitosis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089497

Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089497

Determinants of proteasome recognition of ornithine decarboxylase, a ubiquitin-independent substrate

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089497

Functional profiling of the Saccharomyces cerevisiae genome

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089497

An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089497

Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089497

The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089497

Impairment of the ubiquitin-proteasome system by protein aggregation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089497

Themes and variations on ubiquitylation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089497

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089497

An NSF-like ATPase, p97, and NSF mediate cisternal regrowth from mitotic Golgi fragments

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089497

Targeted deletion of p97 (VCP/CDC48) in mouse results in early embryonic lethality.

8 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.215319

Expression level of valosin-containing protein (p97) is associated with prognosis of esophageal carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.215319

Elevated expression of valosin-containing protein (p97) in hepatocellular carcinoma is correlated with increased incidence of tumor recurrence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.215319

Expression level of valosin-containing protein (p97) is correlated with progression and prognosis of non-small-cell lung carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.215319

Absence of Bax switched MG132-induced apoptosis to non-apoptotic cell death that could be suppressed by transcriptional or translational inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.215319

Towards subunit-specific proteasome inhibitors: synthesis and evaluation of peptide alpha',beta'-epoxyketones.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.215319

Beta-nitrostyrene derivatives as potential antibacterial agents: a structure-property-activity relationship study

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.215319

Synthesis and pharmacological evaluation of novel beta-nitrostyrene derivatives as tyrosine kinase inhibitors with potent antiplatelet activity

21 January 2018

1 reference

12 December 2020

Short-lived green fluorescent proteins for quantifying ubiquitin/proteasome-dependent proteolysis in living cells

1 reference

12 December 2020

Small-molecule inhibitors of the p53-HDM2 interaction for the treatment of cancer

1 reference

12 December 2020

Selective inhibitors of the proteasome-dependent and vacuolar pathways of protein degradation in Saccharomyces cerevisiae

1 reference

12 December 2020

The Janus face of the archaeal Cdc48/p97 homologue VAT: protein folding versus unfolding

1 reference

12 December 2020

A series of ubiquitin binding factors connects CDC48/p97 to substrate multiubiquitylation and proteasomal targeting

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M110.215319

1 reference

5 August 2017

1 reference

5 August 2017

1 reference