(Q42022306)

15 October 2017

Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase (English)

1 reference

15 October 2017

1 reference

17

Kendall N Houk

1 reference

15 October 2017

Mariam Aghajan

1

1 reference

15 October 2017

Nao Jonai

2

1 reference

15 October 2017

Karin Flick

3

1 reference

15 October 2017

Fei Fu

4

1 reference

15 October 2017

Manlin Luo

5

1 reference

15 October 2017

Xiaolu Cai

6

1 reference

15 October 2017

Ikram Ouni

7

1 reference

15 October 2017

Nathan Pierce

8

1 reference

15 October 2017

Xiaobo Tang

9

1 reference

15 October 2017

Brett Lomenick

10

1 reference

15 October 2017

Robert Damoiseaux

11

1 reference

15 October 2017

Rui Hao

12

1 reference

15 October 2017

Pierre M Del Moral

13

1 reference

15 October 2017

Rati Verma

14

1 reference

15 October 2017

Ying Li

15

1 reference

15 October 2017

Cheng Li

16

1 reference

15 October 2017

Michael E Jung

18

1 reference

15 October 2017

Ning Zheng

19

1 reference

15 October 2017

Lan Huang

20

1 reference

15 October 2017

Raymond J Deshaies

21

1 reference

15 October 2017

Peter Kaiser

22

1 reference

15 October 2017

Jing Huang

23

1 reference

15 October 2017

27 June 2010

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15 October 2017

1 reference

15 October 2017

28

1 reference

15 October 2017

7

1 reference

15 October 2017

738-742

1 reference

https://scigraph.springernature.com/pub.10.1038/nbt.1645

15 October 2017

0 references

cites work

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902569

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902569

Targeting the p27 E3 ligase SCF(Skp2) results in p27- and Skp2-mediated cell-cycle arrest and activation of autophagy

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902569

Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902569

Targeting the mTOR signaling network in cancer.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902569

The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902569

Defining the role of mTOR in cancer

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902569

Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902569

S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902569

5 June 2018

mTOR and cancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902569

mTOR pathway as a target in tissue hypertrophy.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902569

Drug discovery in the ubiquitin-proteasome system.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902569

Ras, PI(3)K and mTOR signalling controls tumour cell growth

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902569

TOR signaling in growth and metabolism

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902569

Features of selective kinase inhibitors

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902569

Function and regulation of cullin-RING ubiquitin ligases

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902569

Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902569

The TOR pathway: a target for cancer therapy

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902569

Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902569

Functional discovery via a compendium of expression profiles

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902569

SCF(Met30)-mediated control of the transcriptional activator Met4 is required for the G(1)-S transition

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902569

SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902569

Therapeutic tumor-specific cell cycle block induced by methionine starvation in vivo

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902569

The Effect of Replacement of Methionine by Homocystine on Survival of Malignant and Normal Adult Mammalian Cells in Culture

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902569

Target identification using drug affinity responsive target stability (DARTS)

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902569

The yeast ubiquitin ligase SCFMet30: connecting environmental and intracellular conditions to cell division

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902569

Proteolysis-independent regulation of the transcription factor Met4 by a single Lys 48-linked ubiquitin chain.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902569

Imatinib GIST keeps finding new indications: successful treatment of dermatofibrosarcoma protuberans by targeted inhibition of the platelet-derived growth factor receptor

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902569

An integrated mass spectrometry-based proteomic approach: quantitative analysis of tandem affinity-purified in vivo cross-linked protein complexes (QTAX) to decipher the 26 S proteasome-interacting network.

17 August 2018

1 reference

A tandem affinity tag for two-step purification under fully denaturing conditions: application in ubiquitin profiling and protein complex identification combined with in vivocross-linking

21 January 2018

1 reference

A novel small-molecule inhibitor of NF-kappaB signaling

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20581845

12 December 2020

inferred from PubMed ID database lookup

Rapamycin-mediated G1 arrest involves regulation of the Cdk inhibitor Sic1 in Saccharomyces cerevisiae

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20581845

12 December 2020

inferred from PubMed ID database lookup

Composite synthetic lethal identification of membrane traffic inhibitors

1 reference

7 January 2021

Gene ontology: tool for the unification of biology

1 reference

7 January 2021

Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae

1 reference

7 January 2021

Destabilization of binding to cofactors and SCFMet30 is the rate-limiting regulatory step in degradation of polyubiquitinated Met4

1 reference

7 January 2021

A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p

1 reference

7 January 2021

In vitro reconstitution of SCF substrate ubiquitination with purified proteins

1 reference

7 January 2021

A PCR-based strategy to generate yeast strains expressing endogenous levels of amino-terminal epitope-tagged proteins

1 reference

7 January 2021

Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry

1 reference

7 January 2021

Identifiers

DOI

10.1038/NBT.1645

1 reference

15 October 2017

1 reference

15 October 2017

1 reference