(Q34947370)

5 August 2017

title

Differential regulation of dihydroceramide desaturase by palmitate versus monounsaturated fatty acids: implications for insulin resistance (English)

1 reference

5 August 2017

0 references

1 reference

1 reference

Wei Hu

1

1 reference

5 August 2017

Jessica Ross

2

1 reference

5 August 2017

Tuoyu Geng

3

1 reference

5 August 2017

Sarah E Brice

4

1 reference

5 August 2017

L Ashley Cowart

5

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5 August 2017

language of work or name

English

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publication date

15 March 2011

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Journal of Biological Chemistry

5 August 2017

published in

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5 August 2017

volume

286

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5 August 2017

issue

19

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5 August 2017

page(s)

16596-16605

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Increased mitochondrial fatty acid oxidation is sufficient to protect skeletal muscle cells from palmitate-induced apoptosis

5 August 2017

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1 reference

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8 July 2018

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Lipid-induced insulin resistance: unravelling the mechanism

8 July 2018

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8 July 2018

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8 July 2018

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Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways

8 July 2018

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8 July 2018

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Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity

8 July 2018

1 reference

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Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Principles of bioactive lipid signalling: lessons from sphingolipids

8 July 2018

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Role of insulin in the pathogenesis of free fatty acid-induced insulin resistance in skeletal muscle

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089502

Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089502

Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas

8 July 2018

1 reference

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Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089502

Ceramide-activated protein phosphatase involvement in insulin resistance via Akt, serine/arginine-rich protein 40, and ribonucleic acid splicing in L6 skeletal muscle cells

8 July 2018

1 reference

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When do Lasses (longevity assurance genes) become CerS (ceramide synthases)?: Insights into the regulation of ceramide synthesis

8 July 2018

1 reference

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Sphingosine kinase: biochemical and cellular regulation and role in disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089502

Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089502

Ceramides in insulin resistance and lipotoxicity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089502

Saturated, but not n-6 polyunsaturated, fatty acids induce insulin resistance: role of intramuscular accumulation of lipid metabolites

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089502

Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089502

Simulation and validation of modelled sphingolipid metabolism in Saccharomyces cerevisiae

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089502

How free fatty acids inhibit glucose utilization in human skeletal muscle

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089502

Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089502

Minireview: weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089502

Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089502

The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089502

Protein kinase C and lipid-induced insulin resistance in skeletal muscle.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089502

Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089502

Oleoyl-CoA is the major de novo product of stearoyl-CoA desaturase 1 gene isoform and substrate for the biosynthesis of the Harderian gland 1-alkyl-2,3-diacylglycerol

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089502

The metabolic syndrome X.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089502

Lipotoxic heart disease in obese rats: implications for human obesity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089502

Dihydroceramide desaturase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089502

Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089502

Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089502

Conversion of dihydroceramide into ceramide: involvement of a desaturase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089502

Functions of ceramide in coordinating cellular responses to stress

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089502

Sphingolipid metabolism and cell growth regulation.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089502

Role of ceramide in cellular senescence

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089502

Ceramide: a stress signal and mediator of growth suppression and apoptosis.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089502

Fatty acid-induced defects in insulin signalling, in myotubes derived from children, are related to ceramide production from palmitate rather than the accumulation of intramyocellular lipid.

8 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.186916

Oleate reverses palmitate-induced insulin resistance and inflammation in skeletal muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.186916

Oleate protects against palmitate-induced insulin resistance in L6 myotubes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.186916

A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.186916

Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.186916

Skeletal muscle insulin resistance induced by adipocyte-conditioned medium: underlying mechanisms and reversibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.186916

Adiponectin resistance precedes the accumulation of skeletal muscle lipids and insulin resistance in high-fat-fed rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.186916

Differential utilization of saturated palmitate and unsaturated oleate: evidence from cultured myotubes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.186916

Gout, Hyperlipidemia, and Diabetes Interrelationships

21 January 2018

1 reference

12 December 2020

Conversion of dihydroceramide to ceramide occurs at the cytosolic face of the endoplasmic reticulum

1 reference

12 December 2020

Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry

1 reference

12 December 2020

Key role for ceramides in mediating insulin resistance in human muscle cells

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M110.186916

1 reference

5 August 2017

1 reference

5 August 2017

1 reference