(Q40445604)

20 September 2017

title

Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling (English)

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20 September 2017

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5

Scott A Summers

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20 September 2017

Jose Antonio Chavez

1

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20 September 2017

William L Holland

series ordinal

2

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20 September 2017

Julia Bär

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3

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20 September 2017

Konrad Sandhoff

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4

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20 September 2017

language of work or name

English

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publication date

17 March 2005

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Journal of Biological Chemistry

20 September 2017

published in

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20 September 2017

volume

280

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20 September 2017

issue

20

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20 September 2017

page(s)

20148-20153

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New perspectives into the molecular pathogenesis and treatment of type 2 diabetes

20 September 2017

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Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha

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Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance

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Overexpressing human lipoprotein lipase in mouse skeletal muscle is associated with insulin resistance

21 January 2018

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Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle

21 January 2018

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Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes

21 January 2018

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Fatty acid infusion selectively impairs insulin action on Akt1 and protein kinase C lambda /zeta but not on glycogen synthase kinase-3.

21 January 2018

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Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Molecular cloning and characterization of a full-length complementary DNA encoding human acid ceramidase. Identification Of the first molecular lesion causing Farber disease

21 January 2018

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21 January 2018

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21 January 2018

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Inhibitory action of sphingosine, sphinganine and dexamethasone on glucose uptake: studies with hydrogen peroxide and phorbol ester

21 January 2018

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Sphingolipids inhibit insulin and phorbol ester stimulated uptake of 2-deoxyglucose

21 January 2018

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Effects of cell-permeable ceramides and tumor necrosis factor-alpha on insulin signaling and glucose uptake in 3T3-L1 adipocytes

21 January 2018

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A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Ceramide mediates insulin resistance by tumor necrosis factor-alpha in brown adipocytes by maintaining Akt in an inactive dephosphorylated state

21 January 2018

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Overexpression of acid ceramidase protects from tumor necrosis factor-induced cell death

21 January 2018

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Human acid ceramidase is overexpressed but not mutated in prostate cancer

21 January 2018

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Cloning and characterization of the full-length cDNA and genomic sequences encoding murine acid ceramidase

21 January 2018

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Insertional mutagenesis of the mouse acid ceramidase gene leads to early embryonic lethality in homozygotes and progressive lipid storage disease in heterozygotes

21 January 2018

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Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B.

21 January 2018

1 reference

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Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta-dependent mechanism.

21 January 2018

1 reference

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Ceramide content is increased in skeletal muscle from obese insulin-resistant humans

21 January 2018

1 reference

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Relationship between insulin sensitivity and sphingomyelin signaling pathway in human skeletal muscle

21 January 2018

1 reference

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Exercise and training effects on ceramide metabolism in human skeletal muscle.

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M412769200

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20 September 2017

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