(Q34958933)

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Heterozygous null bone morphogenetic protein receptor type 2 mutations promote SRC kinase-dependent caveolar trafficking defects and endothelial dysfunction in pulmonary arterial hypertension

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scholarly article

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Europe PubMed Central

PubMed publication ID

5 August 2017

Heterozygous null bone morphogenetic protein receptor type 2 mutations promote SRC kinase-dependent caveolar trafficking defects and endothelial dysfunction in pulmonary arterial hypertension (English)

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

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1 reference

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author name string

Allison R Prewitt

1

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Sampa Ghose

2

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Andrea L Frump

3

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Arumima Datta

4

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Eric D Austin

5

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Anne K Kenworthy

6

1 reference

Europe PubMed Central

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5 August 2017

Mark P de Caestecker

7

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Europe PubMed Central

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5 August 2017

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publication date

19 November 2014

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Europe PubMed Central

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5 August 2017

Journal of Biological Chemistry

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Europe PubMed Central

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5 August 2017

290

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Europe PubMed Central

PubMed publication ID

5 August 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

960-971

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4294523/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294523

8 July 2018

Overexpression of caveolin-1 is sufficient to phenocopy the behavior of a disease-associated mutant

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294523

8 July 2018

Pulmonary vascular disease in mice xenografted with human BM progenitors from patients with pulmonary arterial hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294523

8 July 2018

Modern age pathology of pulmonary arterial hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294523

8 July 2018

Whole exome sequencing to identify a novel gene (caveolin-1) associated with human pulmonary arterial hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294523

8 July 2018

Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294523

8 July 2018

Caveolae, caveolins, cavins, and endothelial cell function: new insights.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294523

8 July 2018

Attenuation of leukocyte recruitment via CXCR1/2 inhibition stops the progression of PAH in mice with genetic ablation of endothelial BMPR-II.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294523

8 July 2018

Role of caveolin-1 in the regulation of pulmonary endothelial permeability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294523

8 July 2018

Role for miR-204 in human pulmonary arterial hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294523

8 July 2018

BMP signaling in vascular development and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294523

8 July 2018

Bmp2 and Bmp4 exert opposing effects in hypoxic pulmonary hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294523

8 July 2018

Src kinases as therapeutic targets for cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294523

8 July 2018

Persistent eNOS activation secondary to caveolin-1 deficiency induces pulmonary hypertension in mice and humans through PKG nitration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294523

8 July 2018

Caveolae-mediated internalization of occludin and claudin-5 during CCL2-induced tight junction remodeling in brain endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294523

8 July 2018

Humanized large-scale expanded endothelial colony-forming cells function in vitro and in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294523

8 July 2018

The biology of caveolae: achievements and perspectives.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294523

8 July 2018

Regulation of transendothelial permeability by Src kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294523

8 July 2018

Genetic ablation of the BMPR2 gene in pulmonary endothelium is sufficient to predispose to pulmonary arterial hypertension.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294523

8 July 2018

SKI-606 (bosutinib), a novel Src kinase inhibitor, suppresses migration and invasion of human breast cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294523

8 July 2018

Use of dynasore, the small molecule inhibitor of dynamin, in the regulation of endocytosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294523

8 July 2018

Increased pulmonary vascular resistance and defective pulmonary artery filling in caveolin-1-/- mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294523

8 July 2018

Dynasore, a cell-permeable inhibitor of dynamin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294523

8 July 2018

Downregulation of type II bone morphogenetic protein receptor in hypoxic pulmonary hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294523

8 July 2018

The BMP type II receptor is located in lipid rafts, including caveolae, of pulmonary endothelium in vivo and in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294523

8 July 2018

The double regulation of endothelial nitric oxide synthase by caveolae and caveolin: a paradox solved through the study of angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294523

8 July 2018

Actin depolymerization disrupts tight junctions via caveolae-mediated endocytosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294523

8 July 2018

Role of Src-induced dynamin-2 phosphorylation in caveolae-mediated endocytosis in endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294523

8 July 2018

Caveolin regulation of endothelial function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294523

8 July 2018

Inflammation in pulmonary arterial hypertension.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294523

8 July 2018

Vesicle formation and trafficking in endothelial cells and regulation of endothelial barrier function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294523

8 July 2018

Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294523

8 July 2018

BMP type II receptor is required for gastrulation and early development of mouse embryos

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294523

8 July 2018

Dynamin-mediated internalization of caveolae.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294523

8 July 2018

Low temperature reversibly inhibits transport from tubular endosomes to a perinuclear, acidic compartment in African trypanosomes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294523

8 July 2018

Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294523

8 July 2018

Survival in patients with idiopathic, familial, and anorexigen-associated pulmonary arterial hypertension in the modern management era.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.591057

21 January 2018

Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.591057

21 January 2018

Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.591057

21 January 2018

Bone morphogenetic protein receptor II regulates pulmonary artery endothelial cell barrier function

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https://api.crossref.org/works/10.1074%2FJBC.M114.591057

21 January 2018

Immune and inflammatory cell involvement in the pathology of idiopathic pulmonary arterial hypertension.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.591057

21 January 2018

Increased smooth muscle cell expression of caveolin-1 and caveolae contribute to the pathophysiology of idiopathic pulmonary arterial hypertension.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.591057

21 January 2018

Generation of a floxed allele of the mouse BMP type II receptor gene.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.591057

21 January 2018

Bone morphogenetic protein 4 promotes pulmonary vascular remodeling in hypoxic pulmonary hypertension.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.591057

21 January 2018

Bone morphogenetic protein receptor type II C-terminus interacts with c-Src: implication for a role in pulmonary arterial hypertension

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.591057

21 January 2018

Disruption of endothelial-cell caveolin-1alpha/raft scaffolding during development of monocrotaline-induced pulmonary hypertension

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.591057

21 January 2018

Dehydroepiandrosterone inhibits the Src/STAT3 constitutive activation in pulmonary arterial hypertension.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.591057

21 January 2018

Increased susceptibility to hypoxic pulmonary hypertension in Bmpr2 mutant mice is associated with endothelial dysfunction in the pulmonary vasculature

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.591057

21 January 2018

Impaired transforming growth factor-beta signaling in idiopathic pulmonary arterial hypertension

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https://pubmed.ncbi.nlm.nih.gov/25411245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/25411245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interrelations/cross talk between transcellular transport function and paracellular tight junctional properties in lung epithelial and endothelial barriers

1 reference

https://pubmed.ncbi.nlm.nih.gov/25411245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation and characterization of endothelial progenitor cells from human blood

1 reference

https://pubmed.ncbi.nlm.nih.gov/25411245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M114.591057

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

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