(Q24656966)

22 June 2017

title

SKI-606 (bosutinib), a novel Src kinase inhibitor, suppresses migration and invasion of human breast cancer cells (English)

1 reference

22 June 2017

1 reference

ChEBI release 2020-05-28

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1

Adina Vultur

1 reference

22 June 2017

Ralf Buettner

2

1 reference

22 June 2017

Claudia Kowolik

3

1 reference

22 June 2017

Wei Liang

4

1 reference

22 June 2017

David Smith

5

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22 June 2017

Frank Boschelli

6

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22 June 2017

Richard Jove

7

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22 June 2017

language of work or name

English

0 references

publication date

1 May 2008

1 reference

Molecular Cancer Therapeutics

22 June 2017

published in

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22 June 2017

volume

7

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22 June 2017

issue

5

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22 June 2017

page(s)

1185-1194

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describes a project that uses

22 June 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2794837/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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7 April 2017

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Identification of protein-tyrosine phosphatase 1B as the major tyrosine phosphatase activity capable of dephosphorylating and activating c-Src in several human breast cancer cell lines

7 April 2017

1 reference

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Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src

7 April 2017

1 reference

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Identification of Src-specific phosphorylation site on focal adhesion kinase: dissection of the role of Src SH2 and catalytic functions and their consequences for tumor cell behavior

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794837

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7 April 2017

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Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures

7 April 2017

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7 April 2017

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Src family kinases are required for integrin but not PDGFR signal transduction.

7 April 2017

1 reference

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A Src/Abl kinase inhibitor, SKI-606, blocks breast cancer invasion, growth, and metastasis in vitro and in vivo

10 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794837

Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival

28 September 2017

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Role of c-Src in human MCF7 breast cancer cell tumorigenesis

28 September 2017

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Inhibition of protein kinase c-Src reduces the incidence of breast cancer metastases and increases survival in mice: implications for therapy

28 September 2017

1 reference

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Inhibition of SRC expression and activity inhibits tumor progression and metastasis of human pancreatic adenocarcinoma cells in an orthotopic nude mouse model

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794837

SKI-606 decreases growth and motility of colorectal cancer cells by preventing pp60(c-Src)-dependent tyrosine phosphorylation of beta-catenin and its nuclear signaling

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794837

Action of the Src family kinase inhibitor, dasatinib (BMS-354825), on human prostate cancer cells

28 September 2017

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Dasatinib (BMS-354825) tyrosine kinase inhibitor suppresses invasion and induces cell cycle arrest and apoptosis of head and neck squamous cell carcinoma and non-small cell lung cancer cells

28 September 2017

1 reference

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Specific induction of pp125 focal adhesion kinase in human breast cancer

28 September 2017

1 reference

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Stat3 is required for full neoplastic transformation by the Simian Virus 40 large tumor antigen

28 September 2017

1 reference

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c-Src and cooperating partners in human cancer

28 September 2017

1 reference

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Coupling of RAFTK/Pyk2 kinase with c-Abl and their role in the migration of breast cancer cells

28 September 2017

1 reference

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Src in cancer: deregulation and consequences for cell behaviour

28 September 2017

1 reference

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Src family kinases and HER2 interactions in human breast cancer cell growth and survival

28 September 2017

1 reference

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Neoplastic transformation assays.

28 September 2017

1 reference

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c-Src kinase activity is required for hepatocyte growth factor-induced motility and anchorage-independent growth of mammary carcinoma cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794837

c-Src protein expression is increased in human breast cancer. An immunohistochemical and biochemical analysis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794837

Characterization of protein tyrosine kinases from human breast cancer: involvement of the c-src oncogene product.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794837

The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794837

Activation of stat3 in primary tumors from high-risk breast cancer patients is associated with elevated levels of activated SRC and survivin expression

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794837

Src and FAK signalling controls adhesion fate and the epithelial-to-mesenchymal transition

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794837

SKI-606, a Src/Abl inhibitor with in vivo activity in colon tumor xenograft models

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794837

Proline-rich tyrosine kinase 2 (Pyk2) mediates vascular endothelial-cadherin-based cell-cell adhesion by regulating beta-catenin tyrosine phosphorylation

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794837

ErbB2 promotes Src synthesis and stability: novel mechanisms of Src activation that confer breast cancer metastasis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794837

Activated signal transducer and activator of transcription (STAT) 3: localization in focal adhesions and function in ovarian cancer cell motility

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794837

SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794837

Analysis of pp60c-src protein kinase activity in human tumor cell lines and tissues

28 November 2018

1 reference

12 December 2020

Immunohistochemical analyses of focal adhesion kinase expression in benign and malignant human breast and colon tissues: correlation with preinvasive and invasive phenotypes

1 reference

12 December 2020

Elevated activity and expression of Src-family kinases in human breast carcinoma tissue versus matched non-tumor tissue

1 reference

12 December 2020

Long-term follow-up of patients with complete remission following combination chemotherapy for metastatic breast cancer

1 reference

12 December 2020

10.1158/1535-7163.MCT-08-0126

Identifiers

DOI

1 reference

22 June 2017

0 references

1 reference