(Q34979594)

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Structure-based design, synthesis and biological evaluation of novel β-secretase inhibitors containing a pyrazole or thiazole moiety as the P3 ligand

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Europe PubMed Central

PubMed publication ID

5 August 2017

Structure-based design, synthesis and biological evaluation of novel β-secretase inhibitors containing a pyrazole or thiazole moiety as the P3 ligand (English)

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Europe PubMed Central

PubMed publication ID

5 August 2017

Andrew D. Mesecar

10

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25537272%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

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Arun K Ghosh

1

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12 June 2020

Margherita Brindisi

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25537272%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Yu-Chen Yen

3

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12 June 2020

Xiaoming Xu

4

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12 June 2020

Xiangping Huang

5

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12 June 2020

Thippeswamy Devasamudram

6

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12 June 2020

Geoffrey Bilcer

7

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12 June 2020

Hui Lei

8

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12 June 2020

Gerald Koelsch

9

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12 June 2020

Jordan Tang

11

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12 June 2020

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publication date

6 December 2014

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5 August 2017

Bioorganic & Medicinal Chemistry Letters

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12 June 2020

25

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12 June 2020

3

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12 June 2020

668-672

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12 June 2020

BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297543

8 July 2018

A cellular model of amyloid precursor protein processing and amyloid-β peptide production

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297543

8 July 2018

Developing β-secretase inhibitors for treatment of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297543

8 July 2018

BACE: Therapeutic target and potential biomarker for Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297543

8 July 2018

The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297543

8 July 2018

CHARMM: the biomolecular simulation program

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297543

8 July 2018

beta-Secretase as a therapeutic target for Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297543

8 July 2018

Cathepsin D--many functions of one aspartic protease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297543

8 July 2018

Design, synthesis, and X-ray structure of potent memapsin 2 (beta-secretase) inhibitors with isophthalamide derivatives as the P2-P3-ligands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297543

8 July 2018

Design, synthesis and X-ray structure of protein-ligand complexes: important insight into selectivity of memapsin 2 (beta-secretase) inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297543

8 July 2018

Beta-secretase inhibition for the treatment of Alzheimer's disease--promise and challenge

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297543

8 July 2018

Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297543

8 July 2018

The disulphide bonds in the catalytic domain of BACE are critical but not essential for amyloid precursor protein processing activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297543

8 July 2018

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297543

8 July 2018

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297543

8 July 2018

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297543

8 July 2018

Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297543

8 July 2018

Computational prediction of blood-brain barrier permeability using decision tree induction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297543

26 October 2018

Structure-based design: potent inhibitors of human brain memapsin 2 (beta-secretase).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297543

26 October 2018

Proteolytic activation of recombinant pro-memapsin 2 (pro-beta-secretase) studied with new fluorogenic substrates

1 reference

https://pubmed.ncbi.nlm.nih.gov/25537272

12 December 2020

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Synthesis of Enantiomerically Pure Anti-Aldols: A Highly Stereoselective Ester-Derived Titanium Enolate Aldol Reaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/25537272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

cis-1-Aminoindan-2-ol in Asymmetric Syntheses.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25537272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.BMCL.2014.11.087

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25537272%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25537272%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25537272%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

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