(Q45076681)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22941223%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

title

Computational prediction of blood-brain barrier permeability using decision tree induction (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22941223%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

1 reference

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22941223%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Felix Hammann

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22941223%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

author name string

Claudia Suenderhauf

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22941223%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

language of work or name

English

0 references

publication date

31 August 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22941223%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22941223%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

volume

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22941223%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

issue

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22941223%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

page(s)

10429-10445

1 reference

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Creative Commons Attribution 4.0 International

12 February 2020

copyright license

start time

31 August 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Comparison of in vitro and in vivo models of drug transcytosis through the blood-brain barrier

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12 December 2020

Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. 2. Prediction of blood-brain barrier penetration

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12 December 2020

Decision tree models for data mining in hit discovery

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12 December 2020

Capillary depletion method for quantification of blood-brain barrier transport of circulating peptides and plasma proteins

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12 December 2020

Identifying P-glycoprotein substrates using a support vector machine optimized by a particle swarm

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12 December 2020

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs

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12 December 2020

Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs.

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12 December 2020

Ionization-specific prediction of blood-brain permeability

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12 December 2020

Inspiration for optimization from social insect behaviour

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In silico predictions of blood-brain barrier penetration: considerations to "keep in mind".

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12 December 2020

The blood-brain barrier: bottleneck in brain drug development

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12 December 2020

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12 December 2020

Brain uptake of nonsteroidal anti-inflammatory drugs: ibuprofen, flurbiprofen, and indomethacin.

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12 December 2020

Qualitative prediction of blood-brain barrier permeability on a large and refined dataset

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12 December 2020

Structure-activity relationship: analyses of p-glycoprotein substrates and inhibitors

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12 December 2020

The pharmacokinetic inter-relationship of tiagabine in blood, cerebrospinal fluid and brain extracellular fluid (frontal cortex and hippocampus).

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12 December 2020

Blood-brain barrier permeation: molecular parameters governing passive diffusion

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12 December 2020

Development of decision tree models for substrates, inhibitors, and inducers of p-glycoprotein

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12 December 2020

Astrocyte-endothelial interactions at the blood-brain barrier

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12 December 2020

CNS drug design based on principles of blood-brain barrier transport

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12 December 2020

Best Practices for QSAR Model Development, Validation, and Exploitation

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12 December 2020

Index for rating diagnostic tests

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12 December 2020

Kinetics of amino acid transport at the blood-brain barrier studied using an in situ brain perfusion technique.

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12 December 2020

P-glycoprotein deficient mouse in situ blood-brain barrier permeability and its prediction using an in combo PAMPA model

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12 December 2020

Phenylalanine transport across the blood-brain barrier as studied with the in situ brain perfusion technique

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12 December 2020

Comparison of blood-brain barrier permeability in mice and rats using in situ brain perfusion technique

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12 December 2020

The Chemistry Development Kit (CDK): an open-source Java library for Chemo- and Bioinformatics

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uses method in cited work

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12 December 2020

CiteULike CiTO annotations

Central nervous system drug disposition: the relationship between in situ brain permeability and brain free fraction

2022

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12 December 2020

Polar molecular surface as a dominating determinant for oral absorption and brain penetration of drugs

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12 December 2020

Localisation of breast cancer resistance protein in microvessel endothelium of human brain

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12 December 2020

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites

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12 December 2020

Prediction of adverse drug reactions using decision tree modeling

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12 December 2020

Estimation of blood-brain barrier crossing of drugs using molecular size and shape, and H-bonding descriptors.

1 reference

12 December 2020

Stereoselective and species‐dependent kinetics of reboxetine in mouse and rat

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12 December 2020

Facilitated transport of melphalan at the rat blood-brain barrier by the large neutral amino acid carrier system

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12 December 2020

A binary ant colony optimization classifier for molecular activities.

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12 December 2020

ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood-brain barrier.

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12 December 2020

Regulation of BCRP (ABCG2) and P-glycoprotein (ABCB1) by cytokines in a model of the human blood-brain barrier

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12 December 2020

An in situ brain perfusion technique to study cerebrovascular transport in the rat.

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12 December 2020

Endocytosis and transcytosis of an immunoliposome-based brain drug delivery system.

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12 December 2020

Development of a computational approach to predict blood-brain barrier permeability

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12 December 2020

Drug interactions with lipid membranes

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12 December 2020

Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery

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12 December 2020

Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview.

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12 December 2020

Clinical relevance of P-glycoprotein in drug therapy

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12 December 2020

Flavonoid permeability across an in situ model of the blood-brain barrier

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12 December 2020

Combinatorial QSAR modeling of human intestinal absorption

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12 December 2020

Computational approaches to the prediction of the blood-brain distribution

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12 December 2020

Cerebral uptake of mefloquine enantiomers in fatal cerebral malaria.

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12 December 2020

Altered pharmacokinetics of vinblastine in Mdr1a P-glycoprotein-deficient Mice

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12 December 2020

Classification analysis of P-glycoprotein substrate specificity

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12 December 2020

Ionization-specific QSAR models of blood-brain penetration of drugs.

1 reference

12 December 2020

Determination of lipophilicity and its use as a predictor of blood-brain barrier penetration of molecular imaging agents

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12 December 2020

Open Babel: An open chemical toolbox

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12 December 2020

Limited distribution of new quinolone antibacterial agents into brain caused by multiple efflux transporters at the blood-brain barrier.

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12 December 2020

Molecular factors influencing drug transfer across the blood-brain barrier.

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12 December 2020

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

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12 December 2020

Correlation of blood-brain penetration using structural descriptors.

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12 December 2020

The factors that influence permeation across the blood-brain barrier.

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12 December 2020

In silico prediction of blood–brain barrier permeation

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12 December 2020

Log(BB), PS products and in silico models of drug brain penetration

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12 December 2020

Correlation and prediction of a large blood-brain distribution data set--an LFER study

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12 December 2020

Development of an in situ mouse brain perfusion model and its application to mdr1a P-glycoprotein-deficient mice

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12 December 2020

Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability

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12 December 2020

Prediction and mechanistic interpretation of human oral drug absorption using MI-QSAR analysis

1 reference

12 December 2020

In silico prediction of brain and CSF permeation of small molecules using PLS regression models

1 reference

12 December 2020

10.3390/MOLECULES170910429

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22941223%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22941223%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

PubMed publication ID

22941223

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22941223%20AND%20SRC:MED&resulttype=core&format=json