(Q35620664)

9 August 2017

1 reference

title

Clinical relevance of P-glycoprotein in drug therapy (English)

1 reference

9 August 2017

Jiunn H Lin

1

1 reference

PubMed ID

14705869

9 August 2017

Masayo Yamazaki

series ordinal

2

1 reference

PubMed ID

14705869

9 August 2017

language of work or name

English

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publication date

1 November 2003

1 reference

9 August 2017

Drug Metabolism Reviews

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9 August 2017

35

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9 August 2017

417-454

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9 August 2017

4

1 reference

The Bcl-2 protein family: arbiters of cell survival

9 August 2017

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Death receptors: signaling and modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Cerebrospinal fluid production is normal in Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Evidence for a polarized efflux system in CACO-2 cells capable of modulating cyclosporin A transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Inhibitors of multidrug resistance to antitumor agents (MDR).

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Rifampin drastically reduces plasma concentrations and effects of oral midazolam.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

The cell biology of multiple drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Mechanisms of multidrug resistance in human tumor cells. The roles of P-glycoprotein, DNA topoisomerase II, and other factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

The drug efflux-metabolism alliance: biochemical aspects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Techniques for plasma protein binding of demethylchlorimipramine

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

P-glycoprotein limits the brain penetration of nonsedating but not sedating H1-antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Hydrogen bonding potential as a determinant of the in vitro and in situ blood-brain barrier permeability of peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Affinity for the P-glycoprotein efflux pump at the blood-brain barrier may explain the lack of CNS side-effects of modern antihistamines

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Apparent lack of Mrp1-mediated efflux at the luminal side of mouse blood-brain barrier endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Considerations in the design and development of transport inhibitors as adjuncts to drug therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

P-glycoprotein-mediated intestinal and biliary digoxin transport in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Expression of the multidrug resistance-associated protein (MRP) gene in colorectal carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Paclitaxel-resistant human ovarian cancer cells have mutant beta-tubulins that exhibit impaired paclitaxel-driven polymerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Multidrug resistance in cancer: role of ATP-dependent transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Intestinal secretion of intravenous talinolol is inhibited by luminal R-verapamil

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Steady-state pharmacokinetics of indinavir in cerebrospinal fluid and plasma among adults with human immunodeficiency virus type 1 infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Effects of ritonavir on indinavir pharmacokinetics in cerebrospinal fluid and plasma

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Altered expression of M beta 2, the class II beta-tubulin isotype, in a murine J774.2 cell line with a high level of taxol resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Complete in vivo reversal of P-glycoprotein pump function in the blood-brain barrier visualized with positron emission tomography

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Gene amplification in a leukemic patient treated with methotrexate

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Drug absorption limited by P-glycoprotein-mediated secretory drug transport in human intestinal epithelial Caco-2 cell layers

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

MDCK (Madin-Darby canine kidney) cells: A tool for membrane permeability screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Clinical pharmacokinetics and pharmacodynamics of cholinesterase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

High levels of P-glycoprotein detected in isolated brain capillaries.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

A morphometric study on the development of the lateral ventricle choroid plexus, choroid plexus capillaries and ventricular ependyma in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Effect of ketoconazole on ritonavir and saquinavir concentrations in plasma and cerebrospinal fluid from patients infected with human immunodeficiency virus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Efflux transport systems for drugs at the blood-brain barrier and blood-cerebrospinal fluid barrier (Part 1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Efflux transport systems for drugs at the blood-brain barrier and blood-cerebrospinal fluid barrier (Part 2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Protein binding as a primary determinant of the clinical pharmacokinetic properties of non-steroidal anti-inflammatory drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Role of P-glycoprotein in pharmacokinetics: clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Uncoupling ceramide glycosylation by transfection of glucosylceramide synthase antisense reverses adriamycin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Alteration of etoposide pharmacokinetics and pharmacodynamics by cyclosporine in a phase I trial to modulate multidrug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC833

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Verapamil. An updated review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

The prognostic significance of expression of the multidrug resistance-associated protein (MRP) in primary breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Expression of the multidrug resistance protein (MRP) in squamous cell carcinoma of the oesophagus and response to pre-operative chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Midazolam should be avoided in patients receiving the systemic antimycotics ketoconazole or itraconazole.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Verapamil and adriamycin in the treatment of drug-resistant ovarian cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Transport of protein-bound hormones into tissues in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Role of P-glycoprotein on the CNS disposition of amprenavir (141W94), an HIV protease inhibitor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Phase I and pharmacokinetic study of paclitaxel in combination with biricodar, a novel agent that reverses multidrug resistance conferred by overexpression of both MDR1 and MRP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Effect of plasma protein binding on in vivo activity and brain penetration of glycine/NMDA receptor antagonists.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Increased drug delivery to the brain by P-glycoprotein inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Drug efflux transporters in the CNS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Transporter-mediated permeation of drugs across the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Cytologic evidence for gene amplification in methotrexate-resistant cells obtained from a patient with ovarian adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Increased accumulation of doxorubicin and doxorubicinol in cardiac tissue of mice lacking mdr1a P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Development of multidrug-resistance convertors: sense or nonsense?

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Dipyridamole enhances digoxin bioavailability via P-glycoprotein inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

MDR1 and MRP expression in chronic B-cell lymphoproliferative disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Evidence for intestinal secretion as an additional clearance pathway of talinolol enantiomers: concentration- and dose-dependent absorption in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

P-glycoprotein-dependent disposition kinetics of tacrolimus: studies in mdr1a knockout mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

Ceramide glycosylation potentiates cellular multidrug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026871

21 January 2018

Identifiers

DOI

10.1081/DMR-120026871

1 reference

9 August 2017

1 reference

PubMed ID

14705869