(Q47326688)

14 January 2018

title

Classification analysis of P-glycoprotein substrate specificity (English)

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14 January 2018

author name string

Remigijus Didziapetris

1

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14 January 2018

Pranas Japertas

2

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14 January 2018

Alex Avdeef

3

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14 January 2018

Alanas Petrauskas

4

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14 January 2018

publication date

1 August 2003

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14 January 2018

Journal of Drug Targeting

published in

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14 January 2018

volume

11

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14 January 2018

issue

7

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14 January 2018

page(s)

391-406

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14 January 2018

Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein

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Many P-glycoprotein substrates do not inhibit the transport process across cell membranes

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Affinity for the P-glycoprotein efflux pump at the blood-brain barrier may explain the lack of CNS side-effects of modern antihistamines

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Screening of multidrug-resistance sensitive drugs by in situ brain perfusion in P-glycoprotein-deficient mice

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Unmasking the dynamic interplay between intestinal P-glycoprotein and CYP3A4.

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Effect of mdr1a P-glycoprotein gene disruption, gender, and substrate concentration on brain uptake of selected compounds

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Distribution of STI-571 to the brain is limited by P-glycoprotein-mediated efflux

21 January 2018

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Mappain, a new cytotoxic prenylated stilbene from Macaranga mappa.

21 January 2018

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Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein

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Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs.

21 January 2018

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Role of P-glycoprotein-mediated secretion in absorptive drug permeability: An approach using passive membrane permeability and affinity to P-glycoprotein

21 January 2018

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Structure-activity relationship studies on benzofuran analogs of propafenone-type modulators of tumor cell multidrug resistance.

21 January 2018

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Application of three-dimensional quantitative structure-activity relationships of P-glycoprotein inhibitors and substrates

21 January 2018

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Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein

21 January 2018

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Evaluation of a vincristine resistant Caco-2 cell line for use in a calcein AM extrusion screening assay for P-glycoprotein interaction

21 January 2018

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Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties

21 January 2018

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Kinetic analysis of calcein and calcein-acetoxymethylester efflux mediated by the multidrug resistance protein and P-glycoprotein

21 January 2018

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Drug transport proteins in the liver

21 January 2018

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Analysis of the tangled relationships between P-glycoprotein-mediated multidrug resistance and the lipid phase of the cell membrane

21 January 2018

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https://api.crossref.org/works/10.1080%2F10611860310001648248

Characterization of two pharmacophores on the multidrug transporter P-glycoprotein

21 January 2018

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https://api.crossref.org/works/10.1080%2F10611860310001648248

In vitro blood-brain barrier permeability of nevirapine compared to other HIV antiretroviral agents

21 January 2018

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https://api.crossref.org/works/10.1080%2F10611860310001648248

Multidrug resistance in cancer: role of ATP-dependent transporters

21 January 2018

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https://api.crossref.org/works/10.1080%2F10611860310001648248

Antitumor activity of troxacitabine (Troxatyl) against anthracycline-resistant human xenografts

21 January 2018

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https://api.crossref.org/works/10.1080%2F10611860310001648248

Lipophilic cations: a group of model substrates for the multidrug-resistance transporter.

21 January 2018

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https://api.crossref.org/works/10.1080%2F10611860310001648248

P-glycoprotein efflux pump expression and activity in Calu-3 cells

21 January 2018

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https://api.crossref.org/works/10.1080%2F10611860310001648248

Chem-bioinformatics and QSAR: a review of QSAR lacking positive hydrophobic terms

21 January 2018

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https://api.crossref.org/works/10.1080%2F10611860310001648248

Synthesis and in Vitro Multidrug Resistance Modulating Activity of a Series of Dihydrobenzopyrans and Tetrahydroquinolines†

21 January 2018

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https://api.crossref.org/works/10.1080%2F10611860310001648248

Drug absorption limited by P-glycoprotein-mediated secretory drug transport in human intestinal epithelial Caco-2 cell layers

21 January 2018

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https://api.crossref.org/works/10.1080%2F10611860310001648248

Fragmental Methods in the Analysis of Biological Activities of Diverse Compound Sets

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Role of blood-brain barrier P-glycoprotein in limiting brain accumulation and sedative side-effects of asimadoline, a peripherally acting analgaesic drug

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Transport of celiprolol across human intestinal epithelial (Caco-2) cells: mediation of secretion by multiple transporters including P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Resistance to tetracycline, a hydrophilic antibiotic, is mediated by P-glycoprotein in human multidrug-resistant cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Pharmaceutical profiling in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Drugs as P-glycoprotein substrates, inhibitors, and inducers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors

21 January 2018

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https://api.crossref.org/works/10.1080%2F10611860310001648248

Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein.

21 January 2018

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https://api.crossref.org/works/10.1080%2F10611860310001648248

Pharmacokinetics and interactions of a novel antagonist of chemokine receptor 5 (CCR5) with ritonavir in rats and monkeys: role of CYP3A and P-glycoprotein

21 January 2018

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https://api.crossref.org/works/10.1080%2F10611860310001648248

Structure-permeation relations of met-enkephalin peptide analogues on absorption and secretion mechanisms in Caco-2 monolayers

21 January 2018

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https://api.crossref.org/works/10.1080%2F10611860310001648248

In vitro and in vivo investigations on fluoroquinolones; effects of the P-glycoprotein efflux transporter on brain distribution of sparfloxacin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

P-glycoprotein deficiency in a subpopulation of CF-1 mice enhances avermectin-induced neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Secretory transport of ranitidine and famotidine across Caco-2 cell monolayers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Altered drug disposition of the platelet activating factor antagonist apafant in mdr1a knockout mice

21 January 2018

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https://api.crossref.org/works/10.1080%2F10611860310001648248

Drug-drug interaction mediated by inhibition and induction of P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Role of P-glycoprotein in pharmacokinetics: clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

The vinblastine binding site adopts high- and low-affinity conformations during a transport cycle of P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Contribution of P-glycoprotein to bunitrolol efflux across blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Computational approaches to the prediction of the blood-brain distribution

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Prediction of polar surface area and drug transport processes using simple parameters and PLS statistics

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Pharmacophore model of drugs involved in P-glycoprotein multidrug resistance: explanation of structural variety (hypothesis).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Multidrug resistance transporter P-glycoprotein has distinct but interacting binding sites for cytotoxic drugs and reversing agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

P-glycoprotein-mediated transport of digitoxin, alpha-methyldigoxin and beta-acetyldigoxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Interaction of omeprazole, lansoprazole and pantoprazole with P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

A computational ensemble pharmacophore model for identifying substrates of P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Differences in the absorption, metabolism and biliary excretion of a diastereomeric pair of alphavbeta3-antagonists in rat: limited role of P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Structure of the multidrug resistance P-glycoprotein to 2.5 nm resolution determined by electron microscopy and image analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Three-dimensional structures of the mammalian multidrug resistance P-glycoprotein demonstrate major conformational changes in the transmembrane domains upon nucleotide binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

P-glycoprotein-mediated transcellular transport of MDR-reversing agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Active efflux of the 5-HT(1A) receptor agonist flesinoxan via P-glycoprotein at the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

P-Glycoprotein, a gatekeeper in the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Structure-activity relationship studies of propafenone analogs based on P-glycoprotein ATPase activity measurements.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

A general pattern for substrate recognition by P-glycoprotein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Structure-activity relationship of P-glycoprotein substrates and modifiers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Structure-activity relationships of antineoplastic agents in multidrug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Positively cooperative sites for drug transport by P-glycoprotein with distinct drug specificities

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Fumonisin toxicity in a transgenic mouse model lacking the mdr1a/1b P-glycoprotein genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

The P-glycoprotein efflux pump: how does it transport drugs?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Synthetic hydrophobic peptides are substrates for P-glycoprotein and stimulate drug transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

P-glycoprotein-mediated efflux of antiepileptic drugs: preliminary studies in mdr1a knockout mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

P-glycoprotein interactions of nefazodone and trazodone in cell culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Differential modulation of P-glycoprotein expression and activity by non-nucleoside HIV-1 reverse transcriptase inhibitors in cell culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Progress in understanding the structure-activity relationships of P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Can the enhanced renal clearance of antibiotics in cystic fibrosis patients be explained by P-glycoprotein transport?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

The novel anticancer drug KRN5500 interacts with, but is hardly transported by, human P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Cytotoxic effects of 27 anticancer drugs in HeLa and MDR1-overexpressing derivative cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Blood-brain barrier transport of H1-antagonist ebastine and its metabolite carebastine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Characterization of the efflux transporter(s) responsible for restricting intestinal mucosa permeation of the coumarinic acid-based cyclic prodrug of the opioid peptide DADLE.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Active secretion of drugs from the small intestinal epithelium in rats by P-glycoprotein functioning as an absorption barrier

21 January 2018

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https://api.crossref.org/works/10.1080%2F10611860310001648248

Opiate-induced analgesia is increased and prolonged in mice lacking P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Transport of new non-cross-resistant antitumor compounds of the benzoperimidine family in multidrug resistant cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

A combined Hansch/Free-Wilson approach as predictive tool in QSAR studies on propafenone-type modulators of multidrug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Structure-activity relationship of verapamil analogs and reversal of multidrug resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Chinese hamster ovary cells resistant to okadaic acid express a multidrug resistant phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Midazolam exhibits characteristics of a highly permeable P-glycoprotein substrate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Penetration of amitriptyline, but not of fluoxetine, into brain is enhanced in mice with blood-brain barrier deficiency due to mdr1a P-glycoprotein gene disruption

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Molecular properties that influence the oral bioavailability of drug candidates

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Active secretion and enterocytic drug metabolism barriers to drug absorption

21 January 2018

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https://api.crossref.org/works/10.1080%2F10611860310001648248

Intestinal drug efflux: formulation and food effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Interaction of morphine, fentanyl, sufentanil, alfentanil, and loperamide with the efflux drug transporter P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Property-based design: optimization of drug absorption and pharmacokinetics

21 January 2018

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https://api.crossref.org/works/10.1080%2F10611860310001648248

ADMET in silico modelling: towards prediction paradise?

21 January 2018

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https://api.crossref.org/works/10.1080%2F10611860310001648248

The relative importance of passive and P-glycoprotein mediated anthracycline efflux from multidrug-resistant cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Polarized transport of docetaxel and vinblastine mediated by P-glycoprotein in human intestinal epithelial cell monolayers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Contribution of P-glycoprotein to efflux of ramosetron, a 5-HT3 receptor antagonist, across the blood-brain barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Interaction of cytochrome P450 3A inhibitors with P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Efflux transporters of the human placenta

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

The contribution of P-glycoprotein to pharmacokinetic drug-drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Structural Basis of Multiple Drug-Binding Capacity of the AcrB Multidrug Efflux Pump

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

In vitro and in vivo models for assessing drug efflux transporter activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Evaluation of human intestinal absorption data and subsequent derivation of a quantitative structure-activity relationship (QSAR) with the Abraham descriptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

Progress in toxinformatics: the challenge of predicting acute toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10611860310001648248

10.1080/10611860310001648248

21 January 2018

Identifiers

DOI

1 reference

14 January 2018

1 reference

14 January 2018