(Q48406304)

11 February 2018

title

Drug-drug interaction mediated by inhibition and induction of P-glycoprotein (English)

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11 February 2018

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Jiunn H Lin

1

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11 February 2018

language of work or name

English

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publication date

1 January 2003

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11 February 2018

Advanced Drug Delivery Reviews

published in

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11 February 2018

volume

55

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11 February 2018

issue

1

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11 February 2018

page(s)

53-81

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11 February 2018

Biochemistry of multidrug resistance mediated by the multidrug transporter

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Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

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Drug absorption limited by P-glycoprotein-mediated secretory drug transport in human intestinal epithelial Caco-2 cell layers

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7 January 2021

Evidence for a polarized efflux system in CACO-2 cells capable of modulating cyclosporin A transport

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7 January 2021

Evidence for a polarized efflux system for peptides in the apical membrane of Caco-2 cells

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7 January 2021

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

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7 January 2021

Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr 1a P-glycoprotein

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7 January 2021

Intestinal secretion of intravenous talinolol is inhibited by luminal R-verapamil

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7 January 2021

Coadministration of cyclosporine strongly enhances the oral bioavailability of docetaxel

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7 January 2021

Differential inhibition by cyclosporins of primary-active ATP-dependent transporters in the hepatocyte canalicular membrane

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7 January 2021

Relevance of p-glycoprotein for the enteral absorption of cyclosporin A: in vitro-in vivo correlation

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7 January 2021

Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine*

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7 January 2021

Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

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7 January 2021

The turnover of the epithelium of the small intestine

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7 January 2021

Transporters on demand: intrahepatic pools of canalicular ATP binding cassette transporters in rat liver

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7 January 2021

Expression of a multidrug-resistance gene in human tumors and tissues

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7 January 2021

Tissue distribution and chemical induction of multiple drug resistance genes in rats

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7 January 2021

Direct demonstration of small intestinal secretion and site-dependent absorption of the beta-blocker talinolol in humans

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7 January 2021

Interindividual variability in inhibition and induction of cytochrome P450 enzymes

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7 January 2021

Effect of intestinal P-glycoprotein on daily tacrolimus trough level in a living-donor small bowel recipient

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7 January 2021

HIV-1 protease inhibitors and the MDR1 multidrug transporter

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7 January 2021

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900171-0

7 January 2021

Use of area under the curve to estimate absolute bioavailability of digoxin

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900171-0

7 January 2021

Role of pharmacokinetics in the discovery and development of indinavir

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900171-0

7 January 2021

Human immunodeficiency virus protease inhibitors. From drug design to clinical studies

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7 January 2021

Evidence for intestinal secretion as an additional clearance pathway of talinolol enantiomers: concentration- and dose-dependent absorption in vitro and in vivo

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900171-0

7 January 2021

Bioavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme induction

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900171-0

7 January 2021

Transport of protein-bound hormones into tissues in vivo

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900171-0

7 January 2021

Hydrogen bonding potential as a determinant of the in vitro and in situ blood-brain barrier permeability of peptides

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900171-0

7 January 2021

Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability

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7 January 2021

Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein

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7 January 2021

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites

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7 January 2021

P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells

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7 January 2021

Restricted transport of cyclosporin A across the blood-brain barrier by a multidrug transporter, P-glycoprotein.

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7 January 2021

Transport of cyclosporin A across the brain capillary endothelial cell monolayer by P-glycoprotein

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7 January 2021

Isolation and culture of human brain microvessel endothelial cells for the study of blood-brain barrier properties in vitro.

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7 January 2021

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

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7 January 2021

Specialized localization of P-glycoprotein recognized by MRK 16 monoclonal antibody in endothelial cells of the brain and the spinal cord

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7 January 2021

Spinal cord bioavailability of methylprednisolone after intravenous and intrathecal administration: the role of P-glycoprotein

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7 January 2021

Steady-state pharmacokinetics of indinavir in cerebrospinal fluid and plasma among adults with human immunodeficiency virus type 1 infection

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7 January 2021

Effect of ketoconazole on ritonavir and saquinavir concentrations in plasma and cerebrospinal fluid from patients infected with human immunodeficiency virus.

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7 January 2021

BBB transport and P-glycoprotein functionality using MDR1A (-/-) and wild-type mice. Total brain versus microdialysis concentration profiles of rhodamine-123.

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7 January 2021

P-glycoprotein-dependent disposition kinetics of tacrolimus: studies in mdr1a knockout mice

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7 January 2021

Function of P-glycoprotein expressed in placenta and mole

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7 January 2021

Human placental transport of vinblastine, vincristine, digoxin and progesterone: contribution of P-glycoprotein.

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900171-0

7 January 2021

Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900171-0

7 January 2021

Placental P-glycoprotein deficiency enhances susceptibility to chemically induced birth defects in mice

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900171-0

7 January 2021

Extrahepatic metabolism of drugs in humans

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900171-0

7 January 2021

Distribution and induction of CYP3A1 and CYP3A2 in rat liver and extrahepatic tissues

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7 January 2021

Distribution of cytochromes P-450, cytochrome b5, and NADPH-cytochrome P-450 reductase in an entire human liver

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900171-0

7 January 2021

The immunocytochemical localisation and distribution of cytochrome P-450 in normal human hepatic and extrahepatic tissues with a monoclonal antibody to human cytochrome P-450

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900171-0

7 January 2021

Enzyme-catalyzed processes of first-pass hepatic and intestinal drug extraction

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7 January 2021

Interplay between CYP3A-mediated metabolism and polarized efflux of terfenadine and its metabolites in intestinal epithelial Caco-2 (TC7) cell monolayers

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900171-0

7 January 2021

Expression of enzymatically active CYP3A4 by Caco-2 cells grown on extracellular matrix-coated permeable supports in the presence of 1alpha,25-dihydroxyvitamin D3.

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7 January 2021

Molecular pharmacology of organic cation transporters in kidney

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7 January 2021

Kinetic analysis of hepatobiliary transport of vincristine in perfused rat liver. Possible roles of P-glycoprotein in biliary excretion of vincristine

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7 January 2021

Hepatic extraction, metabolism and biliary excretion of doxorubicin in the isolated prefused rat liver

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7 January 2021

Physiologically based pharmacokinetics of digoxin in mdr1a knockout mice.

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7 January 2021

Contribution of the murine mdr1a P-glycoprotein to hepatobiliary and intestinal elimination of cationic drugs as measured in mice with an mdr1a gene disruption.

1 reference

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7 January 2021

Hepatobiliary and intestinal clearance of amphiphilic cationic drugs in mice in which both mdr1a and mdr1b genes have been disrupted

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7 January 2021

Increased accumulation of doxorubicin and doxorubicinol in cardiac tissue of mice lacking mdr1a P-glycoprotein

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7 January 2021

Inhibition and induction of cytochrome P450 and the clinical implications

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7 January 2021

Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies

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7 January 2021

Experimental reversal of P-glycoprotein-mediated multidrug resistance by pharmacological chemosensitisers

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7 January 2021

Human P-glycoprotein exhibits reduced affinity for substrates during a catalytic transition state

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7 January 2021

The catalytic cycle of P-glycoprotein

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7 January 2021

Co-operative, competitive and non-competitive interactions between modulators of P-glycoprotein

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7 January 2021

Modulation of adriamycin accumulation and efflux by flavonoids in HCT-15 colon cells. Activation of P-glycoprotein as a putative mechanism

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900171-0

7 January 2021

Positively Cooperative Sites for Drug Transport by P‐Glycoprotein with Distinct Drug Specificities

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900171-0

7 January 2021

Competitive, non-competitive and cooperative interactions between substrates of P-glycoprotein as measured by its ATPase activity

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7 January 2021

Role of P-glycoprotein on the CNS disposition of amprenavir (141W94), an HIV protease inhibitor

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7 January 2021

Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC833

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7 January 2021

P-glycoprotein system as a determinant of drug interactions: the case of digoxin-verapamil

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7 January 2021

The influence of quinidine and other agents on digitalis glycosides

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7 January 2021

Quinidine enhances digitalis toxicity at therapeutic serum digoxin levels

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7 January 2021

Pharmacokinetics of digoxin and main metabolites/derivatives in healthy humans.

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7 January 2021

Phase I study of intravenous PSC-833 and doxorubicin: reversal of multidrug resistance

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7 January 2021

Co-administration of GF120918 significantly increases the systemic exposure to oral paclitaxel in cancer patients

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7 January 2021

Phase I study of paclitaxel in combination with a multidrug resistance modulator, PSC 833 (Valspodar), in refractory malignancies.

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7 January 2021

Phase I study of etoposide with SDZ PSC 833 as a modulator of multidrug resistance in patients with cancer

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7 January 2021

Development of multidrug-resistance convertors: sense or nonsense?

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7 January 2021

P-glycoprotein induction in rat liver epithelial cells in response to acute 3-methylcholanthrene treatment

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7 January 2021

Pregnane X receptor: molecular basis for species differences in CYP3A induction by xenobiotics

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7 January 2021

Regulation by dexamethasone of P-glycoprotein expression in cultured rat hepatocytes.

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7 January 2021

Modulation of multidrug resistance gene expression by dexamethasone in cultured hepatoma cells

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7 January 2021

Modulation of P-glycoprotein expression by cytochrome P450 3A inducers in male and female rat livers

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900171-0

7 January 2021

Chronic cyclosporine administration induces renal P-glycoprotein in rats

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900171-0

7 January 2021

Induction of P-glycoprotein mRNA transcripts by cycloheximide in animal tissues: evidence that class I Pgp is transcriptionally regulated whereas class II Pgp is post-transcriptionally regulated

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7 January 2021

St John's Wort induces intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP3A4

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7 January 2021

Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy.

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7 January 2021

Localization of the human multiple drug resistance gene, MDR1, to 7q21.1

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900171-0

7 January 2021

Assignment of the human cytochrome P-450 nifedipine oxidase gene (CYP3A4) to chromosome 7 at band q22.1 by fluorescence in situ hybridization

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900171-0

7 January 2021

The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution

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7 January 2021

SXR, a novel steroid and xenobiotic-sensing nuclear receptor

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7 January 2021

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900171-0

7 January 2021

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900171-0

7 January 2021

Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900171-0

7 January 2021

The expression of pregnane X receptor and its target gene, cytochrome P450 3A1, in perinatal mouse

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900171-0

7 January 2021

The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900171-0

7 January 2021

Induction of P-glycoprotein by rifampin increases intestinal secretion of talinolol in human beings: a new type of drug/drug interaction

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900171-0

7 January 2021

The effect of rifampin administration on the disposition of fexofenadine

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900171-0

7 January 2021

Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900171-0

7 January 2021

Characterization of the regional intestinal kinetics of drug efflux in rat and human intestine and in Caco-2 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900171-0

7 January 2021

10.1016/S0169-409X(02)00171-0

Identifiers

DOI

1 reference

11 February 2018

1 reference

11 February 2018