(Q34986247)

5 August 2017

title

The mTOR kinase inhibitors, CC214-1 and CC214-2, preferentially block the growth of EGFRvIII-activated glioblastomas (English)

1 reference

5 August 2017

25

Guido Kroemer

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Bruno Bonetti

object named as

Bruno Bonetti

18

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Timothy F. Cloughesy

29

object named as

Timothy F Cloughesy

1 reference

5 August 2017

Beatrice Gini

1

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5 August 2017

Ciro Zanca

2

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5 August 2017

Deliang Guo

3

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5 August 2017

Tomoo Matsutani

4

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5 August 2017

Kenta Masui

5

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5 August 2017

Shiro Ikegami

6

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5 August 2017

Huijun Yang

7

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5 August 2017

David Nathanson

8

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5 August 2017

Genaro R Villa

9

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5 August 2017

David Shackelford

10

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5 August 2017

Shaojun Zhu

11

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5 August 2017

Kazuhiro Tanaka

12

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5 August 2017

Ivan Babic

13

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5 August 2017

David Akhavan

14

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5 August 2017

Kelly Lin

15

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5 August 2017

Alvaro Assuncao

16

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5 August 2017

Yuchao Gu

17

1 reference

5 August 2017

Deborah S Mortensen

19

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5 August 2017

Shuichan Xu

20

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5 August 2017

Heather K Raymon

21

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5 August 2017

Webster K Cavenee

22

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5 August 2017

Frank B Furnari

23

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5 August 2017

C David James

24

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5 August 2017

James R Heath

26

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5 August 2017

Kristen Hege

27

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5 August 2017

Rajesh Chopra

28

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5 August 2017

Paul S Mischel

30

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5 August 2017

language of work or name

English

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publication date

12 September 2013

1 reference

5 August 2017

published in

Clinical Cancer Research

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5 August 2017

volume

19

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5 August 2017

issue

20

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5 August 2017

page(s)

5722-5732

1 reference

Use of core modification in the discovery of CC214-2, an orally available, selective inhibitor of mTOR kinase

5 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815450

A unifying model for mTORC1-mediated regulation of mRNA translation.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815450

mTOR inhibitors synergize on regression, reversal of gene expression, and autophagy in hepatocellular carcinoma.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815450

Deconvoluting the context-dependent role for autophagy in cancer

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815450

mTOR signaling in growth control and disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815450

Oncogenic EGFR signaling activates an mTORC2-NF-κB pathway that promotes chemotherapy resistance

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815450

An LXR agonist promotes glioblastoma cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent pathway

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815450

Discovery and SAR exploration of a novel series of imidazo[4,5-b]pyrazin-2-ones as potent and selective mTOR kinase inhibitors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815450

Transcriptional control of cellular metabolism by mTOR signaling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815450

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815450

Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815450

Akt and autophagy cooperate to promote survival of drug-resistant glioma

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815450

mTOR regulation of autophagy

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815450

Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815450

Modular nucleic acid assembled p/MHC microarrays for multiplexed sorting of antigen-specific T cells.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815450

An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815450

Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815450

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815450

Bimodal viral vectors and in vivo imaging reveal the fate of human neural stem cells in experimental glioma model

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815450

Novel autoantigens recognized by CSF IgG from Hashimoto's encephalitis revealed by a proteomic approach.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815450

Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815450

Malignant astrocytic glioma: genetics, biology, and paths to treatment

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815450

DNA-encoded antibody libraries: a unified platform for multiplexed cell sorting and detection of genes and proteins

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815450

Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815450

Identification of molecular characteristics correlated with glioblastoma sensitivity to EGFR kinase inhibition through use of an intracranial xenograft test panel

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815450

Phase II trial of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: a North Central Cancer Treatment Group Study

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815450

10.1158/1078-0432.CCR-13-0527

26 October 2018

Identifiers

DOI

1 reference

5 August 2017

1 reference

5 August 2017

1 reference