(Q34987493)

5 August 2017

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title

Structural biology of the C1 complex of complement unveils the mechanisms of its activation and proteolytic activity (English)

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5 August 2017

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Gérard J Arlaud

1

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5 August 2017

Christine Gaboriaud

2

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5 August 2017

Nicole M Thielens

3

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5 August 2017

Monika Budayova-Spano

4

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5 August 2017

Véronique Rossi

5

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5 August 2017

Juan Carlos Fontecilla-Camps

6

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5 August 2017

language of work or name

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1 November 2002

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5 August 2017

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5 August 2017

39

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5 August 2017

383-394

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5 August 2017

7-8

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Cl̄r and Cl̄s subcomponents of human complement: Two serine proteinases lacking the ‘histidine-loop’ disulphide bridge

5 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Human complement serine proteases C1r and C1s and their proenzymes

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Molecular characterization of the catalytic domains of human complement serine protease C1r

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

A functional model of the human C1 complex

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Identification of erythro-beta-hydroxyasparagine in the EGF-like domain of human C1r.

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Complete amino acid sequence of the A chain of human complement-classical-pathway enzyme C1r

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Structural biology of C1: dissection of a complex molecular machinery

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Solution structure of a pair of complement modules by nuclear magnetic resonance

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Solution structure of the epidermal growth factor (EGF)-like module of human complement protease C1r, an atypical member of the EGF family

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Cloning and characterization of CRF, a novel C1q-related factor, expressed in areas of the brain involved in motor function

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Insight into Schmid metaphyseal chondrodysplasia from the crystal structure of the collagen X NC1 domain trimer

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Complement components C1r/C1s, bone morphogenic protein 1 and Xenopus laevis developmentally regulated protein UVS.2 share common repeats

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

The CUB domain. A widespread module in developmentally regulated proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Structure and distribution of modules in extracellular proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Neutron scattering studies of the isolated C1r2C1s2 subunit of first component of human complement in solution

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

The crystal structure of the zymogen catalytic domain of complement protease C1r reveals that a disruptive mechanical stress is required to trigger activation of the C1 complex

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Monomeric structures of the zymogen and active catalytic domain of complement protease c1r: further insights into the c1 activation mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Calcium-sensitive thermal transitions and domain structure of human complement subcomponent C1r.

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Amino-terminal calcium-binding domain of human complement C1.hivin.s mediates the interaction of C1.hivin.r with C1q

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Epidermal growth factor-like modules

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

1 reference

7 January 2021

Functional effects of domain deletions in a multidomain serine protease, C1r.

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

The complement system in xenotransplantation

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Solution structure of a pair of calcium-binding epidermal growth factor-like domains: implications for the Marfan syndrome and other genetic disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

The instructive role of innate immunity in the acquired immune response

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Complement and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Evolutionary conserved rigid module-domain interactions can be detected at the sequence level: the examples of complement and blood coagulation proteases

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Crystal structure of the catalytic domain of human complement c1s: a serine protease with a handle

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Chemical synthesis and characterization of the epidermal growth factor-like module of human complement protease C1r

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Phylogenetic perspectives in innate immunity

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Chemical characterization and location of ionic interactions involved in the assembly of the C1 complex of human complement

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Structure of tumour necrosis factor

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Cloning and sequencing of full-length cDNA encoding the precursor of human complement component C1r

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

The role of the individual domains in the structure and function of the catalytic region of a modular serine protease, C1r.

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

C1q: structure, function, and receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Complement facilitates early prion pathogenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Isolation and functional characterization of the proenzyme form of the catalytic domains of human C1r.

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Structure and assembly of the catalytic region of human complement protease C1r: a three-dimensional model based on chemical cross-linking and homology modeling.

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Assembly and enzymatic properties of the catalytic domain of human complement protease C1r.

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Subunit interactions in the first component of complement, C1

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Nucleotide sequence of the cDNA coding for human complement C1r

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Recombinant human complement subcomponent C1s lacking beta-hydroxyasparagine, sialic acid, and one of its two carbohydrate chains still reassembles with C1q and C1r to form a functional C1 complex

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Temporary depletion of complement component C3 or genetic deficiency of C1q significantly delays onset of scrapie.

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

The co-crystal structure of unliganded bovine alpha-thrombin and prethrombin-2: movement of the Tyr-Pro-Pro-Trp segment and active site residues upon ligand binding

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Calorimetric investigation of the domain structure of human complement Cl-s: reversible unfolding of the short consensus repeat units

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Neutron scattering studies of subcomponent C1q of first component C1 of human complement and its association with subunit C1r2C1s2 within C1

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Evolutionary divergence of substrate specificity within the chymotrypsin-like serine protease fold

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Analysis of the N-linked oligosaccharides of human C1s using electrospray ionisation mass spectrometry

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Conformation and restricted segmental flexibility of C1, the first component of human complement

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

The structure of a Ca(2+)-binding epidermal growth factor-like domain: its role in protein-protein interactions

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Proteins involved in the activation and control of the two pathways of human complement

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Subunit composition and structure of subcomponent C1q of the first component of human complement

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Complement system proteins which interact with C3b or C4b A superfamily of structurally related proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Complement activation by beta-amyloid in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Crystal structure of acidic seminal fluid protein (aSFP) at 1.9 Å resolution: a bovine polypeptide of the spermadhesin family

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

The crystal structures of two spermadhesins reveal the CUB domain fold

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Structure of the catalytic region of human complement protease C1s: study by chemical cross-linking and three-dimensional homology modeling

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Baculovirus-mediated expression of truncated modular fragments from the catalytic region of human complement serine protease C1s. Evidence for the involvement of both complement control protein modules in the recognition of the C4 protein substrate

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Semi-flexible joint in the C1q subunit of the first component of human complement

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

A molecular mechanism for the activation of the first component of complement by immune complexes.

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Activation of the first component of complement

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Measurement of the association constants of the complexes formed between intact C1q or pepsin-treated C1q stalks and the unactivated or activated C1r2C1s2 tetramers

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Beta-sheet secondary structure of the trimeric globular domain of C1q of complement and collagen types VIII and X by Fourier-transform infrared spectroscopy and averaged structure predictions

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Ultrastructure of the first component of human complement: electron microscopy of the crosslinked complex

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

The relative orientation of Gla and EGF domains in coagulation factor X is altered by Ca2+ binding to the first EGF domain. A combined NMR-small angle X-ray scattering study

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Beta-amyloid fibrils activate the C1 complex of complement under physiological conditions: evidence for a binding site for A beta on the C1q globular regions

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Chemical and functional characterization of a fragment of C1-s containing the epidermal growth factor homology region

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Activation of human complement serine-proteinase C1r is down-regulated by a Ca(2+)-dependent intramolecular control that is released in the C1 complex through a signal transmitted by C1q.

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

The N-terminal CUB-epidermal growth factor module pair of human complement protease C1r binds Ca2+ with high affinity and mediates Ca2+-dependent interaction with C1s.

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Expression and characterization of a 159 amino acid, N-terminal fragment of human complement component C1s.

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Assembly of subcomponents C1r and C1s of first component of complement: electron microscopic and ultracentrifugal studies

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

The 2.4 Å resolution crystal structure of boar seminal plasma PSP-I/PSP-II: a zona pellucida-binding glycoprotein heterodimer of the spermadhesin family built by a CUB domain architecture

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Domain structure and associated functions of subcomponents C1r and C1s of the first component of human complement

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

Functional model of subcomponent C1 of human complement

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

NMR studies of a viral protein that mimics the regulators of complement activation

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900143-8

7 January 2021

10.1016/S0161-5890(02)00143-8

Identifiers

DOI

1 reference

5 August 2017

1 reference