(Q34990599)

5 August 2017

1 reference

title

Do oxidatively modified proteins cause ALS? (English)

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amyotrophic lateral sclerosis

5 August 2017

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inferred from title

author name string

Joan Selverstone Valentine

series ordinal

1

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5 August 2017

1 November 2002

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Free Radical Biology and Medicine

5 August 2017

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5 August 2017

33

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5 August 2017

10

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5 August 2017

1314-1320

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Amyotrophic lateral sclerosis

5 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

Homozygosity for Asn86Ser mutation in the CuZn-superoxide dismutase gene produces a severe clinical phenotype in a juvenile onset case of familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

Amyotrophic lateral sclerosis associated with homozygosity for an Asp90Ala mutation in CuZn-superoxide dismutase

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

A low expressor line of transgenic mice carrying a mutant human Cu,Zn superoxide dismutase (SOD1) gene develops pathological changes that most closely resemble those in human amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

Neuropathological changes in two lines of mice carrying a transgene for mutant human Cu,Zn SOD, and in mice overexpressing wild type human SOD: a model of familial amyotrophic lateral sclerosis (FALS).

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

Transgenic animal models of familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

Loss of in vitro metal ion binding specificity in mutant copper-zinc superoxide dismutases associated with familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

Subunit asymmetry in the three-dimensional structure of a human CuZnSOD mutant found in familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

Reactions of hydrogen peroxide with familial amyotrophic lateral sclerosis mutant human copper-zinc superoxide dismutases studied by pulse radiolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

Decreased metallation and activity in subsets of mutant superoxide dismutases associated with familial amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

Familial amyotrophic lateral sclerosis-associated mutations decrease the thermal stability of distinctly metallated species of human copper/zinc superoxide dismutase

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

Copper(2+) binding to the surface residue cysteine 111 of His46Arg human copper-zinc superoxide dismutase, a familial amyotrophic lateral sclerosis mutant

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

Aberrant protein deposition and neurological disease

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

Amyotrophic lateral sclerosis. unfolding the toxicity of the misfolded

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

Histological evidence of protein aggregation in mutant SOD1 transgenic mice and in amyotrophic lateral sclerosis neural tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

Formation of granular cytoplasmic aggregates in COS7 cells expressing mutant Cu/Zn superoxide dismutase associated with familial amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

Aggregation of mutant Cu/Zn superoxide dismutase proteins in a culture model of ALS

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

Immunohistochemical study on superoxide dismutases in spinal cords from autopsied patients with amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

Cu/Zn superoxide dismutase-like immunoreactivity in Lewy body-like inclusions of sporadic amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

Formation of high molecular weight complexes of mutant Cu, Zn-superoxide dismutase in a mouse model for familial amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

Aggregation of ubiquitin and a mutant ALS-linked SOD1 protein correlate with disease progression and fragmentation of the Golgi apparatus

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

The neuronal Golgi apparatus is fragmented in transgenic mice expressing a mutant human SOD1, but not in mice expressing the human NF-H gene

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

Aggregates of mutant protein appear progressively in dendrites, in periaxonal processes of oligodendrocytes, and in neuronal and astrocytic perikarya of mice expressing the SOD1(G93A) mutation of familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

The Golgi apparatus of spinal cord motor neurons in transgenic mice expressing mutant Cu,Zn superoxide dismutase becomes fragmented in early, preclinical stages of the disease

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

New consensus research on neuropathological aspects of familial amyotrophic lateral sclerosis with superoxide dismutase 1 (SOD1) gene mutations: inclusions containing SOD1 in neurons and astrocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

Advanced glycation endproduct-modified superoxide dismutase-1 (SOD1)-positive inclusions are common to familial amyotrophic lateral sclerosis patients with SOD1 gene mutations and transgenic mice expressing human SOD1 with a G85R mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

Morphological evidence for lipid peroxidation and protein glycoxidation in spinal cords from sporadic amyotrophic lateral sclerosis patients

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

Nonoxidative protein glycation is implicated in familial amyotrophic lateral sclerosis with superoxide dismutase-1 mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

Enhanced oxygen radical production in a transgenic mouse model of familial amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

Elevated "hydroxyl radical" generation in vivo in an animal model of amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

Mutations in copper-zinc superoxide dismutase that cause amyotrophic lateral sclerosis alter the zinc binding site and the redox behavior of the protein

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

Characterization of wild-type and amyotrophic lateral sclerosis-related mutant Cu,Zn-superoxide dismutases overproduced in baculovirus-infected insect cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

A gain-of-function of an amyotrophic lateral sclerosis-associated Cu,Zn-superoxide dismutase mutant: An enhancement of free radical formation due to a decrease in Km for hydrogen peroxide

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

Gain in functions of mutant Cu,Zn-superoxide dismutases as a causative factor in familial amyotrophic lateral sclerosis: less reactive oxidant formation but high spontaneous aggregation and precipitation

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

Decreased zinc affinity of amyotrophic lateral sclerosis-associated superoxide dismutase mutants leads to enhanced catalysis of tyrosine nitration by peroxynitrite

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

Induction of nitric oxide-dependent apoptosis in motor neurons by zinc-deficient superoxide dismutase

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

Protein oxidative damage in a transgenic mouse model of familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

ALS, SOD and peroxynitrite

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

In vivo peroxidative activity of FALS-mutant human CuZnSODs expressed in yeast

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

A familial amyotrophic lateral sclerosis-associated A4V Cu, Zn-superoxide dismutase mutant has a lower Km for hydrogen peroxide. Correlation between clinical severity and the Km value.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

Bicarbonate enhances the hydroxylation, nitration, and peroxidation reactions catalyzed by copper, zinc superoxide dismutase. Intermediacy of carbonate anion radical

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

Bicarbonate is required for the peroxidase function of Cu, Zn-superoxide dismutase at physiological pH

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

Reexamination of the mechanism of hydroxyl radical adducts formed from the reaction between familial amyotrophic lateral sclerosis-associated Cu,Zn superoxide dismutase mutants and H2O2.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

Oxidation versus aggregation - how do SOD1 mutants cause ALS?

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

SOD1 aggregates in ALS: cause, correlate or consequence?

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

Mutant SOD1 causes motor neuron disease independent of copper chaperone-mediated copper loading

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

Copper chaperone for superoxide dismutase is essential to activate mammalian Cu/Zn superoxide dismutase

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

A proposed mechanism of ALS fails the test in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

Do posttranslational modifications of CuZnSOD lead to sporadic amyotrophic lateral sclerosis?

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

Toxic proteins in neurodegenerative disease

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2901080-8

7 January 2021

10.1016/S0891-5849(02)01080-8

Identifiers

DOI

1 reference

5 August 2017

1 reference

PubMed ID

12419463