(Q34991808)

5 August 2017

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title

The role of soluble receptors in cytokine biology: the agonistic properties of the sIL-6R/IL-6 complex (English)

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5 August 2017

Simon A Jones

1

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Stefan Rose-John

object named as

Stefan Rose-John

series ordinal

2

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language of work or name

English

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publication date

1 November 2002

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Biochimica et Biophysica Acta

5 August 2017

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5 August 2017

1592

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5 August 2017

251-263

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5 August 2017

3

1 reference

Soluble receptors for cytokines and growth factors: generation and biological function

5 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Membrane protein secretases

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Metalloprotease-disintegrins: links to cell adhesion and cleavage of TNF alpha and Notch

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Soluble cytokine receptors are present in normal human urine

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

The soluble interleukin 6 receptor: mechanisms of production and implications in disease

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Role of Metalloproteases in the Release of the IL-1 type II Decoy Receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Soluble type II interleukin 1 (IL-1) receptor binds and blocks processing of IL-1 beta precursor and loses affinity for IL-1 receptor antagonist

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

The tumor necrosis factor ligand and receptor families.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Induction of cell death by tumour necrosis factor (TNF) receptor 2, CD40 and CD30: a role for TNF-R1 activation by endogenous membrane-anchored TNF.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned?

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

1 reference

7 January 2021

Gp130 and the interleukin-6 family of cytokines

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complex

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Signaling mechanisms through cytokine receptors that share signal transducing receptor components

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

The soluble interleukin-6 receptor is generated by shedding

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

The function of the soluble interleukin 6 (IL-6) receptor in vivo: sensitization of human soluble IL-6 receptor transgenic mice towards IL-6 and prolongation of the plasma half-life of IL-6.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

gp130 and c-Kit signalings synergize for ex vivo expansion of human primitive hemopoietic progenitor cells

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Neural activities of IL-6-type cytokines often depend on soluble cytokine receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Soluble interleukin-6 receptors released from T cell or granulocyte/macrophage cell lines and human peripheral blood mononuclear cells are generated through an alternative splicing mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Isolation of an mRNA encoding a soluble form of the human interleukin-6 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Protein kinase C activity is rate limiting for shedding of the interleukin-6 receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

High-level production of alternatively spliced soluble interleukin-6 receptor in serum of patients with adult T-cell leukaemia/HTLV-I-associated myelopathy

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Purification and characterization of the soluble interleukin-6 receptor from human plasma and identification of an isoform generated through alternative splicing

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

IL-6 and Its Soluble Receptor Orchestrate a Temporal Switch in the Pattern of Leukocyte Recruitment Seen during Acute Inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

C-reactive protein: a physiological activator of interleukin 6 receptor shedding.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Retrograde inflammatory signaling from neutrophils to endothelial cells by soluble interleukin-6 receptor alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

The IL-6-soluble IL-6Ralpha autocrine loop of endothelial activation as an intermediate between acute and chronic inflammation: an experimental model involving thrombin

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Blockade of interleukin 6 trans signaling suppresses T-cell resistanceagainst apoptosis in chronic intestinal inflammation: Evidence in Crohn diseaseand experimental colitis in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Released form of CNTF receptor alpha component as a soluble mediator of CNTF responses

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Cardiotrophin-1, a cytokine present in embryonic muscle, supports long-term survival of spinal motoneurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional responses to cardiotrophin-like cytokine

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Extramedullary expansion of hematopoietic progenitor cells in interleukin (IL)-6-sIL-6R double transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Analysis of interleukin 6 receptor and gp130 expressions and proliferative capability of human CD34+ cells

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Distinct role of gp130 activation in promoting self-renewal divisions by mitogenically stimulated murine hematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

gp130-stimulating designer cytokine Hyper-interleukin-6 synergizes with murine stroma for long-term survival of primitive human hematopoietic progenitor cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Optimization of retroviral-mediated gene transfer to human NOD/SCID mouse repopulating cord blood cells through a systematic analysis of protocol variables.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Interleukin-6 and the soluble interleukin-6 receptor induce stem cell factor and Flt-3L expression in vivo and in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

The gp130-stimulating designer cytokine hyper-IL-6 promotes the expansion of human hematopoietic progenitor cells capable to differentiate into functional dendritic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Induction of strong hepatitis B virus (HBV) specific T helper cell and cytotoxic T lymphocyte responses by therapeutic vaccination in the trimera mouse model of chronic HBV infection.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Generation of tumor-reactive CTL against the tumor-associated antigen HER2 using retrovirally transduced dendritic cells derived from CD34+ hemopoietic progenitor cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Coexpression of IL-6 and soluble IL-6R causes nodular regenerative hyperplasia and adenomas of the liver.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Hepatocellular hyperplasia, plasmacytoma formation, and extramedullary hematopoiesis in interleukin (IL)-6/soluble IL-6 receptor double-transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Combined interleukin 6 and soluble interleukin 6 receptor accelerates murine liver regeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Liver regeneration induced by a designer human IL-6/sIL-6R fusion protein reverses severe hepatocellular injury.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Hyper-IL-6 gene therapy reverses fulminant hepatic failure.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

A possible role for soluble IL-6 receptor in the pathogenesis of systemic onset juvenile chronic arthritis

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Serum levels of interleukin-6 type cytokines and soluble interleukin-6 receptor in patients with rheumatoid arthritis

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Interleukin-6 and its soluble receptor cause a marked induction of collagenase 3 expression in rat osteoblast cultures

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Effects of IL-6 and its soluble receptor on proteoglycan synthesis and NO release by human articular chondrocytes: comparison with IL-1. Modulation by dexamethasone

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

IL-6 and its soluble receptor augment aggrecanase-mediated proteoglycan catabolism in articular cartilage

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Interleukin (IL)-6 and its soluble receptor induce TIMP-1 expression in synoviocytes and chondrocytes, and block IL-1-induced collagenolytic activity

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Immunoadhesins of interleukin-6 and the IL-6/soluble IL-6R fusion protein hyper-IL-6

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Enzymatically Degraded, Nonoxidized LDL Induces Human Vascular Smooth Muscle Cell Activation, Foam Cell Transformation, and Proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Interleukin 6 is required for the development of collagen-induced arthritis

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Interleukin 6 knock-out mice are resistant to antigen-induced experimental arthritis

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Interleukin 6 plays a key role in the development of antigen-induced arthritis

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Blockage of interleukin-6 receptor ameliorates joint disease in murine collagen-induced arthritis

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Sympathetic neurons can produce and respond to interleukin 6

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Interleukin-6 (IL-6) and its soluble receptor support survival of sensory neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Role of interleukin-6 and soluble IL-6 receptor in region-specific induction of astrocytic differentiation and neurotrophin expression.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Activation of gp 130 by IL-6/soluble IL-6 receptor induces neuronal differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Studies on the structure and regulation of the human hepatic interleukin-6 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Binding in the growth hormone receptor complex

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Engineering human interleukin-6 to obtain variants with strongly enhanced bioactivity.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

The family of the IL-6-type cytokines: specificity and promiscuity of the receptor complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

IL-6 type cytokine receptor complexes: hexamer, tetramer or both?

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

A bioactive designer cytokine for human hematopoietic progenitor cell expansion

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Cellular tropism and viral interleukin-6 expression distinguish human herpesvirus 8 involvement in Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Human herpesvirus 8 encodes a homolog of interleukin-6.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Human herpes virus 8 interleukin-6 homologue triggers gp130 on neuronal and hematopoietic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

IL-6 Receptor Independent Stimulation of Human gp130 by Viral IL-6

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Structure of an extracellular gp130 cytokine receptor signaling complex

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Association of recombinant soluble IL-6-signal transducer, gp130, with a complex of IL 6 and soluble IL-6 receptor, and establishment of an ELISA for soluble gp130

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

The soluble form of the IL-6 receptor (sIL-6R alpha) is a potent growth factor for AIDS-associated Kaposi's sarcoma (KS) cells; the soluble form of gp130 is antagonistic for sIL-6R alpha-induced AIDS-KS cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Cloning and expression of an alternatively spliced mRNA encoding a soluble form of the human interleukin-6 signal transducer gp130

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Differential shedding of the two subunits of the interleukin-6 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Cloning of novel soluble gp130 and detection of its neutralizing autoantibodies in rheumatoid arthritis

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Identification and Characterization of Two Distinct Truncated Forms of gp130 and a Soluble Form of Leukemia Inhibitory Factor Receptor α-Chain in Normal Human Urine and Plasma

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Stage-specific expression of cytokine and receptor messenger ribonucleic acids in human preimplantation embryos

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Maintenance of the pluripotential phenotype of embryonic stem cells through direct activation of gp130 signalling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Interleukin-1, interleukin-1 receptors and interleukin-1 receptor antagonist.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Biology of the interleukin-2 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Biologic functions and signaling of the interleukin-4 receptor complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

IL-5: biology and potential therapeutic applications

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Interleukin-7: physiological roles and mechanisms of action

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Interleukin 9 and its receptor: an overview of structure and function

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Interleukin-10 and the interleukin-10 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Interleukin-12, a key cytokine in Th1-mediated autoimmune diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Cloning and characterization of IL-22 binding protein, a natural antagonist of IL-10-related T cell-derived inducible factor/IL-22

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Identification, cloning, and characterization of a novel soluble receptor that binds IL-22 and neutralizes its activity

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

Oncostatin M: signal transduction and biological activity

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900319-1

7 January 2021

10.1016/S0167-4889(02)00319-1

Identifiers

DOI

1 reference

5 August 2017

1 reference

PubMed ID

12421670