(Q34992549)

5 August 2017

title

Insight into the mechanism of inhibition of adeno-associated virus by the Mre11/Rad50/Nbs1 complex (English)

1 reference

5 August 2017

Thomas B Lentz

1

1 reference

5 August 2017

R Jude Samulski

series ordinal

2

1 reference

5 August 2017

language of work or name

English

0 references

publication date

15 October 2014

1 reference

5 August 2017

1 reference

5 August 2017

volume

89

1 reference

5 August 2017

issue

1

1 reference

5 August 2017

page(s)

181-194

1 reference

describes a project that uses

5 August 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4301101/fullTextXML

inferred from PubMed Central ID database lookup

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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The Mre11/Rad50/Nbs1 complex limits adeno-associated virus transduction and replication

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301101

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8 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301101

The Mre11-Rad50-Nbs1 complex acts both upstream and downstream of ataxia telangiectasia mutated and Rad3-related protein (ATR) to regulate the S-phase checkpoint following UV treatment.

8 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301101

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8 July 2018

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8 July 2018

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Adenovirus ubiquitin-protein ligase stimulates viral late mRNA nuclear export

8 July 2018

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8 July 2018

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Helper functions required for wild type and recombinant adeno-associated virus growth.

8 July 2018

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8 July 2018

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Serotype-specific reorganization of the Mre11 complex by adenoviral E4orf3 proteins

8 July 2018

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Relocalization of the Mre11-Rad50-Nbs1 complex by the adenovirus E4 ORF3 protein is required for viral replication

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301101

DNA repair proteins affect the lifecycle of herpes simplex virus 1.

8 July 2018

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Integration of adeno-associated virus (AAV) and recombinant AAV vectors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301101

MRE11/RAD50/NBS1: complex activities

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301101

Recruitment of cellular recombination and repair proteins to sites of herpes simplex virus type 1 DNA replication is dependent on the composition of viral proteins within prereplicative sites and correlates with the induction of the DNA damage respo

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301101

A parvovirus isolated from royal python (Python regius) is a member of the genus Dependovirus.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301101

Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301101

The Mre11 complex is required for ATM activation and the G2/M checkpoint

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301101

Requirement of the MRN complex for ATM activation by DNA damage

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301101

Primary fibroblasts of Cockayne syndrome patients are defective in cellular repair of 8-hydroxyguanine and 8-hydroxyadenine resulting from oxidative stress

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301101

Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301101

An ATR- and Chk1-dependent S checkpoint inhibits replicon initiation following UVC-induced DNA damage

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301101

Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301101

The Mre11 complex: at the crossroads of dna repair and checkpoint signalling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301101

A murine model of Nijmegen breakage syndrome

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301101

Cross-packaging of a single adeno-associated virus (AAV) type 2 vector genome into multiple AAV serotypes enables transduction with broad specificity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301101

Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301101

Self-complementary recombinant adeno-associated virus (scAAV) vectors promote efficient transduction independently of DNA synthesis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301101

DNA structure-specific nuclease activities in the Saccharomyces cerevisiae Rad50*Mre11 complex

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301101

DNA-binding and strand-annealing activities of human Mre11: implications for its roles in DNA double-strand break repair pathways

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301101

Adeno-associated virus type 2 Rep78 induces apoptosis through caspase activation independently of p53.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301101

Loss of ATM function enhances recombinant adeno-associated virus transduction and integration through pathways similar to UV irradiation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301101

The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301101

Inducible long-term gene expression in brain with adeno-associated virus gene transfer

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301101

The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301101

In situ visualization of DNA double-strand break repair in human fibroblasts

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301101

Production of high-titer recombinant adeno-associated virus vectors in the absence of helper adenovirus

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301101

Gene transfer by adeno-associated virus vectors into the central nervous system

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301101

Structural analysis of the adenovirus type 5 E1B 55-kilodalton-E4orf6 protein complex

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301101

A "humanized" green fluorescent protein cDNA adapted for high-level expression in mammalian cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301101

Second-strand synthesis is a rate-limiting step for efficient transduction by recombinant adeno-associated virus vectors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301101

Transduction with recombinant adeno-associated virus for gene therapy is limited by leading-strand synthesis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301101

Isolation of two cell lines from a human malignant glioma specimen differing in sensitivity to radiation and chemotherapeutic drugs

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301101

The Bloom's syndrome gene product is homologous to RecQ helicases

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301101

Nucleotide sequence and organization of the adeno-associated virus 2 genome

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301101

Nucleotide sequence of the inverted terminal repetition in adeno-associated virus DNA

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301101

Adenovirus early region 4 encodes functions required for efficient DNA replication, late gene expression, and host cell shutoff

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301101

Adenovirus E1B proteins are required for accumulation of late viral mRNA and for effects on cellular mRNA translation and transport

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301101

Adenovirus E1B 55-Mr polypeptide facilitates timely cytoplasmic accumulation of adeno-associated virus mRNAs.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301101

Helper-free stocks of recombinant adeno-associated viruses: normal integration does not require viral gene expression

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301101

The adenovirus E1B 55 kd protein influences mRNA transport via an intranuclear effect on RNA metabolism

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301101

Rolling hairpin model for replication of parvovirus and linear chromosomal DNA

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301101

Adeno-associated virus replication induces a DNA damage response coordinated by DNA-dependent protein kinase

8 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1128%2FJVI.01990-14

Structural analysis of adeno-associated virus transduction circular intermediates.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1128%2FJVI.01990-14

Virus-mediated killing of cells that lack p53 activity

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1128%2FJVI.01990-14

ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25320294

12 December 2020

inferred from PubMed ID database lookup

Homozygous and compound heterozygous mutations at the Werner syndrome locus

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25320294

12 December 2020

inferred from PubMed ID database lookup

The cellular Mre11 protein interferes with adenovirus E4 mutant DNA replication

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25320294

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1128/JVI.01990-14

1 reference

5 August 2017

1 reference

5 August 2017

1 reference