(Q34993154)

5 August 2017

Medicinal chemistry approaches for the treatment and prevention of Alzheimer's disease (English)

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5 August 2017

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Bachurin SO

1

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PubMed ID

12424753

5 August 2017

language of work or name

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1 January 2003

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Medicinal Research Reviews

5 August 2017

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5 August 2017

23

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5 August 2017

48-88

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5 August 2017

1

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Prevalence and types of dementia in the very old: results from the Canadian Study of Health and Aging.

5 August 2017

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Alzheimer disease and associated disorders: project funding opportunities within the European community

21 January 2018

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Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset.

21 January 2018

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The molecular pathology of Alzheimer's disease

21 January 2018

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Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans.

21 January 2018

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Alzheimer's disease: more than a 'cholinergic disorder' - evidence that cholinergic-monoaminergic interactions contribute to EEG slowing and dementia

21 January 2018

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Selective loss of central cholinergic neurons in Alzheimer's disease

21 January 2018

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The cholinergic hypothesis of geriatric memory dysfunction

21 January 2018

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Protease inhibitors and indolamines selectively inhibit cholinesterases in the histopathologic structures of Alzheimer's disease

21 January 2018

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A comparative study in rats of the in vitro and in vivo pharmacology of the acetylcholinesterase inhibitors tacrine, donepezil and NXX-066.

21 January 2018

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21 January 2018

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Galantamine: a review of its use in Alzheimer's disease

21 January 2018

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Efficacy and safety of eptastigmine for the treatment of patients with Alzheimer's disease.

21 January 2018

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The pharmacological basis for metrifonate's favourable tolerability in the treatment of Alzheimer's disease.

21 January 2018

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Huperzine A, a potential therapeutic agent for treatment of Alzheimer's disease

21 January 2018

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Pharmacodynamic-tolerability relationships of cholinesterase inhibitors for Alzheimer's disease.

21 January 2018

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Amyloid precursor protein in platelets of patients with Alzheimer disease: effect of acetylcholinesterase inhibitor treatment

21 January 2018

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Acetylcholinesterase accelerates assembly of amyloid-beta-peptides into Alzheimer's fibrils: possible role of the peripheral site of the enzyme.

21 January 2018

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Butyrylcholinesterase in the life cycle of amyloid plaques.

21 January 2018

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Do cholinesterase inhibitors have disease-modifying effects in Alzheimer's disease?

21 January 2018

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Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors

21 January 2018

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Muscarinic agonists in Alzheimer's disease.

21 January 2018

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Muscarinic acetylcholine receptors activate expression of the EGR gene family of transcription factors

21 January 2018

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The profile of sabcomeline (SB-202026), a functionally selective M1 receptor partial agonist, in the marmoset

21 January 2018

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Neuronal nicotinic receptor subtypes

21 January 2018

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Nicotinic antagonist administration into the ventral hippocampus and spatial working memory in rats.

21 January 2018

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Expression of nicotinic acetylcholine receptor subunits in the cerebral cortex in Alzheimer's disease: histotopographical correlation with amyloid plaques and hyperphosphorylated-tau protein.

21 January 2018

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Nicotinic receptor abnormalities of Alzheimer's disease: therapeutic implications.

21 January 2018

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Acute effects of the selective cholinergic channel activator (nicotinic agonist) ABT-418 in Alzheimer's disease

21 January 2018

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4-[[2-(1-Methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride (SIB-1553A): a novel cognitive enhancer with selectivity for neuronal nicotinic acetylcholine receptors

21 January 2018

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Some blood biochemistry parameters during the cholinergic treatment of Alzheimer's disease.

21 January 2018

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A 1-year controlled trial of acetyl-l-carnitine in early-onset AD.

21 January 2018

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Novel carbamates as potent histamine H3 receptor antagonists with high in vitro and oral in vivo activity

21 January 2018

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Effects of clobenpropit (VUF-9153), a histamine H3-receptor antagonist, on learning and memory, and on cholinergic and monoaminergic systems in mice.

21 January 2018

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A novel series of (phenoxyalkyl)imidazoles as potent H3-receptor histamine antagonists.

21 January 2018

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Protective effect of MKC-231, a novel high affinity choline uptake enhancer, on glutamate cytotoxicity in cultured cortical neurons.

21 January 2018

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Alzheimer's disease: the amyloid cascade hypothesis

21 January 2018

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Prospects for pharmacological intervention in Alzheimer disease

21 January 2018

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Alzheimer's disease and the amyloid beta protein: What is the role of amyloid?

21 January 2018

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

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In search of gamma-secretase: presenilin at the cutting edge

21 January 2018

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Gamma-secretase: never more enigmatic

21 January 2018

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Inhibitors of V-type ATPases, bafilomycin A1 and concanamycin A, protect against beta-amyloid-mediated effects on 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction.

21 January 2018

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Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

21 January 2018

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Statins and the risk of dementia

21 January 2018

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Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model

21 January 2018

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Link between heart disease, cholesterol, and Alzheimer's disease: a review

21 January 2018

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Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo

21 January 2018

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Mechanisms of neuronal degeneration in Alzheimer's disease

21 January 2018

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Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer's therapy.

21 January 2018

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Controlling polymerization of beta-amyloid and prion-derived peptides with synthetic small molecule ligands.

21 January 2018

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Laminin 1 attenuates beta-amyloid peptide Abeta(1-40) neurotoxicity of cultured fetal rat cortical neurons.

21 January 2018

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Neurotoxicity of acetylcholinesterase amyloid beta-peptide aggregates is dependent on the type of Abeta peptide and the AChE concentration present in the complexes.

21 January 2018

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Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

21 January 2018

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Modulation of Alzheimer's beta-amyloid neurotoxicity by site-directed single-chain antibody.

21 January 2018

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A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

21 January 2018

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A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease.

21 January 2018

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The role of excitotoxicity in neurodegenerative disease: implications for therapy

21 January 2018

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Dementia of the Alzheimer's type: changes in hippocampal L-[3H]glutamate binding.

21 January 2018

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Adverse psychological impact, glutamatergic dysfunction, and risk factors for Alzheimer's disease.

21 January 2018

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Memantine in severe dementia: results of the 9M-Best Study (Benefit and efficacy in severely demented patients during treatment with memantine).

21 January 2018

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AMPA receptors: potential implications in development and disease

21 January 2018

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Memory and the brain: unexpected chemistries and a new pharmacology

21 January 2018

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Evidence that a positive modulator of AMPA-type glutamate receptors improves delayed recall in aged humans.

21 January 2018

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d-Cycloserine: effects on long-term retention of a conditioned response and on memory for contextual attributes.

21 January 2018

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Priming of cultured neurons with sabeluzole results in long-lasting inhibition of neurotoxin-induced tau expression and cell death

21 January 2018

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Effects of Gastrodia elata and its active constituents on scopolamine-induced amnesia in rats

21 January 2018

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Metabotropic glutamate receptor activation and blockade: their role in long-term potentiation, learning and neurotoxicity.

21 January 2018

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Excitotoxic neurodegeneration in Alzheimer disease. New hypothesis and new therapeutic strategies

21 January 2018

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Presenilin-1 mutations in Alzheimer's disease.

21 January 2018

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Giant multilevel cation channels formed by Alzheimer disease amyloid beta-protein [A beta P-(1-40)] in bilayer membranes

21 January 2018

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Amyloid beta protein (1-40) forms calcium-permeable, Zn2+-sensitive channel in reconstituted lipid vesicles

21 January 2018

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Theoretical models of the ion channel structure of amyloid beta-protein

21 January 2018

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Alterations in the ryanodine receptor calcium release channel correlate with Alzheimer's disease neurofibrillary and beta-amyloid pathologies.

21 January 2018

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Oxidative stress hypothesis in Alzheimer's disease

21 January 2018

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Alzheimer's disease and oxidative stress: implications for novel therapeutic approaches

21 January 2018

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Production of reactive oxygen species from aggregating proteins implicated in Alzheimer's disease, Parkinson's disease and other neurodegenerative diseases

21 January 2018

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Neuroprotective potential of aromatic alcohols against oxidative cell death

21 January 2018

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Vitamin E protects nerve cells from amyloid beta protein toxicity

21 January 2018

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The Ginkgo biloba extract (EGb 761) protects and rescues hippocampal cells against nitric oxide-induced toxicity: involvement of its flavonoid constituents and protein kinase C.

21 January 2018

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Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer's disease

21 January 2018

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Amphiphilic alpha-tocopherol analogues as inhibitors of brain lipid peroxidation.

21 January 2018

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Estrogen deficiency and risk of Alzheimer's disease in women.

21 January 2018

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Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides

21 January 2018

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Estrogen replacement therapy for treatment of mild to moderate Alzheimer disease: a randomized controlled trial. Alzheimer's Disease Cooperative Study

21 January 2018

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Testosterone reduces neuronal secretion of Alzheimer's beta-amyloid peptides

21 January 2018

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Testosterone-mediated neuroprotection through the androgen receptor in human primary neurons

21 January 2018

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Testosterone prevents the heat shock-induced overactivation of glycogen synthase kinase-3 beta but not of cyclin-dependent kinase 5 and c-Jun NH2-terminal kinase and concomitantly abolishes hyperphosphorylation of tau: implications for Alzheimer's d

21 January 2018

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An assessment of the antioxidant and the antiamyloidogenic properties of melatonin: implications for Alzheimer's disease

21 January 2018

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Inhibition of lipid peroxidation by N-acetylserotonin and its role in retinal physiology.

21 January 2018

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N-acetylserotonin is a better extra- and intracellular antioxidant than melatonin

21 January 2018

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N-acetylserotonin, melatonin and their derivatives improve cognition and protect against beta-amyloid-induced neurotoxicity.

21 January 2018

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Potent neuroprotective properties against the Alzheimer beta-amyloid by an endogenous melatonin-related indole structure, indole-3-propionic acid

21 January 2018

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Nuclear factor kappaB is a critical determinant in N-methyl-D-aspartate receptor-mediated neuroprotection

21 January 2018

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Apoptosis and the nervous system

21 January 2018

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A potential role for apoptosis in neurodegeneration and Alzheimer's disease

21 January 2018

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Is apoptosis key in Alzheimer's disease?

21 January 2018

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Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease

21 January 2018

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Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

21 January 2018

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Estrogen modulates neuronal Bcl-xL expression and beta-amyloid-induced apoptosis: relevance to Alzheimer's disease.

21 January 2018

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Role of mitochondria in neuronal apoptosis

21 January 2018

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Mitochondrial implication in accidental and programmed cell death: apoptosis and necrosis

21 January 2018

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Mitochondria and apoptosis

21 January 2018

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Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis

21 January 2018

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Neuronal apoptosis induced by pharmacological concentrations of 3-hydroxykynurenine: characterization and protection by dantrolene and Bcl-2 overexpression

21 January 2018

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Potentiation of NMDA receptor function through somatostatin release: a possible mechanism for the cognition-enhancing activity of GABA(B) receptor antagonists

21 January 2018

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Pharmacokinetics of MDL 26479, a novel benzodiazepine inverse agonist, in normal volunteers

21 January 2018

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Piracetam improves cognitive performance by restoring neurochemical deficits of the aged rat brain.

21 January 2018

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Monoamine oxidase-B inhibitors in the treatment of Alzheimer's disease

21 January 2018

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Neuroprotection against N-methyl-D-aspartate-induced excitotoxicity in rat magnocellular nucleus basalis by the 5-HT1A receptor agonist 8-OH-DPAT.

21 January 2018

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Acceleration of phosphatidylcholine synthesis and breakdown by inhibitors of mitochondrial function in neuronal cells: a model of the membrane defect of Alzheimer's disease.

21 January 2018

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Effect of a memory-enhancing drug, AIT-082, on the level of synaptophysin

21 January 2018

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Sustained improvements in patients with dementia of Alzheimer's type (DAT) 6 months after termination of Cerebrolysin therapy.

21 January 2018

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A double-blind, placebo-controlled, multicenter study of Cerebrolysin for Alzheimer's disease

21 January 2018

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Neurodegenerative tauopathies

21 January 2018

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Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

21 January 2018

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The molecular bases of Alzheimer's disease and other neurodegenerative disorders

21 January 2018

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Role of protein phosphatase-2A and -1 in the regulation of GSK-3, cdk5 and cdc2 and the phosphorylation of tau in rat forebrain.

21 January 2018

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Lithium reduces tau phosphorylation: effects in living cells and in neurons at therapeutic concentrations.

21 January 2018

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Alzheimer's disease and inflammation: a review of cellular and therapeutic mechanisms

21 January 2018

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Inflammation and Alzheimer's disease

21 January 2018

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Anti-inflammatory substances - a new therapeutic option in Alzheimer's disease

21 January 2018

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Maturational regulation and regional induction of cyclooxygenase-2 in rat brain: implications for Alzheimer's disease.

21 January 2018

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Cyclooxygenase inhibitors--current status and future prospects

21 January 2018

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A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

21 January 2018

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Putative role of neuronal 5-lipoxygenase in an aging brain.

21 January 2018

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A randomized controlled trial of prednisone in Alzheimer's disease. Alzheimer's Disease Cooperative Study.

21 January 2018

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Pilot tolerability studies of hydroxychloroquine and colchicine in Alzheimer disease

21 January 2018

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Immunophilins: beyond immunosuppression

21 January 2018

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Significance of melatonin in antioxidative defense system: reactions and products

21 January 2018

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Citicoline protects hippocampal neurons against apoptosis induced by brain beta-amyloid deposits plus cerebral hypoperfusion in rats

21 January 2018

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Determinants of neuronal vulnerability in neurodegenerative diseases.

21 January 2018

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Brain selective inhibition of acetylcholinesterase: a novel approach to therapy for Alzheimer's disease.

21 January 2018

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Cholinergic activity and amyloid precursor protein metabolism

21 January 2018

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Protective actions of L-carnitine and acetyl-L-carnitine on the neurotoxicity evoked by mitochondrial uncoupling or inhibitors

21 January 2018

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Metabotropic glutamate receptor subtype mGluR1alpha stimulates the secretion of the amyloid beta-protein precursor ectodomain.

21 January 2018

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Statins as a newly recognized type of immunomodulator

21 January 2018

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Arrest of beta-amyloid fibril formation by a pentapeptide ligand

21 January 2018

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Alzheimer's beta-amyloid peptide is conformationally modified by apolipoprotein E in vitro.

21 January 2018

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Apolipoprotein E promotes the binding and uptake of beta-amyloid into Chinese hamster ovary cells in an isoform-specific manner

21 January 2018

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Neuropharmacology of AMPA and kainate receptors

21 January 2018

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Calcium hypothesis of Alzheimer's disease and brain aging.

21 January 2018

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Presenilins, the endoplasmic reticulum, and neuronal apoptosis in Alzheimer's disease.

21 January 2018

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A preliminary open trial with nimodipine in patients with cognitive impairment and leukoaraiosis.

21 January 2018

1 reference

On the antioxidant activity of melatonin

21 January 2018

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Progression of neurofibrillary changes and PHF-tau in end-stage Alzheimer's disease is different from plaque and cortical microglial pathology

21 January 2018

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Oxidative damage in the central nervous system: protection by melatonin

21 January 2018

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Janus faces of NF-kappa B: neurodestruction versus neuroprotection

21 January 2018

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Glutamate-induced neuron death requires mitochondrial calcium uptake

21 January 2018

1 reference

Anticonvulsants attenuate amyloid beta-peptide neurotoxicity, Ca2+ deregulation, and cytoskeletal pathology

21 January 2018

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Pharmacology of cizolirtine: a new analgesic agent

21 January 2018

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No effect of anti-leprosy drugs in the prevention of Alzheimer's disease and beta-amyloid neurotoxicity

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/MED.10026

1 reference

5 August 2017

1 reference

PubMed ID

12424753