(Q34998222)

5 August 2017

title

DNA binding restricts the intrinsic conformational flexibility of methyl CpG binding protein 2 (MeCP2). (English)

1 reference

5 August 2017

Jeffrey C Hansen

1

1 reference

5 August 2017

Brian B Wexler

2

1 reference

5 August 2017

Danielle J Rogers

3

1 reference

5 August 2017

Kristopher C Hite

4

1 reference

5 August 2017

Tanya Panchenko

5

1 reference

5 August 2017

Sandya Ajith

6

1 reference

5 August 2017

Ben E Black

7

1 reference

5 August 2017

language of work or name

English

0 references

publication date

4 April 2011

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5 August 2017

number of pages

11

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Journal of Biological Chemistry

inferred from page(s)

published in

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5 August 2017

volume

286

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5 August 2017

issue

21

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5 August 2017

page(s)

18938-18948

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Binding of the Rett syndrome protein, MeCP2, to methylated and unmethylated DNA and chromatin.

5 August 2017

cites work

1 reference

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The structure of (CENP-A-H4)(2) reveals physical features that mark centromeres

8 July 2018

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MeCP2 binds cooperatively to its substrate and competes with histone H1 for chromatin binding sites

8 July 2018

1 reference

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Unique physical properties and interactions of the domains of methylated DNA binding protein 2.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099709

Neuronal MeCP2 is expressed at near histone-octamer levels and globally alters the chromatin state.

8 July 2018

1 reference

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What are pharmacological chaperones and why are they interesting?

8 July 2018

1 reference

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Recent advances in MeCP2 structure and function

8 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099709

Linking folding and binding

8 July 2018

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Malleable machines take shape in eukaryotic transcriptional regulation

8 July 2018

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Function and structure of inherently disordered proteins

8 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099709

MeCP2, a key contributor to neurological disease, activates and represses transcription

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099709

Rett syndrome-causing mutations in human MeCP2 result in diverse structural changes that impact folding and DNA interactions.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099709

Analysis of protein domains and Rett syndrome mutations indicate that multiple regions influence chromatin-binding dynamics of the chromatin-associated protein MECP2 in vivo

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099709

MeCP2 binding to DNA depends upon hydration at methyl-CpG

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099709

Integrated epigenomic analyses of neuronal MeCP2 reveal a role for long-range interaction with active genes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099709

MeCP2 interacts with HP1 and modulates its heterochromatin association during myogenic differentiation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099709

Intrinsic disorder and autonomous domain function in the multifunctional nuclear protein, MeCP2.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099709

An epigenetic mark generated by the incorporation of CENP-A into centromeric nucleosomes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099709

Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099709

Hydrogen exchange and mass spectrometry: A historical perspective

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099709

Molecular genetics of Rett syndrome: when DNA methylation goes unrecognized

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099709

MeCP2 dysfunction in Rett syndrome and related disorders

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099709

Rett syndrome: a Rosetta stone for understanding the molecular pathogenesis of autism

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099709

Intrinsic protein disorder, amino acid composition, and histone terminal domains.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099709

Regulation of RNA splicing by the methylation-dependent transcriptional repressor methyl-CpG binding protein 2.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099709

Structure and properties of alpha-synuclein and other amyloids determined at the amino acid level

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099709

Methyl-CpG-binding proteins in cancer: blaming the DNA methylation messenger

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099709

Intrinsically unstructured proteins and their functions

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099709

Brahma links the SWI/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencing

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099709

Components of the DNA methylation system of chromatin control are RNA-binding proteins

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099709

Structural determinants for generating centromeric chromatin

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099709

Rapid refinement of crystallographic protein construct definition employing enhanced hydrogen/deuterium exchange MS.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099709

Chromatin compaction by human MeCP2. Assembly of novel secondary chromatin structures in the absence of DNA methylation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099709

The affinity of different MBD proteins for a specific methylated locus depends on their intrinsic binding properties

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099709

Methyl-CpG-binding protein, MeCP2, is a target molecule for maintenance DNA methyltransferase, Dnmt1

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099709

The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099709

Intrinsic disorder and protein function

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099709

The Ski protein family is required for MeCP2-mediated transcriptional repression

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099709

The solution structure of the domain from MeCP2 that binds to methylated DNA

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099709

Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099709

Utilizing the C-terminal cleavage activity of a protein splicing element to purify recombinant proteins in a single chromatographic step

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099709

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099709

Crystal structure of the lactose operon repressor and its complexes with DNA and inducer

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099709

Dissection of the methyl-CpG binding domain from the chromosomal protein MeCP2

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099709

Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099709

Multiple modes of interaction between the methylated DNA binding protein MeCP2 and chromatin.

8 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.234609

Direct association between PU.1 and MeCP2 that recruits mSin3A-HDAC complex for PU.1-mediated transcriptional repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.234609

Phosphorylation driven motions in the COOH-terminal Src kinase, CSK, revealed through enhanced hydrogen-deuterium exchange and mass spectrometry (DXMS).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.234609

Structure and flexibility adaptation in nonspecific and specific protein-DNA complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.234609

Expansion of time window for mass spectrometric measurement of amide hydrogen/deuterium exchange reactions

21 January 2018

1 reference

12 December 2020

The general affinity of lac repressor for E. coli DNA: Implications for gene regulation in procaryotes and eucaryotes

1 reference

12 December 2020

The methyl-CpG-binding protein MECP2 is required for prostate cancer cell growth

1 reference

12 December 2020

MeCP2-chromatin interactions include the formation of chromatosome-like structures and are altered in mutations causing Rett syndrome

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M111.234609

1 reference

release_hoyy76xuenc7dclelecjjvjaz4

5 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/hoyy76xuenc7dclelecjjvjaz4

24 November 2022

mapped directly with Wikidata item

PMC publication ID

3099709

1 reference

5 August 2017

1 reference