(Q35001188)

English

Defective hydrophobic sliding mechanism and active site expansion in HIV-1 protease drug resistant variant Gly48Thr/Leu89Met: mechanisms for the loss of saquinavir binding potency

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scholarly article

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Europe PubMed Central

5 August 2017

Defective hydrophobic sliding mechanism and active site expansion in HIV-1 protease drug resistant variant Gly48Thr/Leu89Met: mechanisms for the loss of saquinavir binding potency (English)

1 reference

Europe PubMed Central

5 August 2017

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based on heuristic

inferred from title

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inferred from title

5

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11 June 2020

Adrian Roitberg

10

object named as

Adrian Roitberg

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11 June 2020

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Nathan E Goldfarb

1

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11 June 2020

Meray Ohanessian

2

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11 June 2020

Shyamasri Biswas

3

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11 June 2020

T Dwight McGee

4

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11 June 2020

David A Ostrov

6

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11 June 2020

Jose Garcia

7

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11 June 2020

Yan Tang

8

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11 June 2020

Robert McKenna

9

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11 June 2020

Ben M Dunn

11

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11 June 2020

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7 January 2015

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5 August 2017

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11 June 2020

54

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11 June 2020

2

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11 June 2020

422-433

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11 June 2020

PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data

1 reference

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8 July 2018

Significantly improved HIV inhibitor efficacy prediction employing proteochemometric models generated from antivirogram data

1 reference

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8 July 2018

Routine Access to Millisecond Time Scale Events with Accelerated Molecular Dynamics

1 reference

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8 July 2018

Handling ligands with Coot

1 reference

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8 July 2018

Hydrophobic Core Flexibility Modulates Enzyme Activity in HIV-1 Protease

1 reference

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8 July 2018

HIV-1 Protease: Structural Perspectives on Drug Resistance

1 reference

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Overview of the CCP4 suite and current developments

1 reference

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8 July 2018

HIV-1 protease mutations and protease inhibitor cross-resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303317

8 July 2018

Fragment-Based Screen against HIV Protease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303317

8 July 2018

PHENIX: a comprehensive Python-based system for macromolecular structure solution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303317

8 July 2018

Nonpolymorphic human immunodeficiency virus type 1 protease and reverse transcriptase treatment-selected mutations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303317

8 July 2018

Update of the Drug Resistance Mutations in HIV-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303317

8 July 2018

Mutational patterns and correlated amino acid substitutions in the HIV-1 protease after virological failure to nelfinavir- and lopinavir/ritonavir-based treatments.

1 reference

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8 July 2018

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1 reference

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8 July 2018

HIV-1 subtype B protease and reverse transcriptase amino acid covariation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303317

8 July 2018

Hydrophobic sliding: a possible mechanism for drug resistance in human immunodeficiency virus type 1 protease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303317

8 July 2018

Atomic resolution crystal structures of HIV-1 protease and mutants V82A and I84V with saquinavir

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303317

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Comparison of multiple Amber force fields and development of improved protein backbone parameters

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303317

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CASTp: computed atlas of surface topography of proteins with structural and topographical mapping of functionally annotated residues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303317

8 July 2018

Analysis of HIV-1 CRF_01 A/E protease inhibitor resistance: structural determinants for maintaining sensitivity and developing resistance to atazanavir

1 reference

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8 July 2018

HIV-1 protease flaps spontaneously open and reclose in molecular dynamics simulations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303317

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Novel human immunodeficiency virus type 1 protease mutations potentially involved in resistance to protease inhibitors

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303317

8 July 2018

Coot: model-building tools for molecular graphics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303317

8 July 2018

Development and testing of a general amber force field

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303317

8 July 2018

Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303317

8 July 2018

Human immunodeficiency virus reverse transcriptase and protease sequence database

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303317

8 July 2018

Viability of a drug-resistant human immunodeficiency virus type 1 protease variant: structural insights for better antiviral therapy

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8 July 2018

Fast, efficient generation of high-quality atomic charges. AM1-BCC model: II. Parameterization and validation

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Evolution of primary protease inhibitor resistance mutations during protease inhibitor salvage therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303317

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1 reference

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1 reference

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VMD: visual molecular dynamics

1 reference

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The effect of high-dose saquinavir on viral load and CD4+ T-cell counts in HIV-infected patients.

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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Chimeric aspartic proteinases and active site binding

1 reference

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12 December 2020

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inferred from PubMed ID database lookup

Insight into analysis of interactions of saquinavir with HIV-1 protease in comparison between the wild-type and G48V and G48V/L90M mutants based on QM and QM/MM calculations

1 reference

https://pubmed.ncbi.nlm.nih.gov/25513833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/25513833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complete mutagenesis of the HIV-1 protease

1 reference

https://pubmed.ncbi.nlm.nih.gov/25513833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/25513833

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/BI501088E

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30 July 2022

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release_fh7a3kds3zcybcakr3xt7lsoc4

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30 July 2022

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mapped directly with Wikidata item

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https://api.fatcat.wiki/v0/release/fh7a3kds3zcybcakr3xt7lsoc4

30 July 2022

based on heuristic

mapped directly with Wikidata item

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https://api.fatcat.wiki/v0/release/fh7a3kds3zcybcakr3xt7lsoc4

30 July 2022

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