(Q36857092)

16 August 2017

1 reference

title

HIV-1 protease: structure, dynamics, and inhibition (English)

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16 August 2017

4

Irene T Weber

1 reference

16 August 2017

John M Louis

1

1 reference

PubMed ID

17586318

16 August 2017

Rieko Ishima

series ordinal

2

1 reference

PubMed ID

17586318

16 August 2017

Dennis A Torchia

series ordinal

3

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16 August 2017

1 January 2007

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16 August 2017

Advances in Pharmacology

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16 August 2017

55

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16 August 2017

261-298

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Synthetic "interface" peptides alter dimeric assembly of the HIV 1 and 2 proteases

16 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Sequence-specific resonance assignments of the 1H-NMR spectra and structural characterization in solution of the HIV-1 transframe protein p6.

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Novel strategies for targeting the dimerization interface of HIV protease with cross-linked interfacial peptides

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Identification of the minimal conserved structure of HIV-1 protease in the presence and absence of drug pressure.

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Molecular dynamics simulations of 14 HIV protease mutants in complexes with indinavir

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Characterization of human immunodeficiency virus type-1 (HIV-1) particles that express protease-reverse transcriptase fusion proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Mutagenesis of the dimer interface residues of tethered and untethered HIV-1 protease result in differential activity and suggest multiple mechanisms of compensation

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Flap opening in HIV-1 protease simulated by 'activated' molecular dynamics.

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Subsite preferences of retroviral proteinases

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Structural mechanisms of HIV drug resistance

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Rapid structural fluctuations of the free HIV protease flaps in solution: relationship to crystal structures and comparison with predictions of dynamics calculations

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Two-step binding mechanism for HIV protease inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Structure-based design of novel HIV-1 protease inhibitors to combat drug resistance

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Use of protein unfolding studies to determine the conformational and dimeric stabilities of HIV-1 and SIV proteases

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Energy calculations and analysis of HIV-1 protease-inhibitor crystal structures

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Domain communication in the dynamical structure of human immunodeficiency virus 1 protease

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Fast peptidyl cis-trans isomerization within the flexible Gly-rich flaps of HIV-1 protease

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

HIV-1 protease flaps spontaneously open and reclose in molecular dynamics simulations

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Extending the range of amide proton relaxation dispersion experiments in proteins using a constant-time relaxation-compensated CPMG approach

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Error estimation and global fitting in transverse-relaxation dispersion experiments to determine chemical-exchange parameters.

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Flap opening and dimer-interface flexibility in the free and inhibitor-bound HIV protease, and their implications for function

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Folded monomer of HIV-1 protease

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Characterization of two hydrophobic methyl clusters in HIV-1 protease by NMR spin relaxation in solution

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Solution structure of the mature HIV-1 protease monomer: insight into the tertiary fold and stability of a precursor

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Carbonyl carbon transverse relaxation dispersion measurements and ms-micros timescale motion in a protein hydrogen bond network

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

A solution NMR study of the binding kinetics and the internal dynamics of an HIV-1 protease-substrate complex

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Molecular mechanisms for the conversion of zymogens to active proteolytic enzymes

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Structural and thermodynamic basis for the binding of TMC114, a next-generation human immunodeficiency virus type 1 protease inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI) UIC-94017 (TMC114) with potent activity against multi-PI-resistant human immunodeficiency virus in vitro.

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Ultra-high resolution crystal structure of HIV-1 protease mutant reveals two binding sites for clinical inhibitor TMC114

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Effectiveness of nonpeptide clinical inhibitor TMC-114 on HIV-1 protease with highly drug resistant mutations D30N, I50V, and L90M.

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Novel binding mode of highly potent HIV-proteinase inhibitors incorporating the (R)-hydroxyethylamine isostere

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Cyclic HIV protease inhibitors: synthesis, conformational analysis, P2/P2' structure-activity relationship, and molecular recognition of cyclic ureas

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

X-ray analysis of HIV-1 proteinase at 2.7 A resolution confirms structural homology among retroviral enzymes

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Standardized and simplified nomenclature for proteins common to all retroviruses

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

In vivo processing of Pr160gag-pol from human immunodeficiency virus type 1 (HIV) in acutely infected, cultured human T-lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S.

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Mechanism of drug resistance revealed by the crystal structure of the unliganded HIV-1 protease with F53L mutation

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Substitution mutations of the highly conserved arginine 87 of HIV-1 protease result in loss of proteolytic activity

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Kinetics and mechanism of autoprocessing of human immunodeficiency virus type 1 protease from an analog of the Gag-Pol polyprotein

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Hydrophilic peptides derived from the transframe region of Gag-Pol inhibit the HIV-1 protease

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

1 reference

7 January 2021

Proteolytic processing of HIV-1 protease precursor, kinetics and mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

HIV-1 protease: maturation, enzyme specificity, and drug resistance.

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Revisiting monomeric HIV-1 protease. Characterization and redesign for improved properties

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Structural and kinetic analysis of drug resistant mutants of HIV-1 protease

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Structural implications of drug-resistant mutants of HIV-1 protease: high-resolution crystal structures of the mutant protease/substrate analogue complexes

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Crystal structures of HIV protease V82A and L90M mutants reveal changes in the indinavir-binding site

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

New constrained "molecular tongs" designed to dissociate HIV-1 protease dimer

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

The HIV-1 protease as enzyme and substrate: mutagenesis of autolysis sites and generation of a stable mutant with retained kinetic properties.

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Structure of complex of synthetic HIV-1 protease with a substrate-based inhibitor at 2.3 A resolution

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

A major role for a set of non-active site mutations in the development of HIV-1 protease drug resistance

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Three-dimensional structure of aspartyl protease from human immunodeficiency virus HIV-1

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Flexibility and function in HIV-1 protease

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Adaptive inhibitors of the HIV-1 protease

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Thermodynamic rules for the design of high affinity HIV-1 protease inhibitors with adaptability to mutations and high selectivity towards unwanted targets

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Retroviral proteinases

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Competitive inhibition of human immunodeficiency virus type-1 protease by the Gag-Pol transframe protein

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

The active site of aspartic proteinases

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

A structural model for the retroviral proteases.

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

HIV-1 protease molecular dynamics of a wild-type and of the V82F/I84V mutant: possible contributions to drug resistance and a potential new target site for drugs

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Initial cleavage of the human immunodeficiency virus type 1 GagPol precursor by its activated protease occurs by an intramolecular mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Ordered processing of the human immunodeficiency virus type 1 GagPol precursor is influenced by the context of the embedded viral protease

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

How does a symmetric dimer recognize an asymmetric substrate? A substrate complex of HIV-1 protease

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Substrate shape determines specificity of recognition for HIV-1 protease: analysis of crystal structures of six substrate complexes

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Viability of a drug-resistant human immunodeficiency virus type 1 protease variant: structural insights for better antiviral therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Structural basis for coevolution of a human immunodeficiency virus type 1 nucleocapsid-p1 cleavage site with a V82A drug-resistant mutation in viral protease

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Mechanism of substrate recognition by drug-resistant human immunodeficiency virus type 1 protease variants revealed by a novel structural intermediate

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Reaction path and free energy calculations of the transition between alternate conformations of HIV-1 protease

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Inhibitor binding to the Phe53Trp mutant of HIV-1 protease promotes conformational changes detectable by spectrofluorometry.

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

HIV protease inhibition: limited recent progress and advances in understanding current pitfalls

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Domain flexibility in retroviral proteases: structural implications for drug resistant mutations

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

HIV-1 reproduction is inhibited by peptides derived frm the N- and C-termini of HIV-1 protease

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

The inhibition of human immunodeficiency virus proteases by 'interface peptides'.

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Lipopeptides as dimerization inhibitors of HIV-1 protease

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Curling of flap tips in HIV-1 protease as a mechanism for substrate entry and tolerance of drug resistance

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Genotypic testing for human immunodeficiency virus type 1 drug resistance

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Probing the role of interfacial residues in a dimerization inhibitor of HIV-1 protease

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Modulation of the oligomeric structures of HIV-1 retroviral enzymes by synthetic peptides and small molecules

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Proteolytic processing of an HIV-1 pol polyprotein precursor: insights into the mechanism of reverse transcriptase p66/p51 heterodimer formation

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Systematic mutational analysis of the active-site threonine of HIV-1 proteinase: rethinking the "fireman's grip" hypothesis

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Conformational stability and catalytic activity of HIV-1 protease are both enhanced at high salt concentration

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Current status of antiretroviral therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

High resolution crystal structures of HIV-1 protease with a potent non-peptide inhibitor (UIC-94017) active against multi-drug-resistant clinical strains

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs.

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

The structural stability of the HIV-1 protease

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Specificity of retroviral proteases: an analysis of viral and nonviral protein substrates

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Activity of tethered human immunodeficiency virus 1 protease containing mutations in the flap region of one subunit

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

A modular approach to HIV-1 proteinase inhibitor design

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Thermodynamic dissection of the binding energetics of KNI-272, a potent HIV-1 protease inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

HIV-1 protease inhibitors: enthalpic versus entropic optimization of the binding affinity.

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Database of three-dimensional structures of HIV proteinases

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Mapping hydration water molecules in the HIV-1 protease/DMP323 complex in solution by NMR spectroscopy.

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Crystallographic analysis of human immunodeficiency virus 1 protease with an analog of the conserved CA-p2 substrate -- interactions with frequently occurring glutamic acid residue at P2' position of substrates

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Structure-based inhibitors of HIV-1 protease

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Inhibitors of HIV-1 protease: a major success of structure-assisted drug design

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Conserved folding in retroviral proteases: crystal structure of a synthetic HIV-1 protease

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

A transient precursor of the HIV-1 protease. Isolation, characterization, and kinetics of maturation.

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Secondary structure and signal assignments of human-immunodeficiency-virus-1 protease complexed to a novel, structure-based inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Three-dimensional solution structure of the HIV-1 protease complexed with DMP323, a novel cyclic urea-type inhibitor, determined by nuclear magnetic resonance spectroscopy

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

Molecular dynamics simulation of HIV-1 protease in a crystalline environment and in solution

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2807%2955008-8

7 January 2021

10.1016/S1054-3589(07)55008-8

Identifiers

DOI

1 reference

16 August 2017

1 reference

PubMed ID

17586318