(Q35002998)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505181%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

title

The H50Q mutation induces a 10-fold decrease in the solubility of α-synuclein (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505181%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505181%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Christopher A Waudby

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505181%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Benedetta Bolognesi

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505181%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Julian Paton

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505181%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Stephen Mullin

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505181%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Guglielmo Verona

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505181%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Michele Vendruscolo

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505181%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Gian Gaetano Tartaglia

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505181%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Carlo Camilloni

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505181%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

17

Anthony H V Schapira

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505181%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

author name string

Riccardo Porcari

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505181%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

P Patrizia Mangione

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505181%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Lisa D Cabrita

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505181%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Amanda Penco

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505181%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Annalisa Relini

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505181%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Monica Stoppini

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505181%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

John Christodoulou

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505181%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Vittorio Bellotti

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505181%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

language of work or name

English

0 references

publication date

10 December 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505181%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

25 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505181%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

volume

290

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505181%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505181%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

page(s)

2395-2404

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505181%20AND%20SRC:MED&resulttype=core&format=json

The H50Q mutation enhances α-synuclein aggregation, secretion, and toxicity

25 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303689

Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303689

Residue histidine 50 plays a key role in protecting α-synuclein from aggregation at physiological pH.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303689

Widespread aggregation and neurodegenerative diseases are associated with supersaturated proteins

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303689

Principles of self-organization in biological pathways: a hypothesis on the autogenous association of alpha-synuclein

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303689

In-cell NMR characterization of the secondary structure populations of a disordered conformation of α-synuclein within E. coli cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303689

Atomic structure and hierarchical assembly of a cross- amyloid fibril

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303689

Site-specific perturbations of alpha-synuclein fibril structure by the Parkinson's disease associated mutations A53T and E46K

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303689

Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303689

A novel α-synuclein missense mutation in Parkinson disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303689

α-Synuclein in Parkinson's disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303689

α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303689

The A53T mutation is key in defining the differences in the aggregation kinetics of human and mouse α-synuclein

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303689

Structured regions of α-synuclein fibrils include the early-onset Parkinson's disease mutation sites.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303689

NMR determination of pKa values in α-synuclein

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303689

Allelic imbalance of expression and epigenetic regulation within the alpha-synuclein wild-type and p.Ala53Thr alleles in Parkinson disease.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303689

The interaction of alphaB-crystallin with mature alpha-synuclein amyloid fibrils inhibits their elongation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303689

An analytical solution to the kinetics of breakable filament assembly

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303689

alpha-Synuclein and neuronal cell death

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303689

The Zyggregator method for predicting protein aggregation propensities

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303689

The fold of alpha-synuclein fibrils

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303689

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303689

Molecular-level secondary structure, polymorphism, and dynamics of full-length alpha-synuclein fibrils studied by solid-state NMR.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303689

Prediction of "aggregation-prone" and "aggregation-susceptible" regions in proteins associated with neurodegenerative diseases

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303689

The CCPN data model for NMR spectroscopy: development of a software pipeline

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303689

Release of long-range tertiary interactions potentiates aggregation of natively unstructured alpha-synuclein

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303689

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303689

alpha-Synuclein locus triplication causes Parkinson's disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303689

Haploinsufficiency at the alpha-synuclein gene underlies phenotypic severity in familial Parkinson's disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303689

Alpha-synuclein and neurodegenerative diseases

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303689

alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303689

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303689

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303689

Alpha-synuclein in Lewy bodies

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303689

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303689

NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303689

1H, 13C and 15N chemical shift referencing in biomolecular NMR

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303689

NMRPipe: a multidimensional spectral processing system based on UNIX pipes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303689

Periodicity of polar and nonpolar amino acids is the major determinant of secondary structure in self-assembling oligomeric peptides

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303689

Hydrophobicity of amino acid residues in globular proteins.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303689

Fluorometric determination of amyloid fibrils in vitro using the fluorescent dye, thioflavin T1.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303689

Surface and inside volumes in globular proteins

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303689

Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease

8 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.610527

Neurodegenerative disease: amyloid pores from pathogenic mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.610527

Conformational properties of alpha-synuclein in its free and lipid-associated states

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.610527

The Parkinson's disease-associated H50Q mutation accelerates α-Synuclein aggregation in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.610527

Prediction of aggregation-prone regions in structured proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.610527

Dependence of alpha-synuclein aggregate morphology on solution conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.610527

Conformational stability of amyloid fibrils of beta2-microglobulin probed by guanidine-hydrochloride-induced unfolding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.610527

A set of BEST triple-resonance experiments for time-optimized protein resonance assignment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.610527

A relationship between the aggregation rates of α-synuclein variants and the β-sheet populations in their monomeric forms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.610527

Metastability of Native Proteins and the Phenomenon of Amyloid Formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.610527

Life on the edge: a link between gene expression levels and aggregation rates of human proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.610527

Prediction of Local Structural Stabilities of Proteins from Their Amino Acid Sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.610527

alpha-synuclein gene haplotypes are associated with Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.610527

Determination of Secondary Structure Populations in Disordered States of Proteins Using Nuclear Magnetic Resonance Chemical Shifts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.610527

Heteronuclear multidimensional NMR experiments for the structure determination of proteins in solution employing pulsed field gradients

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.610527

Mapping Long-Range Interactions in α-Synuclein using Spin-Label NMR and Ensemble Molecular Dynamics Simulations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.610527

Rapid Distinction of Intracellular and Extracellular Proteins Using NMR Diffusion Measurements

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.610527

Prediction of the Absolute Aggregation Rates of Amyloidogenic Polypeptide Chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.610527

Divergent effects of the H50Q and G51D SNCA mutations on the aggregation of α-synuclein

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25505181

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A theory of linear and helical aggregations of macromolecules

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25505181

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M114.610527

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505181%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505181%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

PubMed publication ID

25505181

1 reference