(Q34075948)

30 July 2017

title

Residue histidine 50 plays a key role in protecting α-synuclein from aggregation at physiological pH. (English)

1 reference

30 July 2017

1 reference

Ying-Chih Chi

1

1 reference

30 July 2017

Geoffrey S Armstrong

2

1 reference

30 July 2017

David N M Jones

3

1 reference

30 July 2017

Elan Z Eisenmesser

4

1 reference

30 July 2017

Chang-Wei Liu

5

1 reference

30 July 2017

language of work or name

English

0 references

publication date

17 April 2014

1 reference

Journal of Biological Chemistry

30 July 2017

published in

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30 July 2017

volume

289

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30 July 2017

issue

22

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30 July 2017

page(s)

15474-15481

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α-Synuclein as an intrinsically disordered monomer--fact or artefact?

30 July 2017

cites work

1 reference

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Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease.

5 July 2018

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A novel α-synuclein missense mutation in Parkinson disease

5 July 2018

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Structures of the E46K mutant-type α-synuclein protein and impact of E46K mutation on the structures of the wild-type α-synuclein protein

5 July 2018

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Role of C-terminal negative charges and tyrosine residues in fibril formation of α-synuclein.

5 July 2018

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A soluble α-synuclein construct forms a dynamic tetramer

5 July 2018

1 reference

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α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

5 July 2018

1 reference

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Role of different regions of alpha-synuclein in the assembly of fibrils.

5 July 2018

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A precipitating role for truncated alpha-synuclein and the proteasome in alpha-synuclein aggregation: implications for pathogenesis of Parkinson disease

5 July 2018

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The CCPN data model for NMR spectroscopy: development of a software pipeline

5 July 2018

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Release of long-range tertiary interactions potentiates aggregation of natively unstructured alpha-synuclein

5 July 2018

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The E46K mutation in alpha-synuclein increases amyloid fibril formation.

5 July 2018

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Mutation E46K increases phospholipid binding and assembly into filaments of human alpha-synuclein

5 July 2018

1 reference

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Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

5 July 2018

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Alpha-synuclein: normal function and role in neurodegenerative diseases.

5 July 2018

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The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

5 July 2018

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alpha-Synuclein locus triplication causes Parkinson's disease

5 July 2018

1 reference

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Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies

5 July 2018

1 reference

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Interaction of human alpha-Synuclein and Parkinson's disease variants with phospholipids. Structural analysis using site-directed mutagenesis.

5 July 2018

1 reference

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A Drosophila model of Parkinson's disease

5 July 2018

1 reference

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Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

5 July 2018

1 reference

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Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

5 July 2018

1 reference

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alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease

5 July 2018

1 reference

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Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation

5 July 2018

1 reference

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Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140903

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140903

Alpha-synuclein in Lewy bodies

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140903

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

5 July 2018

1 reference

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NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140903

NMRPipe: a multidimensional spectral processing system based on UNIX pipes

5 July 2018

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Identification of two distinct synucleins from human brain

5 July 2018

1 reference

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100 years of Lewy pathology

5 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.544049

Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.544049

The impact of the E46K mutation on the properties of alpha-synuclein in its monomeric and oligomeric states

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.544049

Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.544049

Role of alpha-synuclein carboxy-terminus on fibril formation in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.544049

Impact of the acidic C-terminal region comprising amino acids 109-140 on alpha-synuclein aggregation in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.544049

Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein(1-120): implications for Lewy body disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.544049

Selective loss of nigral dopamine neurons induced by overexpression of truncated human alpha-synuclein in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.544049

Ultra-high field NMR studies of antibody binding and site-specific phosphorylation of alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.544049

Impact of Tyr to Ala mutations on alpha-synuclein fibrillation and structural properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.544049

The Parkinson's disease-associated H50Q mutation accelerates α-Synuclein aggregation in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.544049

Mapping Long-Range Interactions in α-Synuclein using Spin-Label NMR and Ensemble Molecular Dynamics Simulations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.544049

Defining Long-Range Order and Local Disorder in Native α-Synuclein Using Residual Dipolar Couplings

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.544049

Familial Mutants of α-Synuclein with Increased Neurotoxicity Have a Destabilized Conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.544049

Causal relation between alpha-synuclein gene duplication and familial Parkinson's disease

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24742669

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Residual structure and dynamics in Parkinson's disease-associated mutants of alpha-synuclein

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24742669

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M113.544049

1 reference

30 July 2017

1 reference

30 July 2017

1 reference