(Q40433173)

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A precipitating role for truncated alpha-synuclein and the proteasome in alpha-synuclein aggregation: implications for pathogenesis of Parkinson disease

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scholarly article

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Europe PubMed Central

PubMed publication ID

20 September 2017

A precipitating role for truncated alpha-synuclein and the proteasome in alpha-synuclein aggregation: implications for pathogenesis of Parkinson disease (English)

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

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Parkinson's disease

1 reference

based on heuristic

inferred from title

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based on heuristic

inferred from title

author name string

Chang-Wei Liu

1

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

Benoit I Giasson

2

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

Karen A Lewis

3

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

Virginia M Lee

4

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

George N Demartino

5

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

Philip J Thomas

6

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

language of work or name

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publication date

19 April 2005

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

20 September 2017

280

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

24

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

22670-22678

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

Alpha-synuclein in Lewy bodies

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501508200

21 January 2018

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501508200

21 January 2018

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501508200

21 January 2018

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501508200

21 January 2018

Molecular Pathways of Neurodegeneration in Parkinson's Disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501508200

21 January 2018

Oxidative stress in neurodegeneration: cause or consequence?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501508200

21 January 2018

alpha-Synuclein locus triplication causes Parkinson's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501508200

21 January 2018

Nigrostriatal alpha-synucleinopathy induced by viral vector-mediated overexpression of human alpha-synuclein: a new primate model of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501508200

21 January 2018

alpha -Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501508200

21 January 2018

Yeast cells provide insight into alpha-synuclein biology and pathobiology

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501508200

21 January 2018

alpha-Synuclein is phosphorylated in synucleinopathy lesions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501508200

21 January 2018

Ubiquitination of alpha-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501508200

21 January 2018

The solubility of alpha-synuclein in multiple system atrophy differs from that of dementia with Lewy bodies and Parkinson's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501508200

21 January 2018

Synthetic filaments assembled from C-terminally truncated alpha-synuclein.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501508200

21 January 2018

Role of alpha-synuclein carboxy-terminus on fibril formation in vitro

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501508200

21 January 2018

Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501508200

21 January 2018

Annular alpha-synuclein protofibrils are produced when spherical protofibrils are incubated in solution or bound to brain-derived membranes.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501508200

21 January 2018

The latent form of macropain (high molecular weight multicatalytic protease) restores ATP-dependent proteolysis to soluble extracts of BHK fibroblasts pretreated with anti-macropain antibodies

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501508200

21 January 2018

Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501508200

21 January 2018

Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501508200

21 January 2018

Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501508200

21 January 2018

alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501508200

21 January 2018

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501508200

21 January 2018

Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501508200

21 January 2018

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501508200

21 January 2018

Overexpression of human alpha-synuclein causes dopamine neuron death in rat primary culture and immortalized mesencephalon-derived cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501508200

21 January 2018

Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501508200

21 January 2018

alpha-synuclein metabolism and aggregation is linked to ubiquitin-independent degradation by the proteasome

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501508200

21 January 2018

Endoproteolytic activity of the proteasome

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501508200

21 January 2018

Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501508200

21 January 2018

A broken alpha -helix in folded alpha -Synuclein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501508200

21 January 2018

Structure of membrane-bound alpha-synuclein studied by site-directed spin labeling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501508200

21 January 2018

Conformational properties of alpha-synuclein in its free and lipid-associated states

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501508200

21 January 2018

The proteasome, a novel protease regulated by multiple mechanisms

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501508200

21 January 2018

Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501508200

21 January 2018

Functional consequences of alpha-synuclein tyrosine nitration: diminished binding to lipid vesicles and increased fibril formation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501508200

21 January 2018

Lack of proteasome active site allostery as revealed by subunit-specific inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501508200

21 January 2018

Protein aggregation and neurodegenerative disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501508200

21 January 2018

Vesicle permeabilization by protofibrillar alpha-synuclein is sensitive to Parkinson's disease-linked mutations and occurs by a pore-like mechanism.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501508200

21 January 2018

The association of alpha-synuclein with membranes affects bilayer structure, stability, and fibril formation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501508200

21 January 2018

Aerolysin--the ins and outs of a model channel-forming toxin.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501508200

21 January 2018

A portrait of Alzheimer secretases--new features and familiar faces

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501508200

21 January 2018

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501508200

21 January 2018

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501508200

21 January 2018

α-Synuclein Is Degraded by Both Autophagy and the Proteasome

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501508200

21 January 2018

Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501508200

21 January 2018

Distinct cleavage patterns of normal and pathologic forms of alpha-synuclein by calpain I in vitro

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501508200

21 January 2018

Effects of Parkinson's disease-linked mutations on the structure of lipid-associated alpha-synuclein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501508200

21 January 2018

Accelerated alpha-synuclein fibrillation in crowded milieu

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501508200

21 January 2018

Impairment of the ubiquitin-proteasome system by protein aggregation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501508200

21 January 2018

Identifiers

10.1074/JBC.M501508200

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

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