(Q35003199)

5 August 2017

title

Hsp90 interacts with inducible NO synthase client protein in its heme-free state and then drives heme insertion by an ATP-dependent process (English)

1 reference

5 August 2017

2

Mamta Chawla-Sarkar

1 reference

5 August 2017

Arnab Ghosh

1

1 reference

5 August 2017

Dennis J Stuehr

series ordinal

3

1 reference

5 August 2017

language of work or name

English

0 references

publication date

25 February 2011

1 reference

5 August 2017

1 reference

5 August 2017

volume

25

1 reference

5 August 2017

issue

6

1 reference

5 August 2017

page(s)

2049-2060

1 reference

describes a project that uses

5 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3101027/fullTextXML

inferred from PubMed Central ID database lookup

cites work

GAPDH regulates cellular heme insertion into inducible nitric oxide synthase

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C331A mutant of neuronal nitric-oxide synthase is labilized for Hsp70/CHIP (C terminus of HSC70-interacting protein)-dependent ubiquitination

8 July 2018

1 reference

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ATP binding to Hsp90 is sufficient for effective chaperoning of p53 protein

8 July 2018

1 reference

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Hsp 70/Hsp 90 organizing protein as a nitrosylation target in cystic fibrosis therapy

8 July 2018

1 reference

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HSP90 at the hub of protein homeostasis: emerging mechanistic insights

8 July 2018

1 reference

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Discovery and development of Hsp90 inhibitors: a promising pathway for cancer therapy

8 July 2018

1 reference

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Proposal for a role of the Hsp90/Hsp70-based chaperone machinery in making triage decisions when proteins undergo oxidative and toxic damage

8 July 2018

1 reference

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Dual role of heat shock proteins as regulators of apoptosis and innate immunity

8 July 2018

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NO synthase: structures and mechanisms

8 July 2018

1 reference

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Nitric oxide blocks cellular heme insertion into a broad range of heme proteins

8 July 2018

1 reference

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Molecular mechanisms underlying the activation of eNOS.

8 July 2018

1 reference

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Strategies for stalling malignancy: targeting cancer's addiction to Hsp90.

8 July 2018

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Trafficking of heme and porphyrins in metazoa.

8 July 2018

1 reference

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Hsp90 is regulated by a switch point in the C-terminal domain

8 July 2018

1 reference

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Heat shock protein 90-eNOS interactions mature with postnatal age in the pulmonary circulation of the piglet.

8 July 2018

1 reference

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Functional characterization of the Shigella dysenteriae heme ABC transporter

8 July 2018

1 reference

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The Hsp90 chaperone machinery regulates signaling by modulating ligand binding clefts

8 July 2018

1 reference

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The Hsp90 chaperone machinery

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101027

HSP90: the Rosetta stone for cellular protein dynamics?

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101027

Heat shock protein 90 regulates stabilization rather than activation of soluble guanylate cyclase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101027

Functional significance of hsp90 complexes with NOS and sGC in endothelial cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101027

ABC transporter-mediated release of a haem chaperone allows cytochrome c biogenesis

8 July 2018

1 reference

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Interaction between the 90-kDa heat shock protein and soluble guanylyl cyclase: physiological significance and mapping of the domains mediating binding

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101027

Visualizing inducible nitric-oxide synthase in living cells with a heme-binding fluorescent inhibitor

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101027

S-nitrosylation of Hsp90 promotes the inhibition of its ATPase and endothelial nitric oxide synthase regulatory activities

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101027

Regulation of inducible nitric oxide synthase by rapid cellular turnover and cotranslational down-regulation by dimerization inhibitors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101027

The role of hsp90 in heme-dependent activation of apo-neuronal nitric-oxide synthase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101027

Update on mechanism and catalytic regulation in the NO synthases.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101027

Heat shock protein 90 as an endogenous protein enhancer of inducible nitric-oxide synthase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101027

Protein interactions with nitric oxide synthases: controlling the right time, the right place, and the right amount of nitric oxide

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101027

Proteolytic degradation of nitric oxide synthase: effect of inhibitors and role of hsp90-based chaperones

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101027

Inhibition of superoxide generation from neuronal nitric oxide synthase by heat shock protein 90: implications in NOS regulation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101027

Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101027

Acidic hydrolysis as a mechanism for the cleavage of the Glu(298)-->Asp variant of human endothelial nitric-oxide synthase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101027

A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101027

Guanabenz-mediated inactivation and enhanced proteolytic degradation of neuronal nitric-oxide synthase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101027

Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101027

Neuronal nitric-oxide synthase is regulated by the Hsp90-based chaperone system in vivo

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101027

Antifungal imidazoles block assembly of inducible NO synthase into an active dimer

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101027

Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101027

Dynamic activation of endothelial nitric oxide synthase by Hsp90.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101027

Characterization of the inducible nitric oxide synthase oxygenase domain identifies a 49 amino acid segment required for subunit dimerization and tetrahydrobiopterin interaction

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101027

Characterization of heme-deficient neuronal nitric-oxide synthase reveals a role for heme in subunit dimerization and binding of the amino acid substrate and tetrahydrobiopterin.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101027

Intracellular assembly of inducible NO synthase is limited by nitric oxide-mediated changes in heme insertion and availability

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101027

Understanding of the Hsp90 molecular chaperone reaches new heights.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101027

Dominant-negative Hsp90 reduces VEGF-stimulated nitric oxide release and migration in endothelial cells

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101027

A heat shock protein 90 binding domain in endothelial nitric-oxide synthase influences enzyme function

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101027

Nitric oxide and superoxide generation from endothelial NOS: modulation by HSP90.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101027

Structure of a loose dimer: an intermediate in nitric oxide synthase assembly

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101027

Ubiquitination and degradation of neuronal nitric-oxide synthase in vitro: dimer stabilization protects the enzyme from proteolysis

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101027

Mechanistic studies with potent and selective inducible nitric-oxide synthase dimerization inhibitors

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101027

Haem insertion, dimerization and reactivation of haem-free rat neuronal nitric oxide synthase.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101027

Heme insertion, assembly, and activation of apo-neuronal nitric-oxide synthase in vitro

26 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21357526

12 December 2020

inferred from PubMed ID database lookup

Macrophage nitric oxide synthase subunits. Purification, characterization, and role of prosthetic groups and substrate in regulating their association into a dimeric enzyme

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21357526

12 December 2020

inferred from PubMed ID database lookup

Surface charge interactions of the FMN module govern catalysis by nitric-oxide synthase

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21357526

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1096/FJ.10-180554

1 reference

5 August 2017

1 reference

5 August 2017

1 reference