(Q35003946)

5 August 2017

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title

Mouse models to study the role of telomeres in cancer, aging and DNA repair (English)

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5 August 2017

María A Blasco

1

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publication date

1 November 2002

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European Journal of Cancer

5 August 2017

published in

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5 August 2017

volume

38

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5 August 2017

issue

17

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5 August 2017

page(s)

2222-2228

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Switching and signaling at the telomere

5 August 2017

cites work

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7 January 2021

New ways not to make ends meet: telomerase, DNA damage proteins and heterochromatin

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7 January 2021

Protection of mammalian telomeres

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7 January 2021

Mammalian telomeres end in a large duplex loop

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7 January 2021

Many ways to telomere dysfunction: in vivo studies using mouse models

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7 January 2021

Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

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7 January 2021

Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres

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7 January 2021

Telomeric localization of TRF2, a novel human telobox protein

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7 January 2021

Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2

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7 January 2021

A human telomeric protein

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7 January 2021

Control of human telomere length by TRF1 and TRF2

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7 January 2021

Repression of the gene encoding the TGF-beta type II receptor is a major target of the EWS-FLI1 oncoprotein

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7 January 2021

Tankyrase, a poly(ADP-ribose) polymerase at human telomeres

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7 January 2021

TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression

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7 January 2021

Tankyrase promotes telomere elongation in human cells

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7 January 2021

TRF2 Protects Human Telomeres from End-to-End Fusions

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7 January 2021

p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2

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7 January 2021

Identification of human Rap1: implications for telomere evolution

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7 January 2021

Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres

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7 January 2021

The DNA-dependent protein kinase

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7 January 2021

Ku binds telomeric DNA in vitro

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7 January 2021

Ku is associated with the telomere in mammals

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7 January 2021

Ku acts in a unique way at the mammalian telomere to prevent end joining

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7 January 2021

Interaction of human Ku70 with TRF2

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7 January 2021

DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes

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7 January 2021

Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang

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7 January 2021

The absence of the dna-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang.

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7 January 2021

Strand-Specific Postreplicative Processing of Mammalian Telomeres

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7 January 2021

Pot1, the putative telomere end-binding protein in fission yeast and humans

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7 January 2021

Telomeres shorten during ageing of human fibroblasts

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7 January 2021

Telomerase in the human organism

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7 January 2021

Mammalian telomeres and telomerase

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7 January 2021

Essential role of mouse telomerase in highly proliferative organs

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7 January 2021

Disease states associated with telomerase deficiency appear earlier in mice with short telomeres

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7 January 2021

Restoration of telomerase activity rescues chromosomal instability and premature aging in Terc-/- mice with short telomeres.

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7 January 2021

The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability

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7 January 2021

Extension of life-span by introduction of telomerase into normal human cells

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7 January 2021

Clinical utility of telomerase in cancer

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7 January 2021

Telomeres: has cancer's Achilles' heel been exposed?

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7 January 2021

Emerging roles for telomerase in regulating cell differentiation and survival: a neuroscientist's perspective

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7 January 2021

Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines

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7 January 2021

Telomere maintenance by recombination in human cells.

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7 January 2021

Functional characterization and developmental regulation of mouse telomerase RNA.

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7 January 2021

Telomere shortening in mTR-/- embryos is associated with failure to close the neural tube

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7 January 2021

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

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7 January 2021

Impaired germinal center reaction in mice with short telomeres.

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7 January 2021

Long-term repopulating ability of telomerase-deficient murine hematopoietic stem cells

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7 January 2021

A survey of telomerase activity in human cancer

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7 January 2021

Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis.

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7 January 2021

p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis

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7 January 2021

Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

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7 January 2021

Telomere dysfunction and evolution of intestinal carcinoma in mice and humans

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7 January 2021

Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2802%2900450-1

7 January 2021

Short telomeres result in organismal hypersensitivity to ionizing radiation in mammals

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2802%2900450-1

7 January 2021

Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2802%2900450-1

7 January 2021

Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2802%2900450-1

7 January 2021

Telomerase activation in mouse mammary tumors: lack of detectable telomere shortening and evidence for regulation of telomerase RNA with cell proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2802%2900450-1

7 January 2021

Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2802%2900450-1

7 January 2021

Constitutive telomerase expression promotes mammary carcinomas in aging mice

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2802%2900450-1

7 January 2021

Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2802%2900450-1

7 January 2021

Deletion of Ku86 causes early onset of senescence in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2802%2900450-1

7 January 2021

DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2802%2900450-1

7 January 2021

10.1016/S0959-8049(02)00450-1

Identifiers

DOI

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5 August 2017

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