(Q35007278)

5 August 2017

title

Six amino acid residues in a 1200 Å2 interface mediate binding of factor VIII to an IgG4κ inhibitory antibody (English)

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5 August 2017

Jasper C Lin

1

1 reference

5 August 2017

Ruth A Ettinger

2

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5 August 2017

Jason T Schuman

3

1 reference

5 August 2017

Ai-Hong Zhang

4

1 reference

5 August 2017

Muhammad Wamiq-Adhami

5

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5 August 2017

Phuong-Cac T Nguyen

6

1 reference

5 August 2017

Shelley M Nakaya-Fletcher

7

1 reference

5 August 2017

Komal Puranik

8

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5 August 2017

Arthur R Thompson

9

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5 August 2017

Kathleen P Pratt

10

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5 August 2017

language of work or name

English

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publication date

23 January 2015

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5 August 2017

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5 August 2017

volume

10

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5 August 2017

issue

1

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5 August 2017

page(s)

e0116577

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Creative Commons CC0 License

5 August 2017

copyright license

start time

23 January 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted, dedicated to the public domain by copyright holder

0 references

cites work

High-resolution mapping of epitopes on the C2 domain of factor VIII by analysis of point mutants using surface plasmon resonance

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Structure of the factor VIII C2 domain in a ternary complex with 2 inhibitor antibodies reveals classical and nonclassical epitopes

8 July 2018

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Characterization and solution structure of the factor VIII C2 domain in a ternary complex with classical and non-classical inhibitor antibodies

8 July 2018

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Functional characteristics of the novel, human-derived recombinant FVIII protein product, human-cl rhFVIII.

8 July 2018

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Multimerization of peptide mimotopes for blocking of factor VIII neutralizing antibodies

8 July 2018

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Nonclassical anti-C2 domain antibodies are present in patients with factor VIII inhibitors

8 July 2018

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Antihuman factor VIII C2 domain antibodies in hemophilia A mice recognize a functionally complex continuous spectrum of epitopes dominated by inhibitors of factor VIII activation

8 July 2018

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The humoral response to human factor VIII in hemophilia A mice

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8 July 2018

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Drug-target residence time and its implications for lead optimization

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Epitope mapping factor VIII A2 domain by affinity-directed mass spectrometry: residues 497-510 and 584-593 comprise a discontinuous epitope for the monoclonal antibody R8B12.

8 July 2018

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New insights into binding interfaces of coagulation factors V and VIII and their homologues lessons from high resolution crystal structures

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Structure of a factor VIII C2 domain-immunoglobulin G4kappa Fab complex: identification of an inhibitory antibody epitope on the surface of factor VIII

8 July 2018

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Antigenicity of putative phospholipid membrane-binding residues in factor VIII.

8 July 2018

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Phage display technology: a tool to explore the diversity of inhibitors to blood coagulation factor VIII.

8 July 2018

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8 July 2018

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Structure of the C2 domain of human factor VIII at 1.5 A resolution

8 July 2018

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8 July 2018

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8 July 2018

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Mechanism and kinetics of factor VIII inactivation: study with an IgG4 monoclonal antibody derived from a hemophilia A patient with inhibitor

8 July 2018

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Forces contributing to the conformational stability of proteins

8 July 2018

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Recombinant factor VIII for the treatment of previously untreated patients with hemophilia A. Safety, efficacy, and development of inhibitors. Kogenate Previously Untreated Patient Study Group

8 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304825

Anti-factor VIII antibodies of hemophiliac patients are frequently directed towards nonfunctional determinants and do not exhibit isotypic restriction.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304825

A hot spot of binding energy in a hormone-receptor interface

8 July 2018

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Incidence of development of factor VIII and factor IX inhibitors in haemophiliacs

8 July 2018

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8 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304825

The safety and efficacy of B-domain deleted recombinant factor VIII concentrate in patients with severe haemophilia A.

8 July 2018

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Acquired hemophilia A in the United Kingdom: a 2-year national surveillance study by the United Kingdom Haemophilia Centre Doctors' Organisation.

21 January 2018

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A domain mutations in 65 haemophilia A families and molecular modelling of dysfunctional factor VIII proteins

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0116577

Use of affinity-directed liquid chromatography-mass spectrometry to map the epitopes of a factor VIII inhibitor antibody fraction

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0116577

Kinetics and thermodynamics of interaction of coagulation factor VIII with a pathogenic human antibody

21 January 2018

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A human FVIII inhibitor modulates FVIII surface electrostatics at a VWF-binding site distant from its epitope.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0116577

A thermodynamic characterization of the binding of thrombin inhibitors to human thrombin, combining biosensor technology, stopped-flow spectrophotometry, and microcalorimetry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0116577

Reduction of the inhibitory antibody response to human factor VIII in hemophilia A mice by mutagenesis of the A2 domain B-cell epitope

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0116577

Thermodynamic analysis of the interaction of factor VIII with von Willebrand factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0116577

Mutational analysis of thrombopoietin for identification of receptor and neutralizing antibody sites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0116577

Contributions of Asn2198, Met2199, and Phe2200 in the factor VIII C2 domain to cofactor activity, phospholipid-binding, and von Willebrand factor-binding

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304825

The preparation and phospholipid binding property of the C2 domain of human factor VIII

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304825

Some factor VIII inhibitor antibodies recognize a common epitope corresponding to C2 domain amino acids 2248 through 2312, which overlap a phospholipid-binding site.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304825

FVIII inhibitor IgG subclass and FVIII polypeptide specificity determined by immunoblotting

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304825

Comparison of a structural and a functional epitope

26 October 2018

1 reference

12 December 2020

Elimination of a major inhibitor epitope in factor VIII

1 reference

12 December 2020

Dissociation rate of antibody-gp120 binding interactions is predictive of V3-mediated neutralization of HIV-1

1 reference

12 December 2020

A mechanism for inhibition of factor VIII binding to phospholipid by von Willebrand factor

1 reference

12 December 2020

Immunodominant T-cell epitopes in the factor VIII C2 domain are located within an inhibitory antibody binding site

1 reference

12 December 2020

A synthetic factor VIII peptide of eight amino acid residues (1677-1684) contains the binding region of an anti-factor VIII antibody which inhibits the binding of factor VIII to von Willebrand factor

1 reference

12 December 2020

Epitope localization of monoclonal antibodies against factor VIII light chain which inhibit complex formation by factor VIII with von Willebrand factor

1 reference

12 December 2020

Factor VIII inhibitors in mild and moderate-severity haemophilia A. UK Haemophilia Centre Directors Organisation

1 reference

12 December 2020

Thermodynamic analysis of protein interactions with biosensor technology

1 reference

12 December 2020

A role for the C2 domain of factor VIII in binding to von Willebrand factor

1 reference

12 December 2020

Mechanism of the immune response to human factor VIII in murine hemophilia A

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0116577

Identifiers

DOI

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5 August 2017

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5 August 2017

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