(Q35013347)

5 August 2017

title

Molecular modeling of a tandem two pore domain potassium channel reveals a putative binding site for general anesthetics (English)

1 reference

5 August 2017

Nicholas P Franks

4

0 references

author name string

Edward J Bertaccini

series ordinal

1

1 reference

5 August 2017

Robert Dickinson

series ordinal

2

1 reference

5 August 2017

James R Trudell

series ordinal

3

1 reference

5 August 2017

publication date

31 October 2014

1 reference

ACS Chemical Neuroscience

5 August 2017

published in

1 reference

5 August 2017

volume

5

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5 August 2017

issue

12

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5 August 2017

page(s)

1246-1252

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Assessment of homology templates and an anesthetic binding site within the γ-aminobutyric acid receptor

5 August 2017

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1 reference

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8 July 2018

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8 July 2018

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8 July 2018

1 reference

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Crystal structure of the human two-pore domain potassium channel K2P1

8 July 2018

1 reference

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Covalent modification of a volatile anesthetic regulatory site activates TASK-3 (KCNK9) tandem-pore potassium channels

8 July 2018

1 reference

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Propofol anesthesia and sleep: a high-density EEG study

8 July 2018

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Motoneuronal TASK channels contribute to immobilizing effects of inhalational general anesthetics

8 July 2018

1 reference

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An unexpected role for TASK-3 potassium channels in network oscillations with implications for sleep mechanisms and anesthetic action

8 July 2018

1 reference

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8 July 2018

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Emerging roles for two-pore-domain potassium channels and their potential therapeutic impact

8 July 2018

1 reference

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Protein structure modeling with MODELLER

8 July 2018

1 reference

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General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal

8 July 2018

1 reference

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Determinants of the anesthetic sensitivity of two-pore domain acid-sensitive potassium channels: molecular cloning of an anesthetic-activated potassium channel from Lymnaea stagnalis

8 July 2018

1 reference

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Molecular targets underlying general anaesthesia

8 July 2018

1 reference

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The TREK K2P channels and their role in general anaesthesia and neuroprotection

8 July 2018

1 reference

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Molecular and neuronal substrates for general anaesthetics

8 July 2018

1 reference

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TREK-1, a K+ channel involved in neuroprotection and general anesthesia

8 July 2018

1 reference

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Two-pore-domain K+ channels are a novel target for the anesthetic gases xenon, nitrous oxide, and cyclopropane

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306477

Modulation of TASK-1 (Kcnk3) and TASK-3 (Kcnk9) potassium channels: volatile anesthetics and neurotransmitters share a molecular site of action

8 July 2018

1 reference

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Molecular and functional properties of two-pore-domain potassium channels.

8 July 2018

1 reference

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8 July 2018

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1 reference

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Inhalational anesthetics activate two-pore-domain background K+ channels

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306477

Structural basis for the inhibition of firefly luciferase by a general anesthetic

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306477

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306477

Using CLUSTAL for multiple sequence alignments

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306477

Do general anaesthetics act by competitive binding to specific receptors?

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306477

Volatile general anaesthetics activate a novel neuronal K+ current

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306477

An anaesthetic-activated potassium channel

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306477

The common chemical motifs within anesthetic binding sites

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306477

The in vivo contributions of TASK-1-containing channels to the actions of inhalation anesthetics, the alpha(2) adrenergic sedative dexmedetomidine, and cannabinoid agonists.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306477

General anesthetic actions in vivo strongly attenuated by a point mutation in the GABA(A) receptor beta3 subunit.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306477

Contrasting synaptic actions of the inhalational general anesthetics isoflurane and xenon.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306477

25 October 2018

Identifiers

DOI

10.1021/CN500172E

1 reference

5 August 2017

1 reference

5 August 2017

1 reference