(Q35015325)

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Novel analogues of chlormethiazole are neuroprotective in four cellular models of neurodegeneration by a mechanism with variable dependence on GABA(A) receptor potentiation

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scholarly article

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Europe PubMed Central

PubMed publication ID

5 August 2017

Novel analogues of chlormethiazole are neuroprotective in four cellular models of neurodegeneration by a mechanism with variable dependence on GABA(A) receptor potentiation (English)

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

neurodegeneration

1 reference

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author name string

Lawren Vandevrede

1

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Ehsan Tavassoli

2

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Jia Luo

3

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Zhihui Qin

4

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Lan Yue

5

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

David R Pepperberg

6

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Gregory R Thatcher

7

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

language of work or name

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publication date

1 January 2014

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

British Journal of Pharmacology

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Europe PubMed Central

PubMed publication ID

5 August 2017

171

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

389-402

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3904259/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

The Concise Guide to PHARMACOLOGY 2013/14: overview

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904259

8 July 2018

Robust photoregulation of GABA(A) receptors by allosteric modulation with a propofol analogue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904259

8 July 2018

Design and synthesis of neuroprotective methylthiazoles and modification as NO-chimeras for neurodegenerative therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904259

8 July 2018

Neurotoxicity of amyloid β-protein: synaptic and network dysfunction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904259

8 July 2018

Loss of functional GABA(A) receptors in the Alzheimer diseased brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904259

8 July 2018

Beyond classical benzodiazepines: novel therapeutic potential of GABAA receptor subtypes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904259

8 July 2018

Benzothiophene Selective Estrogen Receptor Modulators Provide Neuroprotection by a novel GPR30-dependent Mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904259

8 July 2018

Implications for treatment: GABAA receptors in aging, Down syndrome and Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904259

8 July 2018

Mitophagy in neurodegeneration: an opportunity for therapy?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904259

8 July 2018

EHT0202 in Alzheimer's disease: a 3-month, randomized, placebo-controlled, double-blind study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904259

8 July 2018

The rise of a new GABA pharmacology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904259

8 July 2018

Animal research: reporting in vivo experiments: the ARRIVE guidelines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904259

8 July 2018

Guidelines for reporting experiments involving animals: the ARRIVE guidelines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904259

8 July 2018

Endocytic pathways mediating oligomeric Abeta42 neurotoxicity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904259

8 July 2018

Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904259

8 July 2018

Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904259

8 July 2018

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904259

8 July 2018

The pharmacology of chlormethiazole: a potential neuroprotective agent?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904259

8 July 2018

Activity of chlormethiazole at human recombinant GABAA and NMDA receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904259

8 July 2018

In vitro characterization of conditions for amyloid-beta peptide oligomerization and fibrillogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904259

8 July 2018

Toward wisdom from failure: lessons from neuroprotective stroke trials and new therapeutic directions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904259

8 July 2018

GABA potentiation: a logical pharmacological approach for the treatment of acute ischaemic stroke

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904259

8 July 2018

Clinical trials with neuroprotective drugs in acute ischaemic stroke: are we doing the right thing?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904259

8 July 2018

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904259

8 July 2018

Attenuation by chlormethiazole administration of the rise in extracellular amino acids following focal ischaemia in the cerebral cortex of the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904259

8 July 2018

The effect of chlormethiazole on neuronal damage in a model of transient focal ischaemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904259

8 July 2018

The protective action of chlormethiazole against ischaemia‐induced neurodegeneration in gerbils when infused at doses having little sedative or anticonvulsant activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904259

8 July 2018

Drug interactions at the GABA receptor-ionophore complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904259

8 July 2018

The modulation by chlormethiazole of the GABAA-receptor complex in rat brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904259

8 July 2018

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904259

8 July 2018

Serum TNF-alpha levels are increased and correlate negatively with free IGF-I in Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1111%2FBPH.12454

21 January 2018

Mitochondrial involvement in transhemispheric diaschisis following hypoxia-ischemia: Clomethiazole-mediated amelioration.

1 reference

https://api.crossref.org/works/10.1111%2FBPH.12454

21 January 2018

Studies on the neuroprotective effect of the enantiomers of AR-A008055, a compound structurally related to clomethiazole, on MDMA ("ecstasy")-induced neurodegeneration in rat brain

1 reference

https://api.crossref.org/works/10.1111%2FBPH.12454

21 January 2018

Clomethiazole (ZENDRA, CMZ) improves hind limb motor function and reduces neuronal damage after severe spinal cord injury in rat.

1 reference

https://api.crossref.org/works/10.1111%2FBPH.12454

21 January 2018

Clomethiazole (Zendra) in acute ischemic stroke: basic pharmacology and biochemistry and clinical efficacy.

1 reference

https://api.crossref.org/works/10.1111%2FBPH.12454

21 January 2018

The interaction of AR-A008055 and its enantiomers with the GABA(A) receptor complex and their sedative, muscle relaxant and anticonvulsant activity.

1 reference

https://api.crossref.org/works/10.1111%2FBPH.12454

21 January 2018

The effect of clomethiazole on plasma concentrations of interleukin-6, -8, -1beta, tumor necrosis factor-alpha, and neutrophil adhesion molecule expression during experimental extracorporeal circulation

1 reference

https://api.crossref.org/works/10.1111%2FBPH.12454

21 January 2018

Effects of clomethiazole on radial-arm maze performance following global forebrain ischemia in gerbils.

1 reference

https://api.crossref.org/works/10.1111%2FBPH.12454

21 January 2018

Functional benefit from clomethiazole treatment after focal cerebral ischemia in a nonhuman primate species.

1 reference

https://api.crossref.org/works/10.1111%2FBPH.12454

21 January 2018

Neuroprotective efficacy of AR-A008055, a clomethiazole analogue, in a global model of acute ischaemic stroke and its effect on ischaemia-induced glutamate and GABA efflux in vitro.

1 reference

https://api.crossref.org/works/10.1111%2FBPH.12454

21 January 2018

The effects of chlormethiazole and nimodipine on cortical infarct area after focal cerebral ischaemia in the rat.

1 reference

https://api.crossref.org/works/10.1111%2FBPH.12454

21 January 2018

Clomethiazole acute stroke study (CLASS): results of a randomized, controlled trial of clomethiazole versus placebo in 1360 acute stroke patients.

1 reference

https://api.crossref.org/works/10.1111%2FBPH.12454

21 January 2018

Rosiglitazone induces mitochondrial biogenesis in mouse brain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904259

25 October 2018

Clomethiazole (Astra Arcus AB).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904259

25 October 2018

Clomethiazole: mechanisms underlying lasting neuroprotection following hypoxia-ischemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904259

25 October 2018

Clomethiazole: an unsuccessful bachelor, but perhaps a prosperous married man?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904259

25 October 2018

Chlormethiazole: neurochemical actions at the gamma-aminobutyric acid receptor complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-TNF-α reduces amyloid plaques and tau phosphorylation and induces CD11c-positive dendritic-like cell in the APP/PS1 transgenic mouse brains

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relations between chemical structure and physiological action of some thiazole derivatives. II. Influence of the length of the carbon chain attached at position 5 in 4-methyl-5-(omega-chloroalkyl)-thiazoles

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The neuroprotective effect of chlormethiazole on ischaemic neuronal damage following permanent middle cerebral artery ischaemia in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on hypnotic and anticonvulsant agents related to the thiazole part of thiamine

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Compounds related to clomethiazole. IV. 4-Methylthiazoles and oxazoles with polar side-chains and some other analogues of clomethiazole

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotection for acute stroke: making clinical trials work

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Results in 95 hemorrhagic stroke patients included in CLASS, a controlled trial of clomethiazole versus placebo in acute stroke patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clomethiazole protects against hemineglect in a primate model of stroke

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological study of a quaternary ammonium compound possessing preponderant ganglionic stimulating properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aβ oligomers induce glutamate release from hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RELATIONS BETWEEN CHEMICAL STRUCTURE AND PHYSIOLOGICAL ACTIVITY OF SOME THIAZOLE DERIVATIVES. I. CASE OF 4-METHYL BETA-HYDROXY-5-ETHYL THIAZOLE

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/BPH.12454

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

ResearchGate publication ID

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