(Q43698586)

English

The interaction of AR-A008055 and its enantiomers with the GABA(A) receptor complex and their sedative, muscle relaxant and anticonvulsant activity.

scientific article published in August 2001

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11489453%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

The interaction of AR-A008055 and its enantiomers with the GABA(A) receptor complex and their sedative, muscle relaxant and anticonvulsant activity (English)

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10 November 2019

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Atticus H Hainsworth

2

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10 November 2019

8

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10 November 2019

author name string

A R Green

1

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10 November 2019

A Misra

3

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10 November 2019

T A Debens

4

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10 November 2019

D M Jackson

5

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10 November 2019

T K Murray

6

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10 November 2019

R M Nelson

7

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10 November 2019

publication date

1 August 2001

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10 November 2019

Neuropharmacology

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10 November 2019

41

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10 November 2019

2

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10 November 2019

167-174

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10 November 2019

The protective action of chlormethiazole against ischaemia‐induced neurodegeneration in gerbils when infused at doses having little sedative or anticonvulsant activity

1 reference

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The modulation by chlormethiazole of the GABAA-receptor complex in rat brain

1 reference

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The pull-up test in rats: A simple method for evaluating muscle relaxation

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Anticonvulsant activity of the glial GABA uptake inhibitor, THAO, in chemical seizures

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Clomethiazole (Zendra) in acute ischemic stroke: basic pharmacology and biochemistry and clinical efficacy.

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A simple intravenous infusion method in rodents for determining the potency of anticonvulsants acting through GABAergic mechanisms

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7 January 2021

The immediate consequences of middle cerebral artery occlusion on GABA synthesis in mouse cortex and cerebellum

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A behavioural and neurochemical study in rats of the pharmacology of loreclezole, a novel allosteric modulator of the GABAA receptor

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An investigation of the possible interaction of clomethiazole with glutamate and ion channel sites as an explanation of its neuroprotective activity.

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GABA potentiation: a logical pharmacological approach for the treatment of acute ischaemic stroke

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The metabolism of clomethiazole in gerbils and the neuroprotective and sedative activity of the metabolites

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High affinity specific [3H] (+)PN 200-110 binding to dihydropyridine receptors associated with calcium channels in rat cerebral cortex and heart

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Chlormethiazole: neurochemical actions at the gamma-aminobutyric acid receptor complex

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Characterization of quisqualate recognition sites in rat brain tissue using DL-[3H]alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) and a filtration assay.

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7 January 2021

On the regulation of ischaemia-induced glutamate efflux from rat cortex by GABA; in vitro studies with GABA, clomethiazole and pentobarbitone.

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7 January 2021

Neuroprotective efficacy of AR-A008055, a clomethiazole analogue, in a global model of acute ischaemic stroke and its effect on ischaemia-induced glutamate and GABA efflux in vitro.

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7 January 2021

Characterization of tiagabine (NO-328), a new potent and selective GABA uptake inhibitor

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The binding of [3H]thienyl cyclohexylpiperidine ([3H]TCP) to the NMDA-phencyclidine receptor complex

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[35S]-t-butylbicyclophosphorothionate binding sites are constituents of the gamma-aminobutyric acid benzodiazepine receptor complex.

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7 January 2021

Clomethiazole acute stroke study (CLASS): results of a randomized, controlled trial of clomethiazole versus placebo in 1360 acute stroke patients.

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7 January 2021

An open study of clomethiazole in patients with acute cerebral infarction

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Calcium antagonists: their role in neuroprotection.

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Sodium and potassium channel modulators: their role in neuroprotection.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S0028-3908(01)00053-3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11489453%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11489453%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

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