(Q35021849)

5 August 2017

title

Disulfide scrambling in superoxide dismutase 1 reduces its cytotoxic effect in cultured cells and promotes protein aggregation (English)

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5 August 2017

1 reference

Lina Leinartaitė

1

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5 August 2017

Ann-Sofi Johansson

series ordinal

2

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5 August 2017

language of work or name

English

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publication date

15 October 2013

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5 August 2017

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5 August 2017

volume

8

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5 August 2017

issue

10

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5 August 2017

page(s)

e78060

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Creative Commons Attribution 4.0 International

5 August 2017

copyright license

start time

15 October 2013

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April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Fibrillation precursor of superoxide dismutase 1 revealed by gradual tuning of the protein-folding equilibrium

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Cytotoxicity of superoxide dismutase 1 in cultured cells is linked to Zn2+ chelation

8 July 2018

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Disulfide-reduced ALS variants of Cu, Zn superoxide dismutase exhibit increased populations of unfolded species

8 July 2018

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Role of mutant SOD1 disulfide oxidation and aggregation in the pathogenesis of familial ALS

8 July 2018

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Structural and dynamic aspects related to oligomerization of apo SOD1 and its mutants

8 July 2018

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Initiation and elongation in fibrillation of ALS-linked superoxide dismutase

8 July 2018

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Different regulation of wild-type and mutant Cu,Zn superoxide dismutase localization in mammalian mitochondria

8 July 2018

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Complete loss of post-translational modifications triggers fibrillar aggregation of SOD1 in the familial form of amyotrophic lateral sclerosis

8 July 2018

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A limited role for disulfide cross-linking in the aggregation of mutant SOD1 linked to familial amyotrophic lateral sclerosis.

8 July 2018

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Cysteine 111 affects aggregation and cytotoxicity of mutant Cu,Zn-superoxide dismutase associated with familial amyotrophic lateral sclerosis

8 July 2018

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Soluble misfolded subfractions of mutant superoxide dismutase-1s are enriched in spinal cords throughout life in murine ALS models

8 July 2018

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Disulfide bond mediates aggregation, toxicity, and ubiquitylation of familial amyotrophic lateral sclerosis-linked mutant SOD1.

8 July 2018

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Metal-free superoxide dismutase forms soluble oligomers under physiological conditions: a possible general mechanism for familial ALS

8 July 2018

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Disulfide cross-linked protein represents a significant fraction of ALS-associated Cu, Zn-superoxide dismutase aggregates in spinal cords of model mice

8 July 2018

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Mapping superoxide dismutase 1 domains of non-native interaction: roles of intra- and intermolecular disulfide bonding in aggregation

8 July 2018

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Folding of human superoxide dismutase: disulfide reduction prevents dimerization and produces marginally stable monomers

8 July 2018

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ALS mutants of human superoxide dismutase form fibrous aggregates via framework destabilization

8 July 2018

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Common denominator of Cu/Zn superoxide dismutase mutants associated with amyotrophic lateral sclerosis: decreased stability of the apo state

8 July 2018

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Heterodimeric structure of superoxide dismutase in complex with its metallochaperone

8 July 2018

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8 July 2018

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Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury

8 July 2018

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8 July 2018

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Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity

8 July 2018

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Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cells

8 July 2018

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Multiple neurotransmitter synthesis by human neuroblastoma cell lines and clones

8 July 2018

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Oxidative stress in cell culture: an under-appreciated problem?

8 July 2018

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Structure and assembly-disassembly properties of wild-type transthyretin amyloid protofibrils observed with atomic force microscopy.

21 January 2018

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Huntingtin spheroids and protofibrils as precursors in polyglutamine fibrilization

21 January 2018

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Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease.

21 January 2018

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Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate.

21 January 2018

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Disulfide scrambling describes the oligomer formation of superoxide dismutase (SOD1) proteins in the familial form of amyotrophic lateral sclerosis.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0078060

Proteasomal degradation of mutant superoxide dismutases linked to amyotrophic lateral sclerosis

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0078060

Amyotrophic lateral sclerosis mutations have the greatest destabilizing effect on the apo- and reduced form of SOD1, leading to unfolding and oxidative aggregation.

21 January 2018

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Calorimetric analysis of thermodynamic stability and aggregation for apo and holo amyotrophic lateral sclerosis-associated Gly-93 mutants of superoxide dismutase

21 January 2018

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Factors controlling the uptake of yeast copper/zinc superoxide dismutase into mitochondria.

21 January 2018

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Understanding conserved amino acids in proteins

21 January 2018

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A novel ALS SOD1 C6S mutation with implications for aggregation related toxicity and genetic counseling

21 January 2018

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Marked intrafamilial phenotypic variation in a family with SOD1 C111Y mutation

21 January 2018

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A novel mutation (Cys6Gly) in the Cu/Zn superoxide dismutase gene associated with rapidly progressive familial amyotrophic lateral sclerosis

9 December 2018

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12 December 2020

A spectroscopic characterization of a monomeric analog of copper, zinc superoxide dismutase

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12 December 2020

Sporadic amyotrophic lateral sclerosis with dementia and Cu/Zn superoxide dismutase-positive Lewy body-like inclusions

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12 December 2020

A novel two-base mutation in the Cu/Zn superoxide dismutase gene associated with familial amyotrophic lateral sclerosis in Japan

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12 December 2020

Disulphide-reduced superoxide dismutase-1 in CNS of transgenic amyotrophic lateral sclerosis models

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12 December 2020

Inclusions of amyotrophic lateral sclerosis-linked superoxide dismutase in ventral horns, liver, and kidney

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0078060

Identifiers

DOI

1 reference

5 August 2017

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5 August 2017

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